ES459405A1 - A PROCEDURE FOR THE PREPARATION OF A COMPOUND OF PI- PERAZINILPIRAZINA. - Google Patents
A PROCEDURE FOR THE PREPARATION OF A COMPOUND OF PI- PERAZINILPIRAZINA.Info
- Publication number
- ES459405A1 ES459405A1 ES459405A ES459405A ES459405A1 ES 459405 A1 ES459405 A1 ES 459405A1 ES 459405 A ES459405 A ES 459405A ES 459405 A ES459405 A ES 459405A ES 459405 A1 ES459405 A1 ES 459405A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- preparation
- perazinilpirazina
- procedure
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- -1 pyrazine compound Chemical class 0.000 abstract 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de piperazimil)pirazina de fórmula (* ver imagen 1) caracterizado por: Hidrolizar un compuesto de fórmula (* ver imagen 2) donde R5alfa es un heterociclo, alcanoílo, aroílo, carboalcoxi, ciano, carbamilo, N-alquilcarbamilo o N-arilcarbamilo.A process for the preparation of a piperazimyl)pyrazine compound of formula (* see image 1) characterized by: Hydrolyzing a compound of formula (* see image 2) where R5alpha is a heterocycle, alkanoyl, aroyl, carboalkoxy, cyano, carbamyl, N-alkylcarbamyl or N-arylcarbamyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57005275A | 1975-04-21 | 1975-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459405A1 true ES459405A1 (en) | 1978-08-16 |
Family
ID=24277994
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447150A Expired ES447150A1 (en) | 1975-04-21 | 1976-04-19 | Pyrazinyl piperazine derivatives |
| ES459406A Expired ES459406A1 (en) | 1975-04-21 | 1977-06-01 | A PROCEDURE FOR THE PREPARATION OF A COMPOUND OF PI- PERAZINILPIRAZINA. |
| ES459407A Expired ES459407A1 (en) | 1975-04-21 | 1977-06-01 | Pyrazinyl piperazine derivatives |
| ES459405A Expired ES459405A1 (en) | 1975-04-21 | 1977-06-01 | A PROCEDURE FOR THE PREPARATION OF A COMPOUND OF PI- PERAZINILPIRAZINA. |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447150A Expired ES447150A1 (en) | 1975-04-21 | 1976-04-19 | Pyrazinyl piperazine derivatives |
| ES459406A Expired ES459406A1 (en) | 1975-04-21 | 1977-06-01 | A PROCEDURE FOR THE PREPARATION OF A COMPOUND OF PI- PERAZINILPIRAZINA. |
| ES459407A Expired ES459407A1 (en) | 1975-04-21 | 1977-06-01 | Pyrazinyl piperazine derivatives |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS51136688A (en) |
| AR (1) | AR210349A1 (en) |
| AT (1) | AT353795B (en) |
| AU (1) | AU496854B2 (en) |
| BE (1) | BE840904A (en) |
| BG (1) | BG34185A3 (en) |
| CA (1) | CA1059128A (en) |
| CH (1) | CH619462A5 (en) |
| CS (1) | CS195726B2 (en) |
| CY (1) | CY1090A (en) |
| DD (1) | DD124599A5 (en) |
| DE (1) | DE2617205C3 (en) |
| DK (1) | DK143899C (en) |
| EG (1) | EG12387A (en) |
| ES (4) | ES447150A1 (en) |
| FI (1) | FI62666C (en) |
| FR (1) | FR2308367A1 (en) |
| GB (1) | GB1492528A (en) |
| GR (1) | GR59900B (en) |
| HK (1) | HK60380A (en) |
| HU (1) | HU172684B (en) |
| IE (1) | IE42979B1 (en) |
| IL (1) | IL49391A (en) |
| KE (1) | KE3088A (en) |
| LU (1) | LU74795A1 (en) |
| MY (1) | MY8100225A (en) |
| NL (1) | NL167692C (en) |
| NO (1) | NO146599C (en) |
| PH (1) | PH12274A (en) |
| PL (1) | PL99664B1 (en) |
| PT (1) | PT65027B (en) |
| RO (1) | RO73278A (en) |
| SE (1) | SE421695B (en) |
| SU (1) | SU638260A3 (en) |
| YU (1) | YU100676A (en) |
| ZA (1) | ZA762320B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| US4252816A (en) * | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| EP0580465A1 (en) * | 1992-06-25 | 1994-01-26 | Sanofi | New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives |
| DK1027336T3 (en) | 1997-10-27 | 2005-01-24 | Neurosearch As | Heter Garyldiazacycloalkanes, their preparation and use |
| EP1175416B1 (en) | 1999-04-26 | 2003-07-16 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
| HRP20020747A2 (en) * | 2000-02-16 | 2004-12-31 | Neurogen Corp | Substituted arylpyrazines |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| SE0202287D0 (en) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
| BR0312789A (en) | 2002-07-19 | 2005-05-03 | Biovitrum Ab | New piperazinyl pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
-
1976
- 1976-04-07 SE SE7604093A patent/SE421695B/en not_active IP Right Cessation
- 1976-04-07 DK DK164476A patent/DK143899C/en not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/en active
- 1976-04-08 NO NO761207A patent/NO146599C/en unknown
- 1976-04-09 FI FI760978A patent/FI62666C/en not_active IP Right Cessation
- 1976-04-09 NL NL7603800A patent/NL167692C/en not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/en unknown
- 1976-04-13 GR GR50538A patent/GR59900B/en unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/en active Granted
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 CY CY1090A patent/CY1090A/en unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/en unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/en active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/en not_active Expired
- 1976-04-20 ZA ZA762320A patent/ZA762320B/en unknown
- 1976-04-20 RO RO7685688A patent/RO73278A/en unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/en unknown
- 1976-04-20 BE BE166282A patent/BE840904A/en not_active IP Right Cessation
- 1976-04-20 YU YU01006/76A patent/YU100676A/en unknown
- 1976-04-20 BG BG032968A patent/BG34185A3/en unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/en active
- 1976-04-20 DE DE2617205A patent/DE2617205C3/en not_active Expired
- 1976-04-20 AR AR262930A patent/AR210349A1/en active
- 1976-04-20 AT AT288376A patent/AT353795B/en not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 CH CH492676A patent/CH619462A5/en not_active IP Right Cessation
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/en unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
-
1977
- 1977-06-01 ES ES459406A patent/ES459406A1/en not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/en not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/en not_active Expired
-
1980
- 1980-10-02 KE KE3088A patent/KE3088A/en unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/en unknown
-
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/en unknown
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