JPS51136688A - Anorexia compound or piperazinylpyrazine - Google Patents

Anorexia compound or piperazinylpyrazine

Info

Publication number
JPS51136688A
JPS51136688A JP51043763A JP4376376A JPS51136688A JP S51136688 A JPS51136688 A JP S51136688A JP 51043763 A JP51043763 A JP 51043763A JP 4376376 A JP4376376 A JP 4376376A JP S51136688 A JPS51136688 A JP S51136688A
Authority
JP
Japan
Prior art keywords
piperazinylpyrazine
anorexia
compound
anorexia compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51043763A
Other languages
Japanese (ja)
Other versions
JPS5522475B2 (en
Inventor
Supensaa Saari Uorufuretsudo
Kaaru Rumuma Jiyunia Uiriamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS51136688A publication Critical patent/JPS51136688A/en
Publication of JPS5522475B2 publication Critical patent/JPS5522475B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20Nitrogen atoms
JP51043763A 1975-04-21 1976-04-19 Anorexia compound or piperazinylpyrazine Granted JPS51136688A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (2)

Publication Number Publication Date
JPS51136688A true JPS51136688A (en) 1976-11-26
JPS5522475B2 JPS5522475B2 (en) 1980-06-17

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51043763A Granted JPS51136688A (en) 1975-04-21 1976-04-19 Anorexia compound or piperazinylpyrazine

Country Status (36)

Country Link
JP (1) JPS51136688A (en)
AR (1) AR210349A1 (en)
AT (1) AT353795B (en)
AU (1) AU496854B2 (en)
BE (1) BE840904A (en)
BG (1) BG34185A3 (en)
CA (1) CA1059128A (en)
CH (1) CH619462A5 (en)
CS (1) CS195726B2 (en)
CY (1) CY1090A (en)
DD (1) DD124599A5 (en)
DE (1) DE2617205C3 (en)
DK (1) DK143899C (en)
EG (1) EG12387A (en)
ES (4) ES447150A1 (en)
FI (1) FI62666C (en)
FR (1) FR2308367A1 (en)
GB (1) GB1492528A (en)
GR (1) GR59900B (en)
HK (1) HK60380A (en)
HU (1) HU172684B (en)
IE (1) IE42979B1 (en)
IL (1) IL49391A (en)
KE (1) KE3088A (en)
LU (1) LU74795A1 (en)
MY (1) MY8100225A (en)
NL (1) NL167692C (en)
NO (1) NO146599C (en)
PH (1) PH12274A (en)
PL (1) PL99664B1 (en)
PT (1) PT65027B (en)
RO (1) RO73278A (en)
SE (1) SE421695B (en)
SU (1) SU638260A3 (en)
YU (1) YU100676A (en)
ZA (1) ZA762320B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001521025A (en) * 1997-10-27 2001-11-06 ニューロサーチ、アクティーゼルスカブ Heteroaryldiazacycloalkanes as cholinergic ligands at the nicotinic acetylcholine receptor
JP2004500383A (en) * 2000-02-16 2004-01-08 ニューロゲン コーポレイション Substituted arylpyrazine

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (en) * 1992-06-25 1994-01-26 Sanofi New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives
ATE245153T1 (en) 1999-04-26 2003-08-15 Neurosearch As HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (en) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
NZ537629A (en) 2002-07-19 2007-05-31 Biovitrum Ab Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001521025A (en) * 1997-10-27 2001-11-06 ニューロサーチ、アクティーゼルスカブ Heteroaryldiazacycloalkanes as cholinergic ligands at the nicotinic acetylcholine receptor
JP2004500383A (en) * 2000-02-16 2004-01-08 ニューロゲン コーポレイション Substituted arylpyrazine

Also Published As

Publication number Publication date
FI62666C (en) 1983-02-10
FR2308367B1 (en) 1979-09-21
ZA762320B (en) 1977-11-30
ES459407A1 (en) 1978-08-16
AT353795B (en) 1979-12-10
DE2617205A1 (en) 1976-10-28
PH12274A (en) 1978-12-12
CA1059128A (en) 1979-07-24
EG12387A (en) 1978-12-31
ES459405A1 (en) 1978-08-16
YU100676A (en) 1982-08-31
HK60380A (en) 1980-11-07
DE2617205B2 (en) 1980-05-08
GB1492528A (en) 1977-11-23
PL99664B1 (en) 1978-07-31
PT65027B (en) 1978-04-03
CY1090A (en) 1980-12-27
DE2617205C3 (en) 1981-01-29
AU496854B2 (en) 1978-11-02
SU638260A3 (en) 1978-12-15
MY8100225A (en) 1981-12-31
JPS5522475B2 (en) 1980-06-17
IE42979L (en) 1976-10-21
PT65027A (en) 1976-05-01
BE840904A (en) 1976-08-16
IE42979B1 (en) 1980-11-19
RO73278A (en) 1982-09-09
NL7603800A (en) 1976-10-25
NO146599C (en) 1982-11-03
GR59900B (en) 1978-03-16
ATA288376A (en) 1979-05-15
HU172684B (en) 1978-11-28
DK143899C (en) 1982-04-13
AU1296676A (en) 1977-10-20
FI62666B (en) 1982-10-29
BG34185A3 (en) 1983-07-15
FR2308367A1 (en) 1976-11-19
IL49391A0 (en) 1976-06-30
NL167692B (en) 1981-08-17
SE421695B (en) 1982-01-25
KE3088A (en) 1980-11-07
DK143899B (en) 1981-10-26
CS195726B2 (en) 1980-02-29
DD124599A5 (en) 1977-03-02
AR210349A1 (en) 1977-07-29
CH619462A5 (en) 1980-09-30
SE7604093L (en) 1976-10-22
FI760978A (en) 1976-10-22
ES459406A1 (en) 1978-08-16
NL167692C (en) 1982-01-18
DK164476A (en) 1976-10-22
NO146599B (en) 1982-07-26
IL49391A (en) 1979-09-30
ES447150A1 (en) 1977-09-16
NO761207L (en) 1976-10-22
LU74795A1 (en) 1977-02-07

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