CH615158A5 - - Google Patents

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Publication number
CH615158A5
CH615158A5 CH1268975A CH1268975A CH615158A5 CH 615158 A5 CH615158 A5 CH 615158A5 CH 1268975 A CH1268975 A CH 1268975A CH 1268975 A CH1268975 A CH 1268975A CH 615158 A5 CH615158 A5 CH 615158A5
Authority
CH
Switzerland
Prior art keywords
acetic acid
fluoro
acid
methyl
reaction
Prior art date
Application number
CH1268975A
Other languages
German (de)
English (en)
Inventor
Roger James Tull
David Gregory Melillo
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH615158A5 publication Critical patent/CH615158A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen
CH1268975A 1974-10-02 1975-09-30 CH615158A5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/511,349 US3998875A (en) 1974-10-02 1974-10-02 Process of preparing 5-fluoro-2-methyl-1-(paramethylsulfinylbenzylidene)-indenyl-3-acetic acid

Publications (1)

Publication Number Publication Date
CH615158A5 true CH615158A5 (es) 1980-01-15

Family

ID=24034513

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1268975A CH615158A5 (es) 1974-10-02 1975-09-30

Country Status (21)

Country Link
US (2) US3998875A (es)
JP (1) JPS51105049A (es)
AT (1) AT344154B (es)
BE (1) BE834080A (es)
CH (1) CH615158A5 (es)
CS (2) CS183821B2 (es)
DD (1) DD125639A5 (es)
DE (1) DE2543870A1 (es)
DK (1) DK416975A (es)
ES (1) ES441404A1 (es)
FI (1) FI61690C (es)
FR (1) FR2286817A1 (es)
GB (1) GB1483980A (es)
HU (1) HU171805B (es)
LU (1) LU73496A1 (es)
NL (1) NL7510944A (es)
NO (2) NO141050C (es)
PL (2) PL103093B1 (es)
SE (1) SE7510329L (es)
SU (3) SU860695A1 (es)
YU (2) YU239875A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206241A1 (en) * 1985-06-19 1986-12-30 ZAMBON S.p.A. Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4368127A (en) * 1979-07-02 1983-01-11 Akzona Incorporated Fabric softening compounds and method
EP0071006B1 (en) * 1981-06-11 1985-09-18 Sumitomo Chemical Company, Limited Tetrahydronaphthalene derivatives and their production
US5965619A (en) * 1996-06-13 1999-10-12 Cell Pathways Inc. Method for treating patients having precancerous lesions with substituted indene derivatives
US5998477A (en) * 1996-06-13 1999-12-07 Cell Pathways Inc. Substituted methoxy benzylidene indenyl-acetic and propionic acids for treating patients with precancerous lesions
US6063818A (en) * 1996-06-13 2000-05-16 Cell Pathways Inc. Substituted benzylidene indenyl formamides, acetamides and propionamides
US6121321A (en) * 1996-06-13 2000-09-19 Cell Pathways, Inc. Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
ES2250578T3 (es) * 1996-07-01 2006-04-16 THE PROCTER & GAMBLE COMPANY Procedimiento para preparar escamas de patata deshidratadas.
US5948779A (en) * 1997-12-12 1999-09-07 Cell Pathways, Inc. Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532752A (en) * 1965-12-30 1970-10-06 Merck & Co Inc 1-alkylidene-3-indenyl aliphatic amines
US3547923A (en) * 1968-03-25 1970-12-15 Bristol Myers Co Piperazyl ethyl 7h-benzocycloheptenes
US3692825A (en) * 1970-05-01 1972-09-19 Merck & Co Inc Indanyl acetic acids
US3654349A (en) * 1970-05-01 1972-04-04 Merck & Co Inc Substituted indenyl acetic acids
US3766259A (en) * 1970-05-01 1973-10-16 Merck & Co Inc Preparation of 1-aryl-3-indenyl acetic acids
US3725548A (en) * 1970-05-01 1973-04-03 Merck & Co Inc Substituted indenyl acetic acids in the treatment of pain, fever or inflammation
US3870753A (en) * 1973-12-20 1975-03-11 Merck & Co Inc Process for preparing indenyl acetic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206241A1 (en) * 1985-06-19 1986-12-30 ZAMBON S.p.A. Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid

Also Published As

Publication number Publication date
FI61690C (fi) 1982-09-10
CS183850B2 (en) 1978-07-31
NO141050B (no) 1979-09-24
LU73496A1 (es) 1976-08-19
HU171805B (hu) 1978-03-28
JPS51105049A (en) 1976-09-17
DD125639A5 (es) 1977-05-04
ATA734575A (de) 1977-11-15
US3998875A (en) 1976-12-21
DK416975A (da) 1976-04-03
DE2543870A1 (de) 1976-04-22
BE834080A (fr) 1976-04-01
ES441404A1 (es) 1977-03-01
FI61690B (fi) 1982-05-31
PL103733B1 (pl) 1979-07-31
FR2286817A1 (fr) 1976-04-30
FR2286817B1 (es) 1979-01-05
SE7510329L (sv) 1976-04-05
YU239875A (en) 1982-06-30
NO753179L (es) 1976-04-05
NL7510944A (nl) 1976-04-06
YU141481A (en) 1982-02-28
NO146198C (no) 1982-08-18
SU860695A1 (ru) 1981-08-30
NO141050C (no) 1980-01-02
GB1483980A (en) 1977-08-24
US4123457A (en) 1978-10-31
SU995705A3 (ru) 1983-02-07
SU957760A3 (ru) 1982-09-07
NO791267L (no) 1976-04-05
CS183821B2 (en) 1978-07-31
AT344154B (de) 1978-07-10
FI752573A (es) 1976-04-03
NO146198B (no) 1982-05-10
PL103093B1 (pl) 1979-05-31

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PL Patent ceased