CA2964953A1 - Altering gene expression in cart cells and uses thereof - Google Patents

Altering gene expression in cart cells and uses thereof Download PDF

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Publication number
CA2964953A1
CA2964953A1 CA2964953A CA2964953A CA2964953A1 CA 2964953 A1 CA2964953 A1 CA 2964953A1 CA 2964953 A CA2964953 A CA 2964953A CA 2964953 A CA2964953 A CA 2964953A CA 2964953 A1 CA2964953 A1 CA 2964953A1
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cells
cell
tcr
modified
antibody
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English (en)
French (fr)
Inventor
Yangbing Zhao
Jiangtao REN
Xiaojun Liu
Carl H. June
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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Publication of CA2964953A1 publication Critical patent/CA2964953A1/en
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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CA2964953A 2014-10-31 2015-10-15 Altering gene expression in cart cells and uses thereof Pending CA2964953A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462073651P 2014-10-31 2014-10-31
US62/073,651 2014-10-31
PCT/US2015/055799 WO2016069283A1 (en) 2014-10-31 2015-10-15 Altering gene expression in cart cells and uses thereof

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CA2964953A1 true CA2964953A1 (en) 2016-05-06

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ID=55858177

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2964953A Pending CA2964953A1 (en) 2014-10-31 2015-10-15 Altering gene expression in cart cells and uses thereof
CA2964948A Pending CA2964948A1 (en) 2014-10-31 2015-10-15 Altering gene expression in modified t cells and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2964948A Pending CA2964948A1 (en) 2014-10-31 2015-10-15 Altering gene expression in modified t cells and uses thereof

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Country Link
US (7) US20170335331A1 (OSRAM)
EP (4) EP3215168B1 (OSRAM)
JP (5) JP6879910B2 (OSRAM)
KR (5) KR20170075013A (OSRAM)
CN (3) CN107206024B (OSRAM)
AU (4) AU2015339743C1 (OSRAM)
BR (1) BR112017008693A2 (OSRAM)
CA (2) CA2964953A1 (OSRAM)
EA (1) EA201790953A1 (OSRAM)
ES (1) ES2983094T3 (OSRAM)
MX (2) MX2017005698A (OSRAM)
PL (1) PL3215166T3 (OSRAM)
WO (2) WO2016069283A1 (OSRAM)

Cited By (1)

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CN108559760A (zh) * 2018-01-09 2018-09-21 陕西师范大学 基于CRISPR靶向基因组修饰技术建立荧光素酶knock-in细胞系的方法

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WO2013035099A1 (en) 2011-09-08 2013-03-14 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
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US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
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US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
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KR20170075013A (ko) 2014-10-31 2017-06-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Cart 세포에서 유전자 발현의 변경 및 그의 용도
EP4400584A3 (en) 2014-12-03 2024-10-16 Agilent Technologies, Inc. Guide rna with chemical modifications
PL3253865T3 (pl) 2015-02-06 2022-10-10 National University Of Singapore Sposoby wzmacniania skuteczności terapeutycznych komórek odpornościowych
BR112017020750A2 (pt) * 2015-03-27 2018-06-26 Harvard College células t modificadas e métodos de produção e utilização das mesmas
EP3280803B1 (en) 2015-04-06 2021-05-26 The Board of Trustees of the Leland Stanford Junior University Chemically modified guide rnas for crispr/cas-mediated gene regulation
JP2018515139A (ja) 2015-05-08 2018-06-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 万能ドナー幹細胞および関連する方法
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