CH619364A5 - - Google Patents
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- Publication number
- CH619364A5 CH619364A5 CH415276A CH415276A CH619364A5 CH 619364 A5 CH619364 A5 CH 619364A5 CH 415276 A CH415276 A CH 415276A CH 415276 A CH415276 A CH 415276A CH 619364 A5 CH619364 A5 CH 619364A5
- Authority
- CH
- Switzerland
- Prior art keywords
- theophylline
- solution
- pure
- weight
- dissolved
- Prior art date
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 41
- 239000000243 solution Substances 0.000 claims 20
- 229960000278 theophylline Drugs 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 230000007935 neutral effect Effects 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 7
- 239000000047 product Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960004767 proxyphylline Drugs 0.000 claims 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- KYHQZNGJUGFTGR-UHFFFAOYSA-N Proxyphylline Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2CC(O)C KYHQZNGJUGFTGR-UHFFFAOYSA-N 0.000 claims 2
- 239000012670 alkaline solution Substances 0.000 claims 2
- 239000012153 distilled water Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- KYHQZNGJUGFTGR-LURJTMIESA-N 7-[(2s)-2-hydroxypropyl]-1,3-dimethylpurine-2,6-dione Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C[C@@H](O)C KYHQZNGJUGFTGR-LURJTMIESA-N 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- -1 aliphatic amines Chemical class 0.000 claims 1
- 229960003556 aminophylline Drugs 0.000 claims 1
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000000572 bronchospasmolytic effect Effects 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960002819 diprophylline Drugs 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH415276A CH619364A5 (OSRAM) | 1976-04-02 | 1976-04-02 | |
| DE19762634335 DE2634335A1 (de) | 1976-04-02 | 1976-07-30 | Verfahren zur herstellung von stabilisierten, reines theophyllin in rein waessrigem, neutralen milieu enthaltenden loesungen |
| PT65684A PT65684B (de) | 1976-04-02 | 1976-10-07 | Verfahren zur herstellung von stabilisierten reines theophyllin rein wassrigem neutralem milieu enthaltenden losungen |
| ZA766679A ZA766679B (en) | 1976-04-02 | 1976-11-08 | Process for the production of stabilized pure theophylline in neutral aqueous solution |
| US05/740,672 US4117132A (en) | 1976-04-02 | 1976-11-10 | Process for the production of stabilized pure theophylline in neutral, aqueous solution |
| FR7703582A FR2346012A1 (fr) | 1976-04-02 | 1977-02-09 | Nouvelles compositions de theophylline et leur procede de preparation |
| IL51756A IL51756A0 (en) | 1976-04-02 | 1977-03-28 | A pure stable neutral aqueous solution of theophylline and process and compositions for preparing it |
| AU23744/77A AU511564B2 (en) | 1976-04-02 | 1977-03-29 | Process for preparing a stable, neutral aqueous solution of theophylline |
| SE7703716A SE7703716L (sv) | 1976-04-02 | 1977-03-30 | Forfarande for framstellning av stabiliserat, rent teofyllin i losningar innehallande rent vattenbaserat, neutralt medium |
| IN486/CAL/77A IN146003B (OSRAM) | 1976-04-02 | 1977-03-30 | |
| NL7703485A NL7703485A (nl) | 1976-04-02 | 1977-03-30 | Werkwijze ter bereiding van gestabiliseerde oplossingen, die zuiver theofylline in zuiver waterig neutraal milieu bevatten. |
| BE176318A BE853115A (fr) | 1976-04-02 | 1977-03-31 | Nouvelles compositions de theophylline et leur procede de preparation |
| AT226277A AT352882B (de) | 1976-04-02 | 1977-03-31 | Verfahren zur herstellung einer stabilisierten theophyllin enthaltenden waesserigen loesung |
| GB13870/77A GB1561524A (en) | 1976-04-02 | 1977-04-01 | Theophylline compositions |
| JP3623377A JPS52128209A (en) | 1976-04-02 | 1977-04-01 | Production of theophiline neutral solution and solid composition |
| CS772197A CS196356B2 (en) | 1976-04-02 | 1977-04-01 | Process for preparing stable neutral aqueous solution containing pure theophylline |
| GR53138A GR63087B (en) | 1976-04-02 | 1977-04-01 | Preparation process of stabilised,pure theophyllin in solutions containing pure aqueous neutral agent |
| CA275,347A CA1078735A (en) | 1976-04-02 | 1977-04-01 | Process for the production of a stabilized solution of theophylline |
| DK144877A DK144877A (da) | 1976-04-02 | 1977-04-01 | Fremgangsmade til fremstilling af en stabil neutral vandig oplosning indeholdende rent theophylin en saledes fremstillet oplosning og dennes anvendelse |
| ES457450A ES457450A1 (es) | 1976-04-02 | 1977-04-01 | Procedimiento para fabricar una solucion acuosa, estable y neutra, conteniendo teofilina pura. |
| NO771175A NO771175L (no) | 1976-04-02 | 1977-04-01 | Fremgangsm}te ved fremstilling av stabilisert, rent theofyllin i oppl¦sninger inneholdende rent vandig, n¦ytralt milj¦ |
| IE701/77A IE44733B1 (en) | 1976-04-02 | 1977-04-01 | Theophylline compositions |
| AR267102A AR212466A1 (es) | 1976-04-02 | 1977-04-04 | Procedimiento de preparacion de una solucion ocuosa de teofilina pura,estable y neutra |
| CS791364A CS203949B2 (cs) | 1976-04-02 | 1979-02-28 | Způsob výroby farmaceutického prostředku obsahujícího Čistý theofyllln |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH415276A CH619364A5 (OSRAM) | 1976-04-02 | 1976-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH619364A5 true CH619364A5 (OSRAM) | 1980-09-30 |
Family
ID=4270779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH415276A CH619364A5 (OSRAM) | 1976-04-02 | 1976-04-02 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4117132A (OSRAM) |
| JP (1) | JPS52128209A (OSRAM) |
| AR (1) | AR212466A1 (OSRAM) |
| AT (1) | AT352882B (OSRAM) |
| AU (1) | AU511564B2 (OSRAM) |
| BE (1) | BE853115A (OSRAM) |
| CA (1) | CA1078735A (OSRAM) |
| CH (1) | CH619364A5 (OSRAM) |
| CS (1) | CS196356B2 (OSRAM) |
| DE (1) | DE2634335A1 (OSRAM) |
| DK (1) | DK144877A (OSRAM) |
| ES (1) | ES457450A1 (OSRAM) |
| FR (1) | FR2346012A1 (OSRAM) |
| GB (1) | GB1561524A (OSRAM) |
| GR (1) | GR63087B (OSRAM) |
| IE (1) | IE44733B1 (OSRAM) |
| IL (1) | IL51756A0 (OSRAM) |
| IN (1) | IN146003B (OSRAM) |
| NL (1) | NL7703485A (OSRAM) |
| NO (1) | NO771175L (OSRAM) |
| PT (1) | PT65684B (OSRAM) |
| SE (1) | SE7703716L (OSRAM) |
| ZA (1) | ZA766679B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364922A (en) * | 1980-10-14 | 1982-12-21 | University Of Virginia Alumni Patents Foundation | Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances |
| DE3432112A1 (de) * | 1984-08-29 | 1986-03-13 | Asche Ag | Injektionsloesung |
| DE3827362A1 (de) * | 1988-08-12 | 1990-02-15 | Basf Ag | Pulvrige, hydrophile theophyllinformulierung und verfahren zur ihrer herstellung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3823229A (en) * | 1970-11-20 | 1974-07-09 | Pharmacia Ab | Inhalation compositions containing 7-(beta-hydroxypropyl)-theophylline |
| US3928609A (en) * | 1973-04-05 | 1975-12-23 | Dooner Lab | Non-alcoholic theophylline product |
-
1976
- 1976-04-02 CH CH415276A patent/CH619364A5/de not_active IP Right Cessation
- 1976-07-30 DE DE19762634335 patent/DE2634335A1/de not_active Withdrawn
- 1976-10-07 PT PT65684A patent/PT65684B/pt unknown
- 1976-11-08 ZA ZA766679A patent/ZA766679B/xx unknown
- 1976-11-10 US US05/740,672 patent/US4117132A/en not_active Expired - Lifetime
-
1977
- 1977-02-09 FR FR7703582A patent/FR2346012A1/fr not_active Withdrawn
- 1977-03-28 IL IL51756A patent/IL51756A0/xx unknown
- 1977-03-29 AU AU23744/77A patent/AU511564B2/en not_active Expired
- 1977-03-30 NL NL7703485A patent/NL7703485A/xx not_active Application Discontinuation
- 1977-03-30 SE SE7703716A patent/SE7703716L/xx unknown
- 1977-03-30 IN IN486/CAL/77A patent/IN146003B/en unknown
- 1977-03-31 BE BE176318A patent/BE853115A/xx unknown
- 1977-03-31 AT AT226277A patent/AT352882B/de active
- 1977-04-01 CA CA275,347A patent/CA1078735A/en not_active Expired
- 1977-04-01 ES ES457450A patent/ES457450A1/es not_active Expired
- 1977-04-01 JP JP3623377A patent/JPS52128209A/ja active Pending
- 1977-04-01 GR GR53138A patent/GR63087B/el unknown
- 1977-04-01 DK DK144877A patent/DK144877A/da not_active IP Right Cessation
- 1977-04-01 NO NO771175A patent/NO771175L/no unknown
- 1977-04-01 GB GB13870/77A patent/GB1561524A/en not_active Expired
- 1977-04-01 CS CS772197A patent/CS196356B2/cs unknown
- 1977-04-01 IE IE701/77A patent/IE44733B1/en unknown
- 1977-04-04 AR AR267102A patent/AR212466A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2346012A1 (fr) | 1977-10-28 |
| SE7703716L (sv) | 1977-10-03 |
| NL7703485A (nl) | 1977-10-04 |
| AU511564B2 (en) | 1980-08-28 |
| AT352882B (de) | 1979-10-10 |
| BE853115A (fr) | 1977-07-18 |
| GR63087B (en) | 1979-08-09 |
| ES457450A1 (es) | 1978-04-01 |
| PT65684A (de) | 1976-11-01 |
| US4117132A (en) | 1978-09-26 |
| AU2374477A (en) | 1978-10-05 |
| DK144877A (da) | 1977-10-03 |
| DE2634335A1 (de) | 1977-10-06 |
| IE44733B1 (en) | 1982-03-10 |
| NO771175L (no) | 1977-10-04 |
| JPS52128209A (en) | 1977-10-27 |
| AR212466A1 (es) | 1978-07-14 |
| CA1078735A (en) | 1980-06-03 |
| GB1561524A (en) | 1980-02-20 |
| CS196356B2 (en) | 1980-03-31 |
| ZA766679B (en) | 1977-10-26 |
| IL51756A0 (en) | 1977-05-31 |
| IN146003B (OSRAM) | 1979-02-03 |
| PT65684B (de) | 1978-04-14 |
| ATA226277A (de) | 1979-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |