MX2022005817A - Metodos de fabricacion de linfocitos t-car. - Google Patents

Metodos de fabricacion de linfocitos t-car.

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Publication number
MX2022005817A
MX2022005817A MX2022005817A MX2022005817A MX2022005817A MX 2022005817 A MX2022005817 A MX 2022005817A MX 2022005817 A MX2022005817 A MX 2022005817A MX 2022005817 A MX2022005817 A MX 2022005817A MX 2022005817 A MX2022005817 A MX 2022005817A
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MX
Mexico
Prior art keywords
methods
car
cells
manufacturing
manufacturing car
Prior art date
Application number
MX2022005817A
Other languages
English (en)
Inventor
Hui Yu
Siyuan Tan
Demetrios Kalaitzidis
Julie Carson
Original Assignee
Crispr Therapeutics Ag
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Publication date
Application filed by Crispr Therapeutics Ag filed Critical Crispr Therapeutics Ag
Publication of MX2022005817A publication Critical patent/MX2022005817A/es

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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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Abstract

Algunos aspectos de la presente divulgación, se refieren a métodos para fabricar linfocitos T genomodificados que expresan un receptor quimérico para el antígeno (CAR), que proporcionan varias mejoras con respecto a los métodos de fabricación convencionales, permitiendo así la producción de un suministro fiable de terapias con linfocitos T-CAR clínicamente útiles.
MX2022005817A 2019-11-13 2020-11-13 Metodos de fabricacion de linfocitos t-car. MX2022005817A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962934999P 2019-11-13 2019-11-13
PCT/IB2020/060722 WO2021095012A1 (en) 2019-11-13 2020-11-13 Methods of manufacturing car-t cells

Publications (1)

Publication Number Publication Date
MX2022005817A true MX2022005817A (es) 2022-06-08

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MX2022005817A MX2022005817A (es) 2019-11-13 2020-11-13 Metodos de fabricacion de linfocitos t-car.

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US (1) US20210139935A1 (es)
EP (1) EP4058559A1 (es)
JP (1) JP2023501617A (es)
KR (1) KR20220097985A (es)
CN (1) CN114901808A (es)
AR (1) AR120470A1 (es)
AU (1) AU2020382017A1 (es)
BR (1) BR112022009137A2 (es)
CA (1) CA3158118A1 (es)
CO (1) CO2022006800A2 (es)
IL (1) IL292351A (es)
MX (1) MX2022005817A (es)
TW (1) TW202132560A (es)
WO (1) WO2021095012A1 (es)

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JP2023501617A (ja) 2023-01-18
AR120470A1 (es) 2022-02-16
CN114901808A (zh) 2022-08-12
CO2022006800A2 (es) 2022-06-10
CA3158118A1 (en) 2021-05-20
AU2020382017A1 (en) 2022-05-12
US20210139935A1 (en) 2021-05-13
WO2021095012A1 (en) 2021-05-20
KR20220097985A (ko) 2022-07-08
TW202132560A (zh) 2021-09-01
IL292351A (en) 2022-06-01
BR112022009137A2 (pt) 2022-07-26
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