ATE419005T1 - Staphylococcus aureus exopolysaccharid und verfahren - Google Patents

Staphylococcus aureus exopolysaccharid und verfahren

Info

Publication number
ATE419005T1
ATE419005T1 AT02790044T AT02790044T ATE419005T1 AT E419005 T1 ATE419005 T1 AT E419005T1 AT 02790044 T AT02790044 T AT 02790044T AT 02790044 T AT02790044 T AT 02790044T AT E419005 T1 ATE419005 T1 AT E419005T1
Authority
AT
Austria
Prior art keywords
staphylococcus aureus
sae
antigen
aureus exopolysaccharide
immunogenic
Prior art date
Application number
AT02790044T
Other languages
English (en)
Inventor
Joseph JOYCE
James Cook
Chitrananda Abeygunawardana
Karen Grimm
Craig Przysiecki
Robert Hepler
Charlotte Ip
Keith Roper
Qinwei Xu
Kathrin Jansen
Paul Keller
Leslie Cope
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE419005T1 publication Critical patent/ATE419005T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
AT02790044T 2001-12-11 2002-12-06 Staphylococcus aureus exopolysaccharid und verfahren ATE419005T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34675501P 2001-12-11 2001-12-11
US35594102P 2002-02-11 2002-02-11

Publications (1)

Publication Number Publication Date
ATE419005T1 true ATE419005T1 (de) 2009-01-15

Family

ID=26995003

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02790044T ATE419005T1 (de) 2001-12-11 2002-12-06 Staphylococcus aureus exopolysaccharid und verfahren

Country Status (7)

Country Link
US (1) US7157443B2 (de)
EP (1) EP1455817B1 (de)
JP (1) JP2005532415A (de)
AT (1) ATE419005T1 (de)
CA (1) CA2469132A1 (de)
DE (1) DE60230670D1 (de)
WO (1) WO2003053462A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
WO2004043407A2 (en) 2002-11-12 2004-05-27 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
DK1565478T3 (da) 2002-11-12 2017-11-13 Brigham & Womens Hospital Inc Polysaccharidvaccine mod stafylokokinfektioner
DK1651166T3 (da) * 2003-07-24 2010-05-31 Merck Sharp & Dohme Polypeptid til induktion af et beskyttende immunrespons mod staphylococcus aureus
DK1745075T3 (da) 2004-04-21 2013-06-24 Brigham & Womens Hospital Poly-n-acetylglucosamin (pnag/dpnag)-bindende peptider og fremgangsmåder til anvendelse deraf
WO2006032475A2 (en) 2004-09-22 2006-03-30 Glaxosmithkline Biologicals S.A. Staphylococcal immunogenic compositions
ES2503719T3 (es) * 2005-02-11 2014-10-07 Immunogen, Inc. Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
NZ565964A (en) 2005-08-24 2011-11-25 Immunogen Inc Process for preparing maytansinoid antibody conjugates by purifying with tangential flow filtration
CA2647441C (en) 2006-03-30 2021-02-23 Glaxosmithkline Biologicals S.A. Immunogenic composition comprising staphylococcus aureus saccharides
AR060188A1 (es) * 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa Procedimiento de conjugacion
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
CA2697373C (en) 2007-08-27 2019-05-21 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
EP2195466B1 (de) 2007-10-01 2012-10-10 Longhorn Vaccines & Diagnostics, LLC Verfahren zum aufbewahren biologischer proben
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US8609835B2 (en) * 2008-05-28 2013-12-17 Trustees Of Tufts College Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide
RU2532911C2 (ru) 2008-07-21 2014-11-20 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам
EP2341929B1 (de) 2008-10-06 2017-01-25 University Of Chicago Zusammensetzungen und verfahren im zusammenhang mit bakteriellen emp proteinen
HUE026855T2 (en) 2009-04-03 2016-07-28 Univ Chicago Compositions and methods related to protein a (spa) variants
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
LT2437790T (lt) 2009-06-03 2019-06-10 Immunogen, Inc. Konjugavimo būdai
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CA2781166C (en) * 2009-11-30 2018-07-03 Sekisui Medical Co., Ltd. Homogeneous measurement method and measuring reagent
JP2013523818A (ja) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ 免疫反応のエンハンサーとしてのプロテインＡ（ＳｐＡ）抗体に関連する組成物および方法
SG186290A1 (en) 2010-07-02 2013-01-30 Univ Chicago Compositions and methods related to protein a (spa) variants
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
TR201902180T4 (tr) 2011-03-29 2019-03-21 Immunogen Inc Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi
WO2012150603A1 (en) * 2011-05-04 2012-11-08 Serum Institute Of India Ltd. Removal of "polyose type" teichoic acid contaminants from bacterial polyoses
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
CA3207612A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
PL2844275T3 (pl) 2012-04-26 2021-03-08 University Of Chicago Koagulazy gronkowcowe stanowiące antygeny i sposoby ich zastosowania
IN2015DN03202A (de) 2012-10-04 2015-10-02 Immunogen Inc
EP3294448A4 (de) 2015-05-14 2018-12-12 Longhorn Vaccines and Diagnostics, LLC Schnellverfahren zur extraktion von nukleinsäuren aus biologischen proben
WO2020163512A1 (en) 2019-02-05 2020-08-13 The Brigham And Women's Hospital, Inc. Polysaccharide compositions for use in treating filariasis
US12514914B2 (en) 2019-05-14 2026-01-06 The University Of Chicago Methods and compositions comprising Staphylococcus protein a (SpA) variants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
ES2051621B1 (es) 1992-02-04 1995-01-16 Consejo Superior Investigacion Procedimiento de obtencion de vacuna frente a estafilococos.
US5770208A (en) 1996-09-11 1998-06-23 Nabi Staphylococcus aureus B-linked hexosamine antigen
US7252828B2 (en) * 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
EP1096952B1 (de) 1998-07-15 2008-05-21 The Brigham And Women's Hospital, Inc. Polysaccharid-impfstoff gegen staphylokokken infektionen

Also Published As

Publication number Publication date
JP2005532415A (ja) 2005-10-27
US20040259838A1 (en) 2004-12-23
EP1455817A4 (de) 2005-11-30
WO2003053462A2 (en) 2003-07-03
WO2003053462A3 (en) 2003-09-04
DE60230670D1 (de) 2009-02-12
EP1455817A2 (de) 2004-09-15
US7157443B2 (en) 2007-01-02
EP1455817B1 (de) 2008-12-31
CA2469132A1 (en) 2003-07-03

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