ES459407A1 - Pyrazinyl piperazine derivatives - Google Patents

Pyrazinyl piperazine derivatives

Info

Publication number
ES459407A1
ES459407A1 ES459407A ES459407A ES459407A1 ES 459407 A1 ES459407 A1 ES 459407A1 ES 459407 A ES459407 A ES 459407A ES 459407 A ES459407 A ES 459407A ES 459407 A1 ES459407 A1 ES 459407A1
Authority
ES
Spain
Prior art keywords
pyrazinyl
compounds
piperazine derivatives
prepared
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459407A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES459407A1 publication Critical patent/ES459407A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Abstract

Novel piperazinylpyrazines of the formula < IMAGE > in which the substituents are defined in Claim 1, and their N-oxides are prepared. These compounds are obtained by reacting an appropriate pyrazine or its N-oxide, which contains an easily removable group in the 2-position, which is defined in Claim 1, with an appropriate piperazine. The compounds III are also prepared as acid addition salts. The compounds obtained can be used in pharmaceutical compositions having anorexic action.
ES459407A 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives Expired ES459407A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (1)

Publication Number Publication Date
ES459407A1 true ES459407A1 (en) 1978-08-16

Family

ID=24277994

Family Applications (4)

Application Number Title Priority Date Filing Date
ES447150A Expired ES447150A1 (en) 1975-04-21 1976-04-19 Pyrazinyl piperazine derivatives
ES459407A Expired ES459407A1 (en) 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives
ES459405A Expired ES459405A1 (en) 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives
ES459406A Expired ES459406A1 (en) 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES447150A Expired ES447150A1 (en) 1975-04-21 1976-04-19 Pyrazinyl piperazine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES459405A Expired ES459405A1 (en) 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives
ES459406A Expired ES459406A1 (en) 1975-04-21 1977-06-01 Pyrazinyl piperazine derivatives

Country Status (36)

Country Link
JP (1) JPS51136688A (en)
AR (1) AR210349A1 (en)
AT (1) AT353795B (en)
AU (1) AU496854B2 (en)
BE (1) BE840904A (en)
BG (1) BG34185A3 (en)
CA (1) CA1059128A (en)
CH (1) CH619462A5 (en)
CS (1) CS195726B2 (en)
CY (1) CY1090A (en)
DD (1) DD124599A5 (en)
DE (1) DE2617205C3 (en)
DK (1) DK143899C (en)
EG (1) EG12387A (en)
ES (4) ES447150A1 (en)
FI (1) FI62666C (en)
FR (1) FR2308367A1 (en)
GB (1) GB1492528A (en)
GR (1) GR59900B (en)
HK (1) HK60380A (en)
HU (1) HU172684B (en)
IE (1) IE42979B1 (en)
IL (1) IL49391A (en)
KE (1) KE3088A (en)
LU (1) LU74795A1 (en)
MY (1) MY8100225A (en)
NL (1) NL167692C (en)
NO (1) NO146599C (en)
PH (1) PH12274A (en)
PL (1) PL99664B1 (en)
PT (1) PT65027B (en)
RO (1) RO73278A (en)
SE (1) SE421695B (en)
SU (1) SU638260A3 (en)
YU (1) YU100676A (en)
ZA (1) ZA762320B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (en) * 1992-06-25 1994-01-26 Sanofi New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives
DK1027336T3 (en) * 1997-10-27 2005-01-24 Neurosearch As Heter Garyldiazacycloalkanes, their preparation and use
ATE245153T1 (en) 1999-04-26 2003-08-15 Neurosearch As HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE
AP2002002620A0 (en) * 2000-02-16 2002-09-30 Neurogen Corp Substituted arylpyrazines
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (en) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
NZ537629A (en) 2002-07-19 2007-05-31 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
FI62666C (en) 1983-02-10
FR2308367B1 (en) 1979-09-21
ZA762320B (en) 1977-11-30
AT353795B (en) 1979-12-10
DE2617205A1 (en) 1976-10-28
PH12274A (en) 1978-12-12
CA1059128A (en) 1979-07-24
EG12387A (en) 1978-12-31
ES459405A1 (en) 1978-08-16
YU100676A (en) 1982-08-31
HK60380A (en) 1980-11-07
DE2617205B2 (en) 1980-05-08
GB1492528A (en) 1977-11-23
JPS51136688A (en) 1976-11-26
PL99664B1 (en) 1978-07-31
PT65027B (en) 1978-04-03
CY1090A (en) 1980-12-27
DE2617205C3 (en) 1981-01-29
AU496854B2 (en) 1978-11-02
SU638260A3 (en) 1978-12-15
MY8100225A (en) 1981-12-31
JPS5522475B2 (en) 1980-06-17
IE42979L (en) 1976-10-21
PT65027A (en) 1976-05-01
BE840904A (en) 1976-08-16
IE42979B1 (en) 1980-11-19
RO73278A (en) 1982-09-09
NL7603800A (en) 1976-10-25
NO146599C (en) 1982-11-03
GR59900B (en) 1978-03-16
ATA288376A (en) 1979-05-15
HU172684B (en) 1978-11-28
DK143899C (en) 1982-04-13
AU1296676A (en) 1977-10-20
FI62666B (en) 1982-10-29
BG34185A3 (en) 1983-07-15
FR2308367A1 (en) 1976-11-19
IL49391A0 (en) 1976-06-30
NL167692B (en) 1981-08-17
SE421695B (en) 1982-01-25
KE3088A (en) 1980-11-07
DK143899B (en) 1981-10-26
CS195726B2 (en) 1980-02-29
DD124599A5 (en) 1977-03-02
AR210349A1 (en) 1977-07-29
CH619462A5 (en) 1980-09-30
SE7604093L (en) 1976-10-22
FI760978A (en) 1976-10-22
ES459406A1 (en) 1978-08-16
NL167692C (en) 1982-01-18
DK164476A (en) 1976-10-22
NO146599B (en) 1982-07-26
IL49391A (en) 1979-09-30
ES447150A1 (en) 1977-09-16
NO761207L (en) 1976-10-22
LU74795A1 (en) 1977-02-07

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