CH623038A5 - Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate - Google Patents

Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate Download PDF

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Publication number
CH623038A5
CH623038A5 CH1381976A CH1381976A CH623038A5 CH 623038 A5 CH623038 A5 CH 623038A5 CH 1381976 A CH1381976 A CH 1381976A CH 1381976 A CH1381976 A CH 1381976A CH 623038 A5 CH623038 A5 CH 623038A5
Authority
CH
Switzerland
Prior art keywords
formula
dimethyl
methoxycarbonyl
nitrophenyl
dihydropyridine
Prior art date
Application number
CH1381976A
Other languages
German (de)
English (en)
Inventor
Egbert Dr Wehinger
Friedrich Dr Bossert
Arend Dr Heise
Stanislav Dr Kazda
Kurt Dr Stoepel
Wulf Dr Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CH623038A5 publication Critical patent/CH623038A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1381976A 1975-11-05 1976-11-02 Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate CH623038A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2549568A DE2549568C3 (de) 1975-11-05 1975-11-05 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CH623038A5 true CH623038A5 (en) 1981-05-15

Family

ID=5960951

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1381976A CH623038A5 (en) 1975-11-05 1976-11-02 Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate
CH567880A CH622779A5 (en) 1975-11-05 1980-07-23 Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH567880A CH622779A5 (en) 1975-11-05 1980-07-23 Process for the preparation of novel isobutyl 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine- 5-carboxylate

Country Status (27)

Country Link
JP (1) JPS5259161A (fr)
AT (1) AT352129B (fr)
AU (1) AU498964B2 (fr)
BE (1) BE847968A (fr)
BG (6) BG24805A3 (fr)
CA (1) CA1085406A (fr)
CH (2) CH623038A5 (fr)
CS (1) CS200499B2 (fr)
DE (1) DE2549568C3 (fr)
DK (1) DK146762C (fr)
ES (2) ES452986A1 (fr)
FI (1) FI60704C (fr)
FR (1) FR2330395A1 (fr)
GB (1) GB1516793A (fr)
GR (1) GR61241B (fr)
HK (1) HK12681A (fr)
IE (1) IE43984B1 (fr)
IL (1) IL50817A (fr)
LU (2) LU76133A1 (fr)
NL (2) NL175915C (fr)
NO (1) NO145574C (fr)
NZ (1) NZ182502A (fr)
PL (2) PL105940B1 (fr)
PT (1) PT65797B (fr)
RO (1) RO70295A (fr)
SE (1) SE423542B (fr)
ZA (1) ZA766622B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
JPS5982192U (ja) * 1982-11-27 1984-06-02 エムケ−精工株式会社 扉
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312216A1 (de) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CH622779A5 (en) 1981-04-30
DE2549568B2 (de) 1980-08-21
BG25079A3 (en) 1978-07-12
ZA766622B (en) 1977-10-26
AU1935876A (en) 1978-05-11
CA1085406A (fr) 1980-09-09
NO763608L (fr) 1977-05-06
NL930035I2 (nl) 1993-10-01
PT65797B (de) 1978-05-12
LU76133A1 (fr) 1977-06-02
LU88275I2 (fr) 1994-02-03
NO145574B (no) 1982-01-11
ES452986A1 (es) 1977-12-16
CS200499B2 (en) 1980-09-15
FI60704C (fi) 1982-03-10
AT352129B (de) 1979-09-10
NL175915C (nl) 1985-01-16
IL50817A0 (en) 1977-01-31
BE847968A (fr) 1977-05-04
JPS5647185B2 (fr) 1981-11-07
PT65797A (de) 1976-12-01
HK12681A (en) 1981-04-10
RO70295A (fr) 1981-08-17
BG24805A3 (en) 1978-05-12
ES463166A1 (es) 1978-07-16
FI60704B (fi) 1981-11-30
SE423542B (sv) 1982-05-10
SE7612308L (sv) 1977-05-06
BG24804A3 (en) 1978-05-12
IL50817A (en) 1979-07-25
BG24803A3 (en) 1978-05-12
BG24668A3 (en) 1978-04-12
AU498964B2 (en) 1979-03-29
ATA814276A (de) 1979-02-15
FR2330395A1 (fr) 1977-06-03
PL106084B1 (pl) 1979-11-30
FR2330395B1 (fr) 1978-12-22
IE43984L (en) 1977-05-05
DK146762B (da) 1983-12-27
JPS5259161A (en) 1977-05-16
PL105940B1 (pl) 1979-11-30
DE2549568C3 (de) 1981-10-29
BG25078A3 (en) 1978-07-12
DE2549568A1 (de) 1977-05-18
FI763160A (fr) 1977-05-06
GR61241B (en) 1978-10-12
DK146762C (da) 1984-06-12
NL7612198A (nl) 1977-05-09
NL930035I1 (nl) 1993-08-02
IE43984B1 (en) 1981-07-15
NO145574C (no) 1982-04-21
NZ182502A (en) 1978-07-28
GB1516793A (en) 1978-07-05
DK498476A (da) 1977-05-06

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