CH462835A - Verfahren zur Herstellung von neuen Triazaspirodecanen und ihren Säureadditionssalzen - Google Patents

Verfahren zur Herstellung von neuen Triazaspirodecanen und ihren Säureadditionssalzen

Info

Publication number
CH462835A
CH462835A CH776363A CH776363A CH462835A CH 462835 A CH462835 A CH 462835A CH 776363 A CH776363 A CH 776363A CH 776363 A CH776363 A CH 776363A CH 462835 A CH462835 A CH 462835A
Authority
CH
Switzerland
Prior art keywords
parts
phenyl
oxo
spiro
triaza
Prior art date
Application number
CH776363A
Other languages
German (de)
English (en)
Inventor
Jan Janssen Paul Adrian
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CH462835A publication Critical patent/CH462835A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Wire Processing (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH776363A 1962-06-22 1963-06-21 Verfahren zur Herstellung von neuen Triazaspirodecanen und ihren Säureadditionssalzen CH462835A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20462362A 1962-06-22 1962-06-22

Publications (1)

Publication Number Publication Date
CH462835A true CH462835A (de) 1968-09-30

Family

ID=22758700

Family Applications (1)

Application Number Title Priority Date Filing Date
CH776363A CH462835A (de) 1962-06-22 1963-06-21 Verfahren zur Herstellung von neuen Triazaspirodecanen und ihren Säureadditionssalzen

Country Status (9)

Country Link
BE (1) BE633914A (ja)
CH (1) CH462835A (ja)
DE (1) DE1470125C3 (ja)
DK (1) DK119880B (ja)
FI (1) FI46967C (ja)
FR (6) FR1573808A (ja)
GB (1) GB1043141A (ja)
NO (1) NO117368B (ja)
SE (1) SE311019B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121972A2 (en) * 1983-04-11 1984-10-17 Janssen Pharmaceutica N.V. N-aryl-alpha-amino-carboxamides

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080328A (en) * 1971-07-13 1978-03-21 Sumitomo Chemical Company, Limited N-substituted heterocyclic derivatives and preparation thereof
BE792187A (fr) * 1971-12-03 1973-03-30 Sumitomo Chemical Co Nouveaux derives d'alkylamines
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
NZ181256A (en) * 1975-07-21 1978-04-28 Janssen Pharmaceutica Nv 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5244902A (en) * 1989-08-21 1993-09-14 Beth Israel Hospital Association Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
DE19610397A1 (de) * 1996-03-16 1997-09-18 Krewel Meuselbach Gmbh Gewinnung von Fluspirilen-Suspensionen
JP2002515503A (ja) * 1998-05-18 2002-05-28 ノボ ノルディスク アクティーゼルスカブ オピオイド受容体のサブタイプへの高い親和性を有する新規１，３，８−トリアザスピロ〔４，５〕デカノン
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
EP0997464B1 (en) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
US7459461B2 (en) 2001-10-19 2008-12-02 Ortho-Mcneil Pharmaceutical, Inc. Phosphonic acid compounds as inhibitors of serine proteases
DE102005038141A1 (de) * 2005-08-12 2007-02-15 Grünenthal GmbH Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate
AU2011268073B2 (en) * 2010-06-18 2015-07-16 Takeda Pharmaceutical Company Limited D2 antagonists, methods of synthesis and methods of use
IT201800007580A1 (it) * 2018-07-27 2020-01-27 Maria Cecilia Hospital Spa Composti 1,3,8-triazaspiro e loro uso come medicamenti

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121972A2 (en) * 1983-04-11 1984-10-17 Janssen Pharmaceutica N.V. N-aryl-alpha-amino-carboxamides
EP0121972A3 (en) * 1983-04-11 1987-06-24 Janssen Pharmaceutica N.V. N-aryl-alpha-amino-carboxamides

Also Published As

Publication number Publication date
SE311019B (ja) 1969-05-27
FI46967C (fi) 1973-08-10
FR2986M (fr) 1964-12-07
FR1573808A (ja) 1969-07-11
BE633914A (ja)
GB1043141A (en) 1966-09-21
FR2987M (fr) 1964-12-07
FI46967B (ja) 1973-05-02
FR3043M (fr) 1965-01-04
NO117368B (ja) 1969-08-04
DE1470125C3 (de) 1980-07-10
FR3059M (fr) 1965-01-11
DE1470125A1 (de) 1969-05-08
FR2988M (fr) 1964-12-07
DE1470125B2 (ja) 1979-10-31
DK119880B (da) 1971-03-08

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