CA2937738C - Macrocyclic factor xia inhibitors condensed with heterocycles - Google Patents

Macrocyclic factor xia inhibitors condensed with heterocycles Download PDF

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Publication number
CA2937738C
CA2937738C CA2937738A CA2937738A CA2937738C CA 2937738 C CA2937738 C CA 2937738C CA 2937738 A CA2937738 A CA 2937738A CA 2937738 A CA2937738 A CA 2937738A CA 2937738 C CA2937738 C CA 2937738C
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CA
Canada
Prior art keywords
independently
chloro
mmol
chf2
oxo
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Active
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CA2937738A
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English (en)
French (fr)
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CA2937738A1 (en
Inventor
Andrew K. Dilger
James R. Corte
Indawati De Lucca
Tianan Fang
Wu Yang
Yufeng Wang
Kumar Balashanmuga PABBISETTY
William R. Ewing
Yeheng Zhu
Ruth R. Wexler
Donald J.P. Pinto
Michael J. Orwat
Leon M. Ii Smith
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CA2937738A1 publication Critical patent/CA2937738A1/en
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Publication of CA2937738C publication Critical patent/CA2937738C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2937738A 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles Active CA2937738C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461933948P 2014-01-31 2014-01-31
US61/933,948 2014-01-31
PCT/US2015/013647 WO2015116882A1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Publications (2)

Publication Number Publication Date
CA2937738A1 CA2937738A1 (en) 2015-08-06
CA2937738C true CA2937738C (en) 2023-01-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2937738A Active CA2937738C (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Country Status (24)

Country Link
US (3) US20170057961A1 (enExample)
EP (1) EP3099688B1 (enExample)
JP (1) JP6419836B2 (enExample)
CN (1) CN106459051B (enExample)
AR (1) AR099228A1 (enExample)
BR (1) BR112016016741B1 (enExample)
CA (1) CA2937738C (enExample)
CY (1) CY1120534T1 (enExample)
DK (1) DK3099688T3 (enExample)
EA (1) EA032650B1 (enExample)
ES (1) ES2655540T3 (enExample)
HR (1) HRP20172002T1 (enExample)
HU (1) HUE038060T2 (enExample)
LT (1) LT3099688T (enExample)
MX (1) MX2016009385A (enExample)
NO (1) NO2760821T3 (enExample)
PL (1) PL3099688T3 (enExample)
PT (1) PT3099688T (enExample)
RS (1) RS56785B1 (enExample)
SI (1) SI3099688T1 (enExample)
SM (1) SMT201800024T1 (enExample)
TW (1) TWI703144B (enExample)
UY (1) UY35972A (enExample)
WO (1) WO2015116882A1 (enExample)

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NO2760821T3 (enExample) 2014-01-31 2018-03-10
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CN113677682B (zh) * 2019-04-16 2023-05-30 华润生物医药有限公司 作为XIa因子抑制剂的大环衍生物
KR20220031680A (ko) * 2019-07-08 2022-03-11 게리 샤프 이노베이션즈 엘엘씨 고콘트라스트의 소형 편광 기반 콜리메이터
WO2021013209A1 (zh) * 2019-07-23 2021-01-28 南京明德新药研发有限公司 作为XIa因子抑制剂的大环衍生物
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CN115215867B (zh) * 2021-04-21 2023-12-26 上海美悦生物科技发展有限公司 FXIa抑制剂及其药物组合物、制备方法和用途
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US20180222907A1 (en) 2018-08-09
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US20170057961A1 (en) 2017-03-02
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