SU638260A3 - Method of obtaining 6-chlor-2-(1'-piperazinyl)pyrazine - Google Patents

Method of obtaining 6-chlor-2-(1'-piperazinyl)pyrazine

Info

Publication number
SU638260A3
SU638260A3 SU762346054A SU2346054A SU638260A3 SU 638260 A3 SU638260 A3 SU 638260A3 SU 762346054 A SU762346054 A SU 762346054A SU 2346054 A SU2346054 A SU 2346054A SU 638260 A3 SU638260 A3 SU 638260A3
Authority
SU
USSR - Soviet Union
Prior art keywords
chlor
pyrazine
piperazinyl
obtaining
temperature
Prior art date
Application number
SU762346054A
Other languages
Russian (ru)
Inventor
Спенсер Саари Уолфред
Карл Ламма Уильям (Младший)
Original Assignee
Мерк Энд Ко Инк (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко Инк (Фирма) filed Critical Мерк Энд Ко Инк (Фирма)
Application granted granted Critical
Publication of SU638260A3 publication Critical patent/SU638260A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Description

3 заключающийс  в том, что производное пкРазина формулы II Cl X. 4 где X - галоид, подвергают взапмодеиствию с пиперазином в инертной атмосфере при температуре от комнатной до 90° С.3 consisting in the fact that the pcRazine derivative of the formula II Cl X. 4 where X is halogen, is subjected to inhibition with piperazine in an inert atmosphere at a temperature from room temperature to 90 ° C.

SU762346054A 1975-04-21 1976-04-20 Method of obtaining 6-chlor-2-(1'-piperazinyl)pyrazine SU638260A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (1)

Publication Number Publication Date
SU638260A3 true SU638260A3 (en) 1978-12-15

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
SU762346054A SU638260A3 (en) 1975-04-21 1976-04-20 Method of obtaining 6-chlor-2-(1'-piperazinyl)pyrazine

Country Status (36)

Country Link
JP (1) JPS51136688A (en)
AR (1) AR210349A1 (en)
AT (1) AT353795B (en)
AU (1) AU496854B2 (en)
BE (1) BE840904A (en)
BG (1) BG34185A3 (en)
CA (1) CA1059128A (en)
CH (1) CH619462A5 (en)
CS (1) CS195726B2 (en)
CY (1) CY1090A (en)
DD (1) DD124599A5 (en)
DE (1) DE2617205C3 (en)
DK (1) DK143899C (en)
EG (1) EG12387A (en)
ES (4) ES447150A1 (en)
FI (1) FI62666C (en)
FR (1) FR2308367A1 (en)
GB (1) GB1492528A (en)
GR (1) GR59900B (en)
HK (1) HK60380A (en)
HU (1) HU172684B (en)
IE (1) IE42979B1 (en)
IL (1) IL49391A (en)
KE (1) KE3088A (en)
LU (1) LU74795A1 (en)
MY (1) MY8100225A (en)
NL (1) NL167692C (en)
NO (1) NO146599C (en)
PH (1) PH12274A (en)
PL (1) PL99664B1 (en)
PT (1) PT65027B (en)
RO (1) RO73278A (en)
SE (1) SE421695B (en)
SU (1) SU638260A3 (en)
YU (1) YU100676A (en)
ZA (1) ZA762320B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (en) * 1992-06-25 1994-01-26 Sanofi New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives
DK1027336T3 (en) * 1997-10-27 2005-01-24 Neurosearch As Heter Garyldiazacycloalkanes, their preparation and use
ATE245153T1 (en) 1999-04-26 2003-08-15 Neurosearch As HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE
AP2002002620A0 (en) * 2000-02-16 2002-09-30 Neurogen Corp Substituted arylpyrazines
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (en) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
NZ537629A (en) 2002-07-19 2007-05-31 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
FI62666C (en) 1983-02-10
FR2308367B1 (en) 1979-09-21
ZA762320B (en) 1977-11-30
ES459407A1 (en) 1978-08-16
AT353795B (en) 1979-12-10
DE2617205A1 (en) 1976-10-28
PH12274A (en) 1978-12-12
CA1059128A (en) 1979-07-24
EG12387A (en) 1978-12-31
ES459405A1 (en) 1978-08-16
YU100676A (en) 1982-08-31
HK60380A (en) 1980-11-07
DE2617205B2 (en) 1980-05-08
GB1492528A (en) 1977-11-23
JPS51136688A (en) 1976-11-26
PL99664B1 (en) 1978-07-31
PT65027B (en) 1978-04-03
CY1090A (en) 1980-12-27
DE2617205C3 (en) 1981-01-29
AU496854B2 (en) 1978-11-02
MY8100225A (en) 1981-12-31
JPS5522475B2 (en) 1980-06-17
IE42979L (en) 1976-10-21
PT65027A (en) 1976-05-01
BE840904A (en) 1976-08-16
IE42979B1 (en) 1980-11-19
RO73278A (en) 1982-09-09
NL7603800A (en) 1976-10-25
NO146599C (en) 1982-11-03
GR59900B (en) 1978-03-16
ATA288376A (en) 1979-05-15
HU172684B (en) 1978-11-28
DK143899C (en) 1982-04-13
AU1296676A (en) 1977-10-20
FI62666B (en) 1982-10-29
BG34185A3 (en) 1983-07-15
FR2308367A1 (en) 1976-11-19
IL49391A0 (en) 1976-06-30
NL167692B (en) 1981-08-17
SE421695B (en) 1982-01-25
KE3088A (en) 1980-11-07
DK143899B (en) 1981-10-26
CS195726B2 (en) 1980-02-29
DD124599A5 (en) 1977-03-02
AR210349A1 (en) 1977-07-29
CH619462A5 (en) 1980-09-30
SE7604093L (en) 1976-10-22
FI760978A (en) 1976-10-22
ES459406A1 (en) 1978-08-16
NL167692C (en) 1982-01-18
DK164476A (en) 1976-10-22
NO146599B (en) 1982-07-26
IL49391A (en) 1979-09-30
ES447150A1 (en) 1977-09-16
NO761207L (en) 1976-10-22
LU74795A1 (en) 1977-02-07

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