CH619462A5 - Process for the preparation of novel piperazinylpyrazines - Google Patents

Process for the preparation of novel piperazinylpyrazines Download PDF

Info

Publication number
CH619462A5
CH619462A5 CH492676A CH492676A CH619462A5 CH 619462 A5 CH619462 A5 CH 619462A5 CH 492676 A CH492676 A CH 492676A CH 492676 A CH492676 A CH 492676A CH 619462 A5 CH619462 A5 CH 619462A5
Authority
CH
Switzerland
Prior art keywords
group
carbon atoms
piperazinyl
acid
pyrazine
Prior art date
Application number
CH492676A
Other languages
German (de)
English (en)
Inventor
Walfred Spencer Saari
William Carl Lumma Jr
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH619462A5 publication Critical patent/CH619462A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH492676A 1975-04-21 1976-04-20 Process for the preparation of novel piperazinylpyrazines CH619462A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (1)

Publication Number Publication Date
CH619462A5 true CH619462A5 (en) 1980-09-30

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
CH492676A CH619462A5 (en) 1975-04-21 1976-04-20 Process for the preparation of novel piperazinylpyrazines

Country Status (36)

Country Link
JP (1) JPS51136688A (nl)
AR (1) AR210349A1 (nl)
AT (1) AT353795B (nl)
AU (1) AU496854B2 (nl)
BE (1) BE840904A (nl)
BG (1) BG34185A3 (nl)
CA (1) CA1059128A (nl)
CH (1) CH619462A5 (nl)
CS (1) CS195726B2 (nl)
CY (1) CY1090A (nl)
DD (1) DD124599A5 (nl)
DE (1) DE2617205C3 (nl)
DK (1) DK143899C (nl)
EG (1) EG12387A (nl)
ES (4) ES447150A1 (nl)
FI (1) FI62666C (nl)
FR (1) FR2308367A1 (nl)
GB (1) GB1492528A (nl)
GR (1) GR59900B (nl)
HK (1) HK60380A (nl)
HU (1) HU172684B (nl)
IE (1) IE42979B1 (nl)
IL (1) IL49391A (nl)
KE (1) KE3088A (nl)
LU (1) LU74795A1 (nl)
MY (1) MY8100225A (nl)
NL (1) NL167692C (nl)
NO (1) NO146599C (nl)
PH (1) PH12274A (nl)
PL (1) PL99664B1 (nl)
PT (1) PT65027B (nl)
RO (1) RO73278A (nl)
SE (1) SE421695B (nl)
SU (1) SU638260A3 (nl)
YU (1) YU100676A (nl)
ZA (1) ZA762320B (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0120465A1 (de) * 1983-03-25 1984-10-03 Degussa Aktiengesellschaft Neue N-Phenyl-N'-Cycloalkylalkanoyl-piperazine und Verfahren zu deren Herstellung

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
DK1027336T3 (da) * 1997-10-27 2005-01-24 Neurosearch As Heteroaryldiazacycloalkaner, deres fremstilling og anvendelse
NZ514021A (en) 1999-04-26 2001-09-28 Neurosearch As Heteroaryl diazacycloalkanes, their preparation and use
BR0108363A (pt) * 2000-02-16 2004-02-10 Neurogen Corp Composto, métodos para modular função de receptor de crf e acoplado a proteìna g, para tratar um distúrbio ou doença do snc, para localizar receptores de crf em amostras de seção de tecidos, para inibir a ligação de crf a um receptor de crf¹ e para alterar a atividade de transdução de sinal de um receptor de crf¹ e composição farmacêutica
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
DE60311822T2 (de) * 2002-07-19 2007-12-06 Biovitrum Ab Neue piperazinyl-pyrazinon-derivate zur behandlung von 5-ht2a rezeptor-bedingten erkrankungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0120465A1 (de) * 1983-03-25 1984-10-03 Degussa Aktiengesellschaft Neue N-Phenyl-N'-Cycloalkylalkanoyl-piperazine und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
HK60380A (en) 1980-11-07
DE2617205A1 (de) 1976-10-28
NL167692C (nl) 1982-01-18
EG12387A (en) 1978-12-31
ATA288376A (de) 1979-05-15
KE3088A (en) 1980-11-07
ES459407A1 (es) 1978-08-16
NO146599B (no) 1982-07-26
IL49391A (en) 1979-09-30
NO761207L (nl) 1976-10-22
BG34185A3 (en) 1983-07-15
AU1296676A (en) 1977-10-20
JPS51136688A (en) 1976-11-26
DE2617205B2 (de) 1980-05-08
FI62666C (fi) 1983-02-10
NL167692B (nl) 1981-08-17
SE421695B (sv) 1982-01-25
PT65027B (en) 1978-04-03
AT353795B (de) 1979-12-10
LU74795A1 (nl) 1977-02-07
ES459406A1 (es) 1978-08-16
DK143899C (da) 1982-04-13
AU496854B2 (en) 1978-11-02
ZA762320B (en) 1977-11-30
GR59900B (en) 1978-03-16
DK143899B (da) 1981-10-26
BE840904A (fr) 1976-08-16
IE42979L (en) 1976-10-21
CY1090A (en) 1980-12-27
FI760978A (nl) 1976-10-22
MY8100225A (en) 1981-12-31
DK164476A (da) 1976-10-22
JPS5522475B2 (nl) 1980-06-17
ES447150A1 (es) 1977-09-16
DD124599A5 (nl) 1977-03-02
GB1492528A (en) 1977-11-23
PT65027A (en) 1976-05-01
CA1059128A (en) 1979-07-24
RO73278A (ro) 1982-09-09
AR210349A1 (es) 1977-07-29
YU100676A (en) 1982-08-31
SU638260A3 (ru) 1978-12-15
PH12274A (en) 1978-12-12
PL99664B1 (pl) 1978-07-31
NO146599C (no) 1982-11-03
CS195726B2 (en) 1980-02-29
FR2308367A1 (fr) 1976-11-19
FR2308367B1 (nl) 1979-09-21
IE42979B1 (en) 1980-11-19
NL7603800A (nl) 1976-10-25
HU172684B (hu) 1978-11-28
IL49391A0 (en) 1976-06-30
DE2617205C3 (de) 1981-01-29
FI62666B (fi) 1982-10-29
SE7604093L (sv) 1976-10-22
ES459405A1 (es) 1978-08-16

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Date Code Title Description
PL Patent ceased