IL49391A - 6-chloro-2-(1-piperazinyl)pyrazine and acid addition salts, their preparation and pharmaceutical compositions containing them - Google Patents
6-chloro-2-(1-piperazinyl)pyrazine and acid addition salts, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL49391A IL49391A IL49391A IL4939176A IL49391A IL 49391 A IL49391 A IL 49391A IL 49391 A IL49391 A IL 49391A IL 4939176 A IL4939176 A IL 4939176A IL 49391 A IL49391 A IL 49391A
- Authority
- IL
- Israel
- Prior art keywords
- pyrazine
- piperazinyl
- chloro
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57005275A | 1975-04-21 | 1975-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL49391A0 IL49391A0 (en) | 1976-06-30 |
| IL49391A true IL49391A (en) | 1979-09-30 |
Family
ID=24277994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL49391A IL49391A (en) | 1975-04-21 | 1976-04-12 | 6-chloro-2-(1-piperazinyl)pyrazine and acid addition salts, their preparation and pharmaceutical compositions containing them |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS51136688A (en) |
| AR (1) | AR210349A1 (en) |
| AT (1) | AT353795B (en) |
| AU (1) | AU496854B2 (en) |
| BE (1) | BE840904A (en) |
| BG (1) | BG34185A3 (en) |
| CA (1) | CA1059128A (en) |
| CH (1) | CH619462A5 (en) |
| CS (1) | CS195726B2 (en) |
| CY (1) | CY1090A (en) |
| DD (1) | DD124599A5 (en) |
| DE (1) | DE2617205C3 (en) |
| DK (1) | DK143899C (en) |
| EG (1) | EG12387A (en) |
| ES (4) | ES447150A1 (en) |
| FI (1) | FI62666C (en) |
| FR (1) | FR2308367A1 (en) |
| GB (1) | GB1492528A (en) |
| GR (1) | GR59900B (en) |
| HK (1) | HK60380A (en) |
| HU (1) | HU172684B (en) |
| IE (1) | IE42979B1 (en) |
| IL (1) | IL49391A (en) |
| KE (1) | KE3088A (en) |
| LU (1) | LU74795A1 (en) |
| MY (1) | MY8100225A (en) |
| NL (1) | NL167692C (en) |
| NO (1) | NO146599C (en) |
| PH (1) | PH12274A (en) |
| PL (1) | PL99664B1 (en) |
| PT (1) | PT65027B (en) |
| RO (1) | RO73278A (en) |
| SE (1) | SE421695B (en) |
| SU (1) | SU638260A3 (en) |
| YU (1) | YU100676A (en) |
| ZA (1) | ZA762320B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| US4252816A (en) * | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| EP0580465A1 (en) * | 1992-06-25 | 1994-01-26 | Sanofi | New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives |
| DE69842058D1 (en) * | 1997-10-27 | 2011-01-27 | Neurosearch As | Heteroaryl Diazacycloalkanes as cholinergic ligands for nicotine acetylcholine receptors |
| JP2002543070A (en) | 1999-04-26 | 2002-12-17 | ニューロサーチ、アクティーゼルスカブ | Heteroaryldiazacycloalkanes, their production and use |
| KR20030031886A (en) * | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | Substituted arylpyrazines |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| SE0202287D0 (en) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
| DK1534391T3 (en) | 2002-07-19 | 2007-06-11 | Biovitrum Ab | New piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
-
1976
- 1976-04-07 SE SE7604093A patent/SE421695B/en not_active IP Right Cessation
- 1976-04-07 DK DK164476A patent/DK143899C/en not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/en active
- 1976-04-08 NO NO761207A patent/NO146599C/en unknown
- 1976-04-09 FI FI760978A patent/FI62666C/en not_active IP Right Cessation
- 1976-04-09 NL NL7603800A patent/NL167692C/en not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 GR GR50538A patent/GR59900B/en unknown
- 1976-04-14 FR FR7610958A patent/FR2308367A1/en active Granted
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-15 CY CY1090A patent/CY1090A/en unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/en unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/en active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/en not_active Expired
- 1976-04-20 ZA ZA762320A patent/ZA762320B/en unknown
- 1976-04-20 BG BG7632968A patent/BG34185A3/en unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/en unknown
- 1976-04-20 BE BE166282A patent/BE840904A/en not_active IP Right Cessation
- 1976-04-20 CH CH492676A patent/CH619462A5/en not_active IP Right Cessation
- 1976-04-20 AR AR262930A patent/AR210349A1/en active
- 1976-04-20 RO RO7685688A patent/RO73278A/en unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/en active
- 1976-04-20 DE DE2617205A patent/DE2617205C3/en not_active Expired
- 1976-04-20 AT AT288376A patent/AT353795B/en not_active IP Right Cessation
- 1976-04-20 YU YU01006/76A patent/YU100676A/en unknown
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/en unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
-
1977
- 1977-06-01 ES ES459405A patent/ES459405A1/en not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/en not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/en not_active Expired
-
1980
- 1980-10-02 KE KE3088A patent/KE3088A/en unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/en unknown
-
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/en unknown
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