FR2986M - Médicament a base de nouveaux 1-aryl-4-oxo-8-aralcoyle-1,3,8-triazaspiro(4,5)décanes, ainsi que leurs sels a action analgésique. - Google Patents

Médicament a base de nouveaux 1-aryl-4-oxo-8-aralcoyle-1,3,8-triazaspiro(4,5)décanes, ainsi que leurs sels a action analgésique.

Info

Publication number
FR2986M
FR2986M FR948241A FR948241A FR2986M FR 2986 M FR2986 M FR 2986M FR 948241 A FR948241 A FR 948241A FR 948241 A FR948241 A FR 948241A FR 2986 M FR2986 M FR 2986M
Authority
FR
France
Prior art keywords
decanes
triazaspiro
aralkyl
oxo
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR948241A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of FR2986M publication Critical patent/FR2986M/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Wire Processing (AREA)
FR948241A 1962-06-22 1963-09-20 Médicament a base de nouveaux 1-aryl-4-oxo-8-aralcoyle-1,3,8-triazaspiro(4,5)décanes, ainsi que leurs sels a action analgésique. Active FR2986M (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20462362A 1962-06-22 1962-06-22
FR939044 1963-06-22

Publications (1)

Publication Number Publication Date
FR2986M true FR2986M (fr) 1964-12-07

Family

ID=22758700

Family Applications (6)

Application Number Title Priority Date Filing Date
FR1573808D Expired FR1573808A (fr) 1962-06-22 1963-06-22
FR948242A Active FR2987M (fr) 1962-06-22 1963-09-20 Médicament a base d'une nouvelle série de 8-[2-(1,4-benzodioxannyl)-méthyl]-1,3,8-triazaspiro (4,5)décanes, ainsi que de leurs sels.
FR948244A Active FR3059M (fr) 1962-06-22 1963-09-20 Médicament pour le traitement des troubles mentaux et cardiovasculaires contenant une nouvelle série de 1-phényl-4-oxo-1,3,8-triazaspiro-[4,5]-décanes ou leurs sels.
FR948241A Active FR2986M (fr) 1962-06-22 1963-09-20 Médicament a base de nouveaux 1-aryl-4-oxo-8-aralcoyle-1,3,8-triazaspiro(4,5)décanes, ainsi que leurs sels a action analgésique.
FR948240A Active FR3043M (fr) 1962-06-22 1963-09-20 Médicament a base d'une nouvelle série de 1-aryl-4-oxo-1,3,8-triazaspiro-(4,5)-décanes, substitués en position 8 ou leurs sels pour le traitement d'affections mentales.
FR948243A Active FR2988M (fr) 1962-06-22 1963-09-20 Médicament pour le traitement d'affections mentales et pour combattre la douleur, a base d'une nouvelle série de 1-phényl-4-oxo-8-(aryl-pentényl)-1,3,8-triazaspiro (4,5) décanes.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
FR1573808D Expired FR1573808A (fr) 1962-06-22 1963-06-22
FR948242A Active FR2987M (fr) 1962-06-22 1963-09-20 Médicament a base d'une nouvelle série de 8-[2-(1,4-benzodioxannyl)-méthyl]-1,3,8-triazaspiro (4,5)décanes, ainsi que de leurs sels.
FR948244A Active FR3059M (fr) 1962-06-22 1963-09-20 Médicament pour le traitement des troubles mentaux et cardiovasculaires contenant une nouvelle série de 1-phényl-4-oxo-1,3,8-triazaspiro-[4,5]-décanes ou leurs sels.

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR948240A Active FR3043M (fr) 1962-06-22 1963-09-20 Médicament a base d'une nouvelle série de 1-aryl-4-oxo-1,3,8-triazaspiro-(4,5)-décanes, substitués en position 8 ou leurs sels pour le traitement d'affections mentales.
FR948243A Active FR2988M (fr) 1962-06-22 1963-09-20 Médicament pour le traitement d'affections mentales et pour combattre la douleur, a base d'une nouvelle série de 1-phényl-4-oxo-8-(aryl-pentényl)-1,3,8-triazaspiro (4,5) décanes.

Country Status (9)

Country Link
BE (1) BE633914A (fr)
CH (1) CH462835A (fr)
DE (1) DE1470125C3 (fr)
DK (1) DK119880B (fr)
FI (1) FI46967C (fr)
FR (6) FR1573808A (fr)
GB (1) GB1043141A (fr)
NO (1) NO117368B (fr)
SE (1) SE311019B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080328A (en) * 1971-07-13 1978-03-21 Sumitomo Chemical Company, Limited N-substituted heterocyclic derivatives and preparation thereof
BE792187A (fr) * 1971-12-03 1973-03-30 Sumitomo Chemical Co Nouveaux derives d'alkylamines
US4066772A (en) * 1975-07-21 1978-01-03 Janssen Pharmaceutica N.V. 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
NZ181256A (en) * 1975-07-21 1978-04-28 Janssen Pharmaceutica Nv 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives
DK139684A (da) * 1983-04-11 1984-10-12 Janssen Pharmaceutica Nv N-aryl-alpha-amino-carboxamider
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5244902A (en) * 1989-08-21 1993-09-14 Beth Israel Hospital Association Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
DE19610397A1 (de) * 1996-03-16 1997-09-18 Krewel Meuselbach Gmbh Gewinnung von Fluspirilen-Suspensionen
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
EP1080091A1 (fr) * 1998-05-18 2001-03-07 Novo Nordisk A/S Nouvelles 1,3,8-triazaspiro[4.5]decanones possedant une affinite elevee pour les sous-types du recepteur opioide
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
DE69923744T2 (de) * 1998-10-23 2006-02-23 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
US7459461B2 (en) 2001-10-19 2008-12-02 Ortho-Mcneil Pharmaceutical, Inc. Phosphonic acid compounds as inhibitors of serine proteases
DE102005038141A1 (de) * 2005-08-12 2007-02-15 Grünenthal GmbH Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate
DK2582701T3 (en) * 2010-06-18 2017-02-06 Altos Therapeutics Llc D2 ANTAGONISTS, SYNTHESIS PROCEDURES AND METHODS OF USE
IT201800007580A1 (it) * 2018-07-27 2020-01-27 Maria Cecilia Hospital Spa Composti 1,3,8-triazaspiro e loro uso come medicamenti

Also Published As

Publication number Publication date
DK119880B (da) 1971-03-08
FR3043M (fr) 1965-01-04
FI46967C (fi) 1973-08-10
SE311019B (fr) 1969-05-27
BE633914A (fr)
FR2987M (fr) 1964-12-07
DE1470125B2 (fr) 1979-10-31
FR3059M (fr) 1965-01-11
DE1470125A1 (de) 1969-05-08
NO117368B (fr) 1969-08-04
DE1470125C3 (de) 1980-07-10
FR2988M (fr) 1964-12-07
GB1043141A (en) 1966-09-21
FR1573808A (fr) 1969-07-11
FI46967B (fr) 1973-05-02
CH462835A (de) 1968-09-30

Similar Documents

Publication Publication Date Title
FR2986M (fr) Médicament a base de nouveaux 1-aryl-4-oxo-8-aralcoyle-1,3,8-triazaspiro(4,5)décanes, ainsi que leurs sels a action analgésique.
FR3548M (fr) Thioxanthenesulfamides substitués, et leurs sels d'addition avec des acides.
FR1275M (fr) Médicament a base de colibacilles vivants.
FR1836M (fr) Médicament a base de dérivés de la β-carboline.
FR3517M (fr) Médicament a base de compositions vitaminées.
FR3516M (fr) Médicament a base de compositions vitaminées.
FR2065M (fr) Médicament a action analgésique a base de phényl-alkylamine.
FR2288M (fr) Médicament analgésique et anti-émétique, a base de 1-phényl-3-(beta-diéthylamino-éthyl)-imidazolidones-(2).
FR2239M (fr) Médicaments a base de dialcoyl-aminoalcoyl-pipéridines.
FR1453M (fr) Médicament analgéique, antithermique, antirhumatismal.
FR1504M (fr) Médicament a base de dérivé du thiaxanthene.
FR1144M (fr) Médicament a base de 1.2-diaryl-3.5-dioxo-pyrazolidines.
FR2893M (fr) Composition pharmaceutique a base de vitamines.
FR2519M (fr) Médicament analgésique.
FR3634M (fr) Médicament utilisable comme stimulant musculaire a base d'acide uridine-5-monophosphorique.
FR1013M (fr) Médicament analgésique, antithermique et antirhumatismal.
FR3571M (fr) Médicaments a base d'acide n-méthyl-amino-butanedioique.
FR3033M (fr) Médicaments a base de sulfapyridines.
FR3565M (fr) Médicament a base d'un nonapeptide-amide cyclique.
FR3494M (fr) Médicament a base de 16α-méthyl-stéroides.
FR1725M (fr) Médicament a base de dérivés de pipéazine.
FR2248M (fr) Médicament a base de nouveaux acides octahydrophénanthroiques.
FR2283M (fr) Médicament analgésique a base de n-propionyl-2-(i-pipéridinoisopropyl)-aminopyridine.
FR1080M (fr) Médicament a base de griséofulvine.
FR1075M (fr) Médicament a base de 4-nitro-3-hydroxy-thiofene-2-carboxylate de méthyle.