CA2983954C - Immunogenic composition - Google Patents
Immunogenic composition Download PDFInfo
- Publication number
- CA2983954C CA2983954C CA2983954A CA2983954A CA2983954C CA 2983954 C CA2983954 C CA 2983954C CA 2983954 A CA2983954 A CA 2983954A CA 2983954 A CA2983954 A CA 2983954A CA 2983954 C CA2983954 C CA 2983954C
- Authority
- CA
- Canada
- Prior art keywords
- protein
- group
- immunogenic composition
- immunogenic
- staphylococcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0421079A GB0421079D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
GB0421081.1 | 2004-09-22 | ||
GB0421078.7 | 2004-09-22 | ||
GB0421082A GB0421082D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
GB0421079.5 | 2004-09-22 | ||
GB0421078A GB0421078D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
GB0421081A GB0421081D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
GB0421082.9 | 2004-09-22 | ||
GB0503143.0 | 2005-02-15 | ||
GB0503143A GB0503143D0 (en) | 2005-02-15 | 2005-02-15 | Immunogenic composition |
CA2580103A CA2580103C (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2580103A Division CA2580103C (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2983954A1 CA2983954A1 (en) | 2006-03-30 |
CA2983954C true CA2983954C (en) | 2019-09-17 |
Family
ID=36000843
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2983954A Expired - Lifetime CA2983954C (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
CA2580103A Expired - Lifetime CA2580103C (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
CA002584290A Abandoned CA2584290A1 (en) | 2004-09-22 | 2005-09-20 | Staphylococcal immunogenic compositions |
CA002580137A Abandoned CA2580137A1 (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2580103A Expired - Lifetime CA2580103C (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
CA002584290A Abandoned CA2584290A1 (en) | 2004-09-22 | 2005-09-20 | Staphylococcal immunogenic compositions |
CA002580137A Abandoned CA2580137A1 (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
Country Status (17)
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA05005045A (es) | 2002-11-12 | 2005-07-01 | Brigham & Womens Hospital | Vacuna de polisacarido para infecciones estafilococicas. |
BRPI0515520A (pt) * | 2004-09-22 | 2008-07-29 | Glaxosmithkline Biolog Sa | composição imunogênica, vacina, métodos de preparar uma vacina e de prevenir ou tratar infecção estafilocócica, e, uso de composição imunogênica |
TW200619228A (en) * | 2004-10-21 | 2006-06-16 | Wyeth Corp | Immunogenic compositions of staphylococcus epidermidis polypeptide antigens |
WO2006059247A2 (en) * | 2004-10-25 | 2006-06-08 | The University Of Western Ontario | VACCINES, COMPOSITIONS AND METHODS BASED ON STAPHYLOCOCCUS AUREUS IRON-REGULATED SURFACE DETERMINANTS IsdA, IsdB, and IsdC |
US20060228368A1 (en) * | 2005-04-07 | 2006-10-12 | Nabi Biopharmaceuticals | Method of protecting against staphylococcal infection |
AU2006263936B2 (en) * | 2005-06-27 | 2010-05-20 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
GB0526038D0 (en) * | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
EP2368570A3 (en) * | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
BRPI0710210A2 (pt) * | 2006-03-30 | 2011-05-24 | Glaxomithkline Biolog S A | composição imunogênica, vacina, métodos para preparar a vacina, e para prevenir ou tratar infecção estafilocócica, uso da composição imunogênica, e, processo para conjugar oligassacarìdeo ou polissacarìdeo capsular |
ES2396453T3 (es) * | 2006-04-24 | 2013-02-21 | Sigma Alimentos, S.A. De C.V. | Método para la detección y cuantificación múltiple y simultánea de patógenos mediante la reacción en cadena de la polimerasa en tiempo real |
GB0610776D0 (en) * | 2006-05-31 | 2006-07-12 | Univ Bath | Novel applications for staphylococcus aureus Sbi protein |
US20180221466A9 (en) * | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
WO2007145689A1 (en) * | 2006-06-12 | 2007-12-21 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
EP2374466B1 (en) * | 2007-05-04 | 2013-08-28 | Krönke, Martin | Protective staphylococcus aureus vaccine based on cell wall-associated proteins |
US8146781B2 (en) * | 2007-08-09 | 2012-04-03 | Huhtamaki, Inc. | Dispenser for viscous condiments |
WO2009023164A2 (en) * | 2007-08-10 | 2009-02-19 | President And Fellows Of Harvard College | Induction of mucosal immunity |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
WO2009029831A1 (en) * | 2007-08-31 | 2009-03-05 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
EP2268618B1 (en) | 2008-03-03 | 2015-05-27 | Novartis AG | Compounds and compositions as tlr activity modulators |
ES2556354T3 (es) * | 2008-03-31 | 2016-01-15 | Otsuka Pharmaceutical Co., Ltd. | Método para la detección de neumococos |
KR20110009158A (ko) * | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
TWI551295B (zh) * | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌(Lawsonia intracellularis)用疫苗 |
CN102159540B (zh) | 2008-07-21 | 2015-08-12 | 布赖汉姆妇女医院 | 与合成的β-1,6葡糖胺寡糖相关的方法和组合物 |
US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
US8318180B2 (en) * | 2008-09-30 | 2012-11-27 | University Of Maryland, Baltimore | Protective vaccine against Staphylococcus aureus biofilms comprising cell wall-associated immunogens |
EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
US8101190B2 (en) * | 2009-03-03 | 2012-01-24 | Ingen Biosciences | Method for diagnosing staphylococcal infections |
WO2011127032A1 (en) | 2010-04-05 | 2011-10-13 | University Of Chicago | Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response |
PT3281947T (pt) | 2009-04-03 | 2020-05-07 | Univ Chicago | Composições e métodos relacionados com variantes da proteína a (spa) |
WO2010144734A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
CN102481352A (zh) * | 2009-06-22 | 2012-05-30 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
WO2011041003A2 (en) * | 2009-06-22 | 2011-04-07 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
WO2012122533A2 (en) * | 2011-03-10 | 2012-09-13 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal proteins isda or isdb |
WO2011017101A2 (en) * | 2009-07-27 | 2011-02-10 | Fina Biosolutions, Llc | Method for producing protein-carbohydrate vaccines reduced in free carbohydrate |
GB0913681D0 (en) * | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
DK2459216T3 (da) | 2009-09-02 | 2013-12-09 | Novartis Ag | Immunogene sammensætninger omfattende tlr-aktivitetsmodulatorer |
WO2011138636A1 (en) | 2009-09-30 | 2011-11-10 | Novartis Ag | Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides |
PL2493498T3 (pl) | 2009-10-30 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Oczyszczanie sacharydów otoczkowych staphylococcus aureus typu 5 i typu 8 |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
CA2781049A1 (en) * | 2009-11-16 | 2011-05-19 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine , Inc. | (poly)-glycerolphosphate-based anti-gram positive bacterial vaccine |
JP5814933B2 (ja) | 2009-12-15 | 2015-11-17 | ノバルティス アーゲー | 免疫増強化合物の均質な懸濁物およびその使用 |
SG10201506165TA (en) | 2009-12-17 | 2015-09-29 | Fina Biosolutions Llc | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
EA023725B1 (ru) | 2010-03-23 | 2016-07-29 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
DK2560738T3 (da) | 2010-04-23 | 2019-08-26 | Serum Inst India Ltd | Simpel fremgangsmåde til samtidig fjernelse af flere urenheder fra dyrkningssupernatanter til ultralave niveauer |
CN102268444B (zh) * | 2010-06-03 | 2015-05-13 | 中国人民解放军军事医学科学院生物工程研究所 | 金黄色葡萄球菌截短SasA蛋白在大肠杆菌中的表达及应用 |
US8821894B2 (en) | 2010-07-02 | 2014-09-02 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
US20130115209A1 (en) * | 2010-07-15 | 2013-05-09 | Tessie B. McNeely | Protective vaccine based on staphylococcus aureus protein sa2412 |
WO2012034067A1 (en) | 2010-09-09 | 2012-03-15 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012065034A1 (en) | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Enolase peptide conjugate vaccines against staphylococcus aureus |
MX350170B (es) * | 2010-12-22 | 2017-08-28 | Wyeth Llc | Composición inmunogénica estable de antígenos de staphylococcus aureus. |
WO2012109167A1 (en) * | 2011-02-08 | 2012-08-16 | Integrated Biotherapeutics, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
CA2826566C (en) * | 2011-02-08 | 2022-09-13 | Medimmune, Llc | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
KR20140071318A (ko) | 2011-06-19 | 2014-06-11 | 뉴욕 유니버시티 | 새로운 항-염증제 및 살균제로서의 류코톡신 e/d |
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US9556281B2 (en) | 2011-08-15 | 2017-01-31 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal protein A |
EP2773370A4 (en) | 2011-10-31 | 2016-09-28 | Merck Sharp & Dohme | PROTECTIVE VACCINE BASED ON THE STAPHYLOCOCCUS AUREUS PROTEIN SA2451 |
CN102698260B (zh) * | 2012-04-20 | 2013-09-25 | 西北农林科技大学 | 预防山羊葡萄球菌乳房炎的亚单位疫苗的制备方法及应用 |
AU2013252883B2 (en) | 2012-04-26 | 2018-05-17 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
EP2841101B1 (en) | 2012-04-26 | 2019-08-07 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
CN111803620A (zh) * | 2012-05-09 | 2020-10-23 | 康特拉费克特公司 | 使用噬菌体溶素的生物膜预防、破坏和处理 |
WO2013184900A2 (en) * | 2012-06-06 | 2013-12-12 | Sanofi Pasteur Biologics, Llc | Immunogenic compositions and related methods |
US9376487B2 (en) | 2012-07-10 | 2016-06-28 | Merck Sharp & Dohme Corp. | Protective vaccine based on Staphylococcus aureus SA2493 protein |
CN102993308B (zh) * | 2012-09-29 | 2014-11-05 | 重庆原伦生物科技有限公司 | 耐甲氧西林金黄色葡萄球菌(mrsa)疫苗重组蛋白抗原hi2及制备方法和应用 |
CN102898511B (zh) * | 2012-10-19 | 2014-05-07 | 重庆原伦生物科技有限公司 | 耐甲氧西林金黄色葡萄球菌重组基因工程疫苗候选抗原i12c制备中的纯化方法 |
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CN103333254A (zh) * | 2013-06-21 | 2013-10-02 | 重庆原伦生物科技有限公司 | 耐甲氧西林金黄色葡萄球菌(mrsa)重组蛋白疫苗i1c的纯化方法 |
BR112016013514B1 (pt) | 2013-12-13 | 2022-04-19 | Stora Enso Oyj (Fi) | Papelão de múltiplas camadas |
CN105483138B (zh) * | 2016-01-22 | 2019-03-26 | 吉林大学 | 一种与致病力相关的灰霉病菌基因BcAtm1及其应用 |
JP7117244B2 (ja) * | 2016-02-12 | 2022-08-12 | ザ・ユニバーシティ・オブ・シカゴ | 黄色ブドウ球菌疾患の間にコアグラーゼ活性を中和する抗体に関連した組成物および方法 |
US11027005B2 (en) * | 2016-10-20 | 2021-06-08 | Km Biologics Co., Ltd. | Method for producing Hib conjugate vaccine using PRP with lowered molecular weight |
CN106692963B (zh) * | 2016-12-28 | 2020-12-22 | 中国人民解放军军事医学科学院生物工程研究所 | 一种用于预防金黄色葡萄球菌感染和破伤风的联合疫苗 |
GB201721576D0 (en) * | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
EP3752182B1 (en) | 2018-02-12 | 2024-05-15 | Inimmune Corporation | Toll-like receptor ligands |
GB201802339D0 (en) | 2018-02-13 | 2018-03-28 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
CN109395072B (zh) * | 2018-10-30 | 2021-11-30 | 中国兽医药品监察所 | 一种腐败梭菌α毒素基因工程疫苗及其生产方法 |
CN110055276A (zh) * | 2019-01-28 | 2019-07-26 | 杨凌职业技术学院 | 一种金葡菌靶向抗菌肽细菌诱导型表达载体及其重组细胞 |
WO2020163512A1 (en) | 2019-02-05 | 2020-08-13 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
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CN112391304B (zh) * | 2019-08-15 | 2023-04-07 | 上海交通大学 | 副血链球菌f278及其用途 |
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