CL2004002035A1 - Anticuerpo monoclonal humano contra el receptor del factor de crecimiento de tipo insulino 1 (igf-1r), acido nucleico que lo codifica, vector, celula huesped, metodo para su produccion, composiciones farmaceuticas que lo contienen y usos de los mismo - Google Patents
Anticuerpo monoclonal humano contra el receptor del factor de crecimiento de tipo insulino 1 (igf-1r), acido nucleico que lo codifica, vector, celula huesped, metodo para su produccion, composiciones farmaceuticas que lo contienen y usos de los mismoInfo
- Publication number
- CL2004002035A1 CL2004002035A1 CL200402035A CL2004002035A CL2004002035A1 CL 2004002035 A1 CL2004002035 A1 CL 2004002035A1 CL 200402035 A CL200402035 A CL 200402035A CL 2004002035 A CL2004002035 A CL 2004002035A CL 2004002035 A1 CL2004002035 A1 CL 2004002035A1
- Authority
- CL
- Chile
- Prior art keywords
- igf
- receptor
- vector
- nucleic acid
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49520003P | 2003-08-13 | 2003-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004002035A1 true CL2004002035A1 (es) | 2005-06-03 |
Family
ID=34193291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200402035A CL2004002035A1 (es) | 2003-08-13 | 2004-08-10 | Anticuerpo monoclonal humano contra el receptor del factor de crecimiento de tipo insulino 1 (igf-1r), acido nucleico que lo codifica, vector, celula huesped, metodo para su produccion, composiciones farmaceuticas que lo contienen y usos de los mismo |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US7371378B2 (es) |
| EP (1) | EP1656391B1 (es) |
| JP (1) | JP4638870B2 (es) |
| KR (1) | KR100825156B1 (es) |
| CN (1) | CN1835975B (es) |
| AP (1) | AP2006003510A0 (es) |
| AR (1) | AR045247A1 (es) |
| AT (1) | ATE484525T1 (es) |
| AU (1) | AU2004265152A1 (es) |
| BR (1) | BRPI0413466A (es) |
| CA (1) | CA2535071A1 (es) |
| CL (1) | CL2004002035A1 (es) |
| CR (1) | CR8233A (es) |
| DE (1) | DE602004029581D1 (es) |
| DK (1) | DK1656391T3 (es) |
| EA (1) | EA200600234A1 (es) |
| EC (1) | ECSP066359A (es) |
| ES (1) | ES2351395T3 (es) |
| GT (1) | GT200400158A (es) |
| IL (1) | IL173273A (es) |
| IS (1) | IS8266A (es) |
| MA (1) | MA27988A1 (es) |
| MX (1) | MXPA06001634A (es) |
| NL (1) | NL1026829C2 (es) |
| NO (1) | NO20060542L (es) |
| OA (1) | OA13234A (es) |
| PA (1) | PA8608801A1 (es) |
| PE (1) | PE20050339A1 (es) |
| PL (1) | PL1656391T3 (es) |
| PT (1) | PT1656391E (es) |
| RS (1) | RS20060099A (es) |
| TN (1) | TNSN06050A1 (es) |
| TW (1) | TWI294915B (es) |
| UA (1) | UA85058C2 (es) |
| UY (1) | UY28464A1 (es) |
| WO (1) | WO2005016967A2 (es) |
| ZA (1) | ZA200601231B (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1399483E (pt) | 2001-01-05 | 2010-07-20 | Pfizer | Anticorpos contra o receptor do factor i de crescimento tipo insulina |
| US7217796B2 (en) | 2002-05-24 | 2007-05-15 | Schering Corporation | Neutralizing human anti-IGFR antibody |
| ES2527871T3 (es) * | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| PL1656391T3 (pl) * | 2003-08-13 | 2011-03-31 | Pfizer Prod Inc | Zmodyfikowane ludzkie przeciwciała IGF-1R |
| EP1694850B1 (en) | 2003-11-12 | 2011-06-29 | Schering Corporation | Plasmid system for multigene expression |
| PE20050928A1 (es) | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
| EP2322217A3 (en) * | 2004-07-16 | 2011-09-28 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
| FR2873699B1 (fr) * | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| ES2356830T3 (es) | 2004-12-03 | 2011-04-13 | Schering Corporation | Biomarcadores para preselección de pacientes para terapia de anti-igf-1r. |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| GB0500417D0 (en) * | 2005-01-10 | 2005-02-16 | Cambridge Antibody Tech | Method of mutagenesis |
| US20060233810A1 (en) * | 2005-04-15 | 2006-10-19 | Yaolin Wang | Methods and compositions for treating or preventing cancer |
| CA2611149A1 (en) * | 2005-06-15 | 2006-12-28 | Schering Corporation | Anti-igf1r antibody formulations |
| CA2678008C (en) * | 2005-06-17 | 2013-07-30 | Imclone Systems Incorporated | Methods of treating a secondary bone tumor with anti-pdgfralpha antibodies |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| CN101484587B (zh) * | 2006-02-03 | 2014-02-12 | 英克隆有限责任公司 | Igf-ir拮抗剂作为辅药用于前列腺癌的治疗 |
| AU2007229554A1 (en) * | 2006-03-28 | 2007-10-04 | F. Hoffmann-La Roche Ag | Anti-IGF-1R human monoclonal antibody formulation |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| KR20090023423A (ko) * | 2006-06-02 | 2009-03-04 | 화이자 프로덕츠 인코포레이티드 | 순환 종양 세포 분석 |
| TW200833711A (en) * | 2006-12-22 | 2008-08-16 | Genentech Inc | Antibodies to insulin-like growth factor receptor |
| GB0702888D0 (en) * | 2007-02-14 | 2007-03-28 | Glaxo Group Ltd | Novel Antibodies |
| EP2129397B1 (en) * | 2007-03-02 | 2018-10-31 | Amgen, Inc. | Methods and compositions for treating tumor diseases |
| AU2012203443B2 (en) * | 2007-03-02 | 2014-03-06 | Amgen Inc. | Methods and compositions for treating tumor diseases |
| US20100260766A1 (en) * | 2007-03-22 | 2010-10-14 | Arvind Srivastava | Stable antibody formulations |
| WO2008144345A2 (en) | 2007-05-17 | 2008-11-27 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
| US20100261216A1 (en) | 2007-12-21 | 2010-10-14 | Bianca Eser | Stability testing of antibodies |
| EP2259797A2 (en) * | 2008-03-25 | 2010-12-15 | Schering Corporation | Methods for treating or preventing colorectal cancer |
| MX2010012064A (es) * | 2008-05-05 | 2010-12-06 | Schering Corp | Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer. |
| AU2009313389A1 (en) * | 2008-11-06 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Engineered antibodies with reduced immunogenicity and methods of making |
| US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| EP2236139A1 (en) | 2009-03-31 | 2010-10-06 | F. Hoffmann-La Roche AG | Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor |
| US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
| TWI513465B (zh) | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以ｄｌｌ４拮抗劑與化學治療劑治療癌症之方法 |
| ES2622366T3 (es) | 2009-10-26 | 2017-07-06 | F. Hoffmann-La Roche Ag | Procedimiento para la producción de una inmunoglobulina glucosilada |
| US20120220594A1 (en) | 2009-10-30 | 2012-08-30 | Bristol-Meyers Squibb Company | Methods for treating cancer in patients having igf-1r inhibitor resistance |
| AU2014262201B2 (en) * | 2009-12-23 | 2016-09-15 | Novartis Ag | Method for decreasing immunogenicity |
| CA2777527C (en) * | 2009-12-23 | 2020-06-23 | Esbatech, An Alcon Biomedical Research Unit Llc | Method for decreasing immunogenicity |
| WO2011101328A2 (en) | 2010-02-18 | 2011-08-25 | Roche Glycart Ag | Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor |
| WO2011161119A1 (en) | 2010-06-22 | 2011-12-29 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
| EP2593142B8 (en) | 2010-07-12 | 2018-12-26 | Pfizer Healthcare Ireland | Multifunctional antibody conjugates |
| AU2012212075A1 (en) | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
| EP2699598B1 (en) | 2011-04-19 | 2019-03-06 | Pfizer Inc | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| US20140309229A1 (en) | 2011-10-13 | 2014-10-16 | Bristol-Myers Squibb Company | Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors |
| ES2700398T3 (es) * | 2012-01-09 | 2019-02-15 | Pfizer Healthcare Ireland | Anticuerpos mutantes y conjugación de los mismos |
| EP2631653A1 (en) | 2012-02-24 | 2013-08-28 | Charité - Universitätsmedizin Berlin | Identification of modulators of binding properties of antibodies reactive with a member of the insulin receptor family |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| JP2015535005A (ja) * | 2012-11-06 | 2015-12-07 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）ＰｓｌおよびＰｃｒＶ結合分子を用いた併用治療 |
| JP2016528167A (ja) | 2013-04-29 | 2016-09-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ヒトＦｃＲｎ結合改変抗体及び使用方法 |
| CN103319598B (zh) * | 2013-05-13 | 2014-10-22 | 杭州德同生物技术有限公司 | 抗胰岛素样生长因子-1受体抗体及其编码基因和应用 |
| BR112016014969A2 (pt) | 2014-01-15 | 2018-01-23 | Hoffmann La Roche | polipeptídeo, formulação farmacêutica e uso de um polipeptídeo |
| CN110997720A (zh) * | 2017-07-27 | 2020-04-10 | Iteos治疗公司 | 抗tigit抗体 |
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| CN100410275C (zh) | 2002-01-18 | 2008-08-13 | 皮埃尔法布雷医药公司 | 新的抗igf-ir抗体及其应用 |
| AU2003231554A1 (en) | 2002-04-30 | 2003-11-17 | Kyowa Hakko Kogyo Co., Ltd. | Antibody to human insulin-like growth factor |
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| JP2006517581A (ja) | 2003-02-13 | 2006-07-27 | ファイザー・プロダクツ・インク | 抗インスリン様増殖因子ｉ受容体抗体の使用 |
| MXPA05009837A (es) | 2003-03-14 | 2005-12-05 | Pharmacia Corp | Anticuerpos para el receptor del factor de crecimiento tipo insulina-i, para el tratamiento de canceres. |
| ES2383014T3 (es) | 2003-04-02 | 2012-06-15 | F. Hoffmann-La Roche Ag | Anticuerpos contra el factor I de crecimiento similar a insulina y usos de los mismos |
| PL1656391T3 (pl) * | 2003-08-13 | 2011-03-31 | Pfizer Prod Inc | Zmodyfikowane ludzkie przeciwciała IGF-1R |
-
2004
- 2004-08-03 PL PL04744197T patent/PL1656391T3/pl unknown
- 2004-08-03 ES ES04744197T patent/ES2351395T3/es active Active
- 2004-08-03 UA UAA200601349A patent/UA85058C2/ru unknown
- 2004-08-03 AT AT04744197T patent/ATE484525T1/de active
- 2004-08-03 AU AU2004265152A patent/AU2004265152A1/en not_active Abandoned
- 2004-08-03 OA OA1200600046A patent/OA13234A/en unknown
- 2004-08-03 BR BRPI0413466-4A patent/BRPI0413466A/pt not_active IP Right Cessation
- 2004-08-03 JP JP2006523070A patent/JP4638870B2/ja not_active Expired - Fee Related
- 2004-08-03 KR KR1020067002957A patent/KR100825156B1/ko not_active IP Right Cessation
- 2004-08-03 AP AP2006003510A patent/AP2006003510A0/xx unknown
- 2004-08-03 PT PT04744197T patent/PT1656391E/pt unknown
- 2004-08-03 CA CA002535071A patent/CA2535071A1/en not_active Abandoned
- 2004-08-03 MX MXPA06001634A patent/MXPA06001634A/es unknown
- 2004-08-03 WO PCT/IB2004/002555 patent/WO2005016967A2/en active Application Filing
- 2004-08-03 EA EA200600234A patent/EA200600234A1/ru unknown
- 2004-08-03 EP EP04744197A patent/EP1656391B1/en active Active
- 2004-08-03 RS YUP-2006/0099A patent/RS20060099A/sr unknown
- 2004-08-03 DK DK04744197.7T patent/DK1656391T3/da active
- 2004-08-03 CN CN2004800230991A patent/CN1835975B/zh not_active Expired - Fee Related
- 2004-08-03 DE DE602004029581T patent/DE602004029581D1/de active Active
- 2004-08-09 PE PE2004000773A patent/PE20050339A1/es not_active Application Discontinuation
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- 2004-08-11 AR ARP040102870A patent/AR045247A1/es active IP Right Grant
- 2004-08-12 TW TW093124269A patent/TWI294915B/zh not_active IP Right Cessation
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- 2004-08-12 NL NL1026829A patent/NL1026829C2/nl not_active IP Right Cessation
- 2004-08-12 US US10/917,073 patent/US7371378B2/en not_active Expired - Fee Related
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2006
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2008
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