CA3174422A1 - Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof - Google Patents

Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof Download PDF

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Publication number
CA3174422A1
CA3174422A1 CA3174422A CA3174422A CA3174422A1 CA 3174422 A1 CA3174422 A1 CA 3174422A1 CA 3174422 A CA3174422 A CA 3174422A CA 3174422 A CA3174422 A CA 3174422A CA 3174422 A1 CA3174422 A1 CA 3174422A1
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CA
Canada
Prior art keywords
compound
cancer
solvate
sdd
prostate cancer
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Pending
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CA3174422A
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English (en)
French (fr)
Inventor
Han-Jie Zhou
Peter Virsik
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ESSA Pharma Inc
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Individual
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Filing date
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Publication of CA3174422A1 publication Critical patent/CA3174422A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3174422A 2020-04-17 2021-04-16 Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof Pending CA3174422A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063011671P 2020-04-17 2020-04-17
US63/011,671 2020-04-17
PCT/US2021/027771 WO2021212032A1 (en) 2020-04-17 2021-04-16 Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof

Publications (1)

Publication Number Publication Date
CA3174422A1 true CA3174422A1 (en) 2021-10-21

Family

ID=78081437

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3174422A Pending CA3174422A1 (en) 2020-04-17 2021-04-16 Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof

Country Status (8)

Country Link
US (6) US20210323931A1 (https=)
EP (1) EP4135675A4 (https=)
JP (2) JP2023522040A (https=)
KR (1) KR20230004498A (https=)
CN (1) CN115916170A (https=)
AU (1) AU2021255723A1 (https=)
CA (1) CA3174422A1 (https=)
WO (1) WO2021212032A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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AU2021255723A1 (en) 2020-04-17 2022-12-08 Essa Pharma, Inc. Solid forms of an N-terminal domain androgen receptor inhibitor and uses thereof
WO2022060969A1 (en) * 2020-09-16 2022-03-24 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
WO2022221661A1 (en) * 2021-04-16 2022-10-20 Essa Pharma, Inc. Pharmaceutical compositions comprising inhibitors of the androgen receptor and uses thereof
WO2023031371A1 (en) * 2021-09-01 2023-03-09 Janssen Pharmaceutica Nv Combination therapies for metastatic castration-resistant prostate cancer
WO2024006207A1 (en) * 2022-06-26 2024-01-04 Essa Pharma Inc. An n-terminal domain androgen receptor inhibitor and uses thereof
CN118706889A (zh) * 2024-05-31 2024-09-27 瀚晖制药有限公司 一种阿帕他胺固体制剂结晶度的检测方法

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Publication number Publication date
US11242324B2 (en) 2022-02-08
US20210332016A1 (en) 2021-10-28
CN115916170A (zh) 2023-04-04
US20220073472A1 (en) 2022-03-10
US11814357B2 (en) 2023-11-14
US20240051926A1 (en) 2024-02-15
JP2023522040A (ja) 2023-05-26
WO2021212032A1 (en) 2021-10-21
JP2024110992A (ja) 2024-08-16
KR20230004498A (ko) 2023-01-06
EP4135675A1 (en) 2023-02-22
US20230104598A1 (en) 2023-04-06
US20220259158A1 (en) 2022-08-18
EP4135675A4 (en) 2024-04-10
US20210323931A1 (en) 2021-10-21
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