CA2873404C - Membrane encapsulated nanoparticles and method of use - Google Patents
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- CA2873404C CA2873404C CA2873404A CA2873404A CA2873404C CA 2873404 C CA2873404 C CA 2873404C CA 2873404 A CA2873404 A CA 2873404A CA 2873404 A CA2873404 A CA 2873404A CA 2873404 C CA2873404 C CA 2873404C
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Families Citing this family (176)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| CN107115314B (zh) | 2011-06-02 | 2022-04-29 | 加利福尼亚大学董事会 | 膜包封的纳米颗粒及使用方法 |
| US9541512B2 (en) * | 2011-06-13 | 2017-01-10 | President And Fellows Of Harvard College | Multi-color nanoscale imaging based on nanoparticle cathodoluminescence |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| AU2012352180A1 (en) | 2011-12-16 | 2014-07-31 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| EP2805144A4 (en) * | 2012-01-17 | 2015-09-09 | Scripps Research Inst | PREPARATION OF SAMPLE ARRAYS ON AN ELECTRONIC MICROSCOPE RASTER |
| US9702795B2 (en) * | 2012-01-17 | 2017-07-11 | The Scripps Research Institute | Apparatus and method for producing specimens for electron microscopy |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| KR101993027B1 (ko) * | 2012-04-03 | 2019-09-30 | 레뉴런 리미티드 | 줄기 세포 마이크로입자 |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10954489B2 (en) | 2013-06-04 | 2021-03-23 | The Regents Of The University Of California | Liver-mimetic device and method for simulation of hepatic function using such device |
| WO2015021390A2 (en) * | 2013-08-08 | 2015-02-12 | The Regents Of The University Of California | Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis |
| GB201317887D0 (en) | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| US20170000875A1 (en) | 2013-12-02 | 2017-01-05 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
| WO2015143295A2 (en) * | 2014-03-20 | 2015-09-24 | The Regents Of The University Of California | Hydrogel compositions containing toxin-absorbing or binding nanoparticles and uses thereof |
| ES3009962T3 (en) | 2014-04-23 | 2025-03-31 | Modernatx Inc | Nucleic acid vaccines |
| US10117886B2 (en) | 2014-05-30 | 2018-11-06 | Hao Cheng | Hyaluronidase and a low density second PEG layer on the surface of therapeutic-encapsulated nanoparticles to enhance nanoparticle diffusion and circulation |
| WO2015187502A1 (en) * | 2014-06-02 | 2015-12-10 | Cellics Therapeutics, Inc. | Use of nanoparticles coated with red blood cell membranes to treat hemolytic diseases and disorders |
| US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20170210788A1 (en) | 2014-07-23 | 2017-07-27 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| WO2016028965A1 (en) * | 2014-08-20 | 2016-02-25 | The Regents Of The University Of California | Self-antigen displaying nanoparticles targeting auto-reactive immune factors and uses thereof |
| US10351819B2 (en) | 2014-09-16 | 2019-07-16 | The Regents Of The University Of California | Method for fabrication of microwells for controlled formation of 3-dimensional multicellular-shapes |
| EA035898B1 (ru) | 2014-10-03 | 2020-08-28 | НАНОТИКС, ЭлЭлСи | Композиции и способы для ингибирования биологической активности растворимых биомолекул |
| US10434070B2 (en) | 2015-01-02 | 2019-10-08 | Cellics Therapeutics, Inc. | Use of nanoparticles coated with red blood cell membranes to enable blood transfusion |
| KR101720851B1 (ko) * | 2015-01-29 | 2017-03-28 | 포항공과대학교 산학협력단 | 세포의 지질막에서 유래된 나노소포체 및 이의 용도 |
| EP3265059A4 (en) | 2015-03-03 | 2018-08-29 | Cureport Inc. | Combination liposomal pharmaceutical formulations |
| JP2018507227A (ja) | 2015-03-03 | 2018-03-15 | キュアポート インコーポレイテッド | 二薬搭載リポソーム医薬製剤 |
| WO2016153979A1 (en) | 2015-03-20 | 2016-09-29 | The Regents Of The University Of California | Modulating antibacterial immunity via bacterial membrane-coated nanoparticles |
| US10835493B2 (en) * | 2015-04-20 | 2020-11-17 | Academia Sinica | Platelet-like proteo-microparticles and method of using such in drug delivery |
| WO2016176041A1 (en) * | 2015-04-29 | 2016-11-03 | The Regents Of The University Of California | Detoxification using nanoparticles |
| CN104922671B (zh) * | 2015-06-09 | 2017-12-08 | 深圳先进技术研究院 | 一种吲哚菁绿复合纳米颗粒及其制备方法和应用 |
| JP2018520125A (ja) * | 2015-06-10 | 2018-07-26 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患の処置のためのエキソソームの使用 |
| WO2016205010A1 (en) * | 2015-06-19 | 2016-12-22 | The Regents Of The University Of California | Treating vasculature related diseases or disorders using nanoparticles |
| US11224577B2 (en) | 2015-06-19 | 2022-01-18 | The Regents Of The University Of California | Treating infection by a platelet-targeting microbe using nanoparticles |
| IL297460A (en) * | 2015-06-30 | 2022-12-01 | Nanotics Llc | Compositions and methods related to absorbent particles |
| WO2017008016A1 (en) * | 2015-07-09 | 2017-01-12 | The Board Of Regents Of The University Of Texas System | Nanoparticles containing extracellular matrix for drug delivery |
| MA42502A (fr) | 2015-07-21 | 2018-05-30 | Modernatx Inc | Vaccins contre une maladie infectieuse |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| US10363226B2 (en) * | 2015-08-12 | 2019-07-30 | North Carolina State University | Platelet membrane-coated drug delivery system |
| WO2017030929A1 (en) * | 2015-08-14 | 2017-02-23 | The Johns Hopkins University | Decoy nanoparticles to disrupt cancer cell-stormal cell networks |
| ES2910425T3 (es) | 2015-09-17 | 2022-05-12 | Modernatx Inc | Compuestos y composiciones para la administración intracelular de agentes terapéuticos |
| MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
| PE20181529A1 (es) | 2015-10-22 | 2018-09-26 | Modernatx Inc | Vacunas de acido nucleico para el virus varicela-zoster (vzv) |
| US20180289792A1 (en) | 2015-10-22 | 2018-10-11 | ModernaTX. Inc. | Sexually transmitted disease vaccines |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| CN108699253B (zh) * | 2015-11-18 | 2022-01-25 | 阿瑞萨生物科技有限责任公司 | 用于制备细胞膜或病毒膜以及纳米颗粒的方法和系统 |
| AU2016366978B2 (en) | 2015-12-10 | 2022-07-28 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
| SMT202200252T1 (it) | 2015-12-22 | 2022-07-21 | Modernatx Inc | Composti e composizioni per il rilascio intracellulare di agenti |
| HRP20220525T1 (hr) | 2015-12-23 | 2022-05-27 | Modernatx, Inc. | Postupci uporabe polinukleotida koji kodiraju ligand ox40 |
| US11696959B2 (en) | 2015-12-31 | 2023-07-11 | City Of Hope | Nanoparticle-cell construct with platinum anti-cancer agent |
| WO2017120342A1 (en) * | 2016-01-08 | 2017-07-13 | The Regents Of The University Of California | Cellular or viral membrane coated nanostructures and uses thereof |
| MA43587A (fr) | 2016-01-10 | 2018-11-14 | Modernatx Inc | Arnm thérapeutiques codant pour des anticorps anti-ctla-4 |
| CN105497912A (zh) * | 2016-01-21 | 2016-04-20 | 华东师范大学 | 红细胞膜包裹的酸敏感高分子前药纳米递药系统的制备方法及用途 |
| CN105769818B (zh) * | 2016-03-16 | 2019-03-01 | 华东师范大学 | 用于抗体药物递送的红细胞膜包裹的抗体纳米粒子及制备方法 |
| US20200289666A1 (en) * | 2016-03-28 | 2020-09-17 | The Johns Hopkins University | Biomimetic anisotropic polymeric particles with naturally derived cell membranes for enhanced drug delivery |
| CN106362148B (zh) * | 2016-09-12 | 2019-08-27 | 中南大学 | 一种普鲁士蓝纳米介晶细胞膜包覆修饰方法 |
| CN110035742A (zh) * | 2016-09-29 | 2019-07-19 | 北卡罗来纳州立大学 | 干细胞仿生微粒 |
| EP3534909A4 (en) * | 2016-11-02 | 2020-06-03 | Nanoproteagen | POLYMANANOPARTICLE |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| CN110167587A (zh) | 2016-11-11 | 2019-08-23 | 摩登纳特斯有限公司 | 流感疫苗 |
| CN106620684A (zh) * | 2016-11-18 | 2017-05-10 | 上海交通大学医学院附属新华医院 | 一种泛耐药菌的纳米疫苗及其制备方法 |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| IL299915A (en) | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| US11045540B2 (en) | 2017-03-15 | 2021-06-29 | Modernatx, Inc. | Varicella zoster virus (VZV) vaccine |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| SI3596041T1 (sl) | 2017-03-15 | 2023-02-28 | Modernatx, Inc. | Spojina in sestavki za intracelično dostavljanje terapevtskih sredstev |
| MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
| CA3056133A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| CA3055653A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| EP3609534A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | WIDE SPECTRUM INFLUENZA VIRUS VACCINE |
| CN108653236B (zh) * | 2017-03-31 | 2025-03-25 | 上海惠永药物研究有限公司 | 一种生物膜包载药物纳米晶体的制备方法及其用途 |
| WO2018195526A1 (en) * | 2017-04-21 | 2018-10-25 | Chung Eddie Yocon | Membrane lipid coated nanoparticles and method of use |
| EP3638678B1 (en) | 2017-06-14 | 2025-12-03 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| KR20200044806A (ko) * | 2017-07-28 | 2020-04-29 | 내셔널 유니버시티 오브 싱가포르 | 변형된 유령 세포를 포함하는 생물분자 복합체 |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| US10653767B2 (en) | 2017-09-14 | 2020-05-19 | Modernatx, Inc. | Zika virus MRNA vaccines |
| US20210187018A1 (en) * | 2017-12-07 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Cytobiologics and therapeutic uses thereof |
| CN108066317B (zh) * | 2017-12-19 | 2020-04-03 | 中南大学湘雅三医院 | 纳米药物控释体系的制备方法及其产品与应用 |
| US11353466B2 (en) | 2018-01-18 | 2022-06-07 | Cellics Therapeutics, Inc. | Methods and compositions for quantifying hemoglobin |
| WO2019148101A1 (en) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Rsv rna vaccines |
| CN108042510A (zh) * | 2018-02-11 | 2018-05-18 | 复旦大学附属中山医院 | 一种靶向动脉粥样硬化斑块的血小板膜包被的雷帕霉素仿生纳米颗粒及其用途 |
| US10842755B2 (en) | 2018-03-23 | 2020-11-24 | University Of South Carolina | Nanoparticles for brain targeted drug delivery |
| WO2019198068A1 (en) * | 2018-04-09 | 2019-10-17 | Sabina Glozman | Bioxomes particles, redoxomes, method and composition |
| CN108498805B (zh) * | 2018-04-20 | 2021-04-09 | 中国科学院化学研究所 | 一种利用生物细胞膜提高阳离子共轭聚合物生物相容性的方法 |
| WO2019227091A1 (en) * | 2018-05-25 | 2019-11-28 | The Penn State Research Foundation | Nanoparticle for protein delivery |
| US20230142496A1 (en) * | 2018-06-18 | 2023-05-11 | North Carolina State University | Stem cell biomimetic nanoparticle therapeutic agents and uses thereof |
| CN112955174A (zh) | 2018-07-09 | 2021-06-11 | 旗舰先锋创新V股份有限公司 | 融合剂脂质体组合物和其用途 |
| WO2020023436A1 (en) * | 2018-07-23 | 2020-01-30 | Campbell Robert B | Cell membrane lipid-extracted nanoparticles (clens) for selective targeting, image analysis and cancer therapy |
| US11096899B2 (en) * | 2018-09-07 | 2021-08-24 | Wisconsin Alumni Research Foundation | Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment |
| US12263248B2 (en) | 2018-09-19 | 2025-04-01 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| MA53650A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg et leurs utilisations |
| AU2019345067A1 (en) | 2018-09-19 | 2021-04-08 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| WO2020061457A1 (en) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020080876A1 (ko) * | 2018-10-18 | 2020-04-23 | 고려대학교 세종산학협력단 | 생체 물질 검출 센서 및 그 제조방법 |
| CA3120093A1 (en) | 2018-11-14 | 2020-05-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| US20220031720A1 (en) * | 2018-11-22 | 2022-02-03 | Ramot At Tel-Aviv University Ltd. | Immunogenic compositions containing n-glycol ylneuraminic acid bearing nanoparticles |
| CN111214439B (zh) * | 2018-11-23 | 2023-02-10 | 复旦大学 | 一种具有细菌成孔毒素吸附性能的纳米药物系统及其用途 |
| CA3120860A1 (en) | 2018-11-26 | 2020-06-04 | Arytha Biosciences Llc | Nanoparticles containing cellular membrane and uses thereof |
| AU2019387353A1 (en) * | 2018-11-28 | 2021-07-15 | University Of Delaware | Biomembrane-covered nanoparticles (BioNPs) for delivering active agents to stem cells |
| US10265017B1 (en) * | 2018-12-12 | 2019-04-23 | Lucas J. Myslinski | Device, method and system for implementing a physical area network for cancer immunotherapy |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| KR20220004959A (ko) | 2019-02-27 | 2022-01-12 | 액팀 테라퓨틱스, 인코퍼레이티드 | 종양, 종양-상주 면역 세포, 및 종양 미세환경을 콜로니화하기 위해 조작된 면역자극성 박테리아 |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| EP3938379A4 (en) | 2019-03-15 | 2023-02-22 | ModernaTX, Inc. | Hiv rna vaccines |
| CN113785050B (zh) * | 2019-04-30 | 2025-03-14 | 加利福尼亚大学董事会 | 使用广谱纳米颗粒实现基因组检测 |
| CN111956947A (zh) * | 2019-05-20 | 2020-11-20 | 安行生物技术有限公司 | 向细胞内递送纳米颗粒的方法和装置 |
| US20220323603A1 (en) * | 2019-06-07 | 2022-10-13 | President And Fellows Of Harvard College | Compositions and methods relating to erythrocytes with adhered particles |
| CN110179769A (zh) * | 2019-06-11 | 2019-08-30 | 北京大学深圳医院 | 一种可以诱导病灶部位局部免疫应答的微纳米粒子药物载体 |
| CN110269847A (zh) * | 2019-06-21 | 2019-09-24 | 温州医科大学 | 一种用于中和细菌毒素的仿生纳米材料及其制备方法与应用 |
| CN110302369B (zh) * | 2019-06-28 | 2022-04-29 | 中国人民解放军陆军军医大学 | 以壳聚糖修饰PLGA的大肠杆菌Vo外膜蛋白纳米粒疫苗及其制备方法和应用 |
| WO2021011826A1 (en) * | 2019-07-16 | 2021-01-21 | Coastar Therapeutics Inc. | Process of making membrane lipid coated nanoparticles |
| WO2021046033A1 (en) * | 2019-09-03 | 2021-03-11 | The Regents Of The University Of California | Biomimetic nanoemulsions for oxygen delivery |
| US20220331415A1 (en) * | 2019-09-18 | 2022-10-20 | The Regents Of The University Of California | Immunoactive microparticles and uses thereof |
| CN120423969A (zh) | 2019-09-19 | 2025-08-05 | 摩登纳特斯有限公司 | 用于治疗剂的细胞内递送的支链尾端脂质化合物和组合物 |
| WO2021091582A1 (en) * | 2019-11-08 | 2021-05-14 | The Methodist Hospital | Neurosome/astrosome compositions and methods of use |
| US11771650B2 (en) * | 2019-12-20 | 2023-10-03 | Mcmaster University | Hybrid biological membranes, methods of making and uses thereof |
| CN113041345B (zh) * | 2019-12-26 | 2023-09-01 | 复旦大学 | 一种纳米类毒素疫苗及其用途 |
| CN111111480B (zh) * | 2020-01-09 | 2021-09-14 | 南京工业大学 | 一种唑来磷酸改性纳滤膜及其制备方法 |
| US20230051094A1 (en) * | 2020-01-20 | 2023-02-16 | Arytha Biosciences Llc | Devices containing cellular membrane and uses thereof |
| US20230083448A1 (en) * | 2020-02-07 | 2023-03-16 | The Johns Hopkins University | Compositions of alum nanoparticles for immunomodulation and methods for producing the same |
| WO2021163455A1 (en) * | 2020-02-14 | 2021-08-19 | The Trustees Of Columbia University In The City Of New York | Scalable and facile cell-membrane-coating technology for both positively and negatively charged particles |
| CN111265549B (zh) * | 2020-03-02 | 2022-03-01 | 苏州大学 | 表面pd-l1分子过表达的间充质干细胞膜包被的仿生纳米颗粒及其制备和应用 |
| WO2021194938A1 (en) * | 2020-03-24 | 2021-09-30 | The Regents Of The University Of California | Universal nanosponge for treating respiratory viral infection |
| CN113679829B (zh) * | 2020-05-18 | 2024-01-02 | 北京繁易纳维科技有限公司 | 一种预防癌症术后复发的肿瘤疫苗及其制备方法和应用 |
| CN111603454A (zh) * | 2020-06-08 | 2020-09-01 | 上海交通大学医学院附属第九人民医院 | 一种多重靶向的融合细胞膜修饰的仿生纳米递送系统及其制备方法与应用 |
| WO2022020985A1 (zh) * | 2020-07-27 | 2022-02-03 | 上海市公共卫生临床中心 | 利用呼吸道上皮细胞膜防治呼吸道传染病的方法及应用 |
| CN113041356B (zh) * | 2020-10-28 | 2022-07-22 | 湖南中医药大学 | 血筒素靶向载药体系、制备方法及其应用 |
| WO2022124544A1 (ko) * | 2020-12-07 | 2022-06-16 | 연세대학교 산학협력단 | 면역항암치료제로의 적용을 위한 수지상세포 모방 나노구조체 및 이의 제조방법 |
| US12041939B2 (en) | 2020-12-08 | 2024-07-23 | Cornell University | Enzyme-loaded pollen-mimicking microparticles for organophosphate detoxification of insect pollinators |
| CN112730324B (zh) * | 2020-12-17 | 2022-11-08 | 中山大学 | 基于量子点掺杂的pla纳米线共振散射折射率传感器 |
| CN114762726A (zh) * | 2021-01-15 | 2022-07-19 | 上海交通大学医学院附属仁济医院 | 抗原递呈细胞膜包裹的纳米颗粒及制备方法与应用 |
| CN113209044A (zh) * | 2021-01-29 | 2021-08-06 | 广州医科大学 | 靶向递送HDACIs的仿生纳米颗粒及其制备方法和应用 |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| CN113244189A (zh) * | 2021-02-22 | 2021-08-13 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | 一种基于红细胞膜的超小仿生纳米颗粒制备方法 |
| CA3215391A1 (en) * | 2021-04-13 | 2022-10-20 | Mcmaster University | Functionalized biological membranes with modifying protein molecules, and methods of making and uses thereof |
| CN113181354B (zh) * | 2021-04-25 | 2023-05-26 | 中国农业科学院兰州兽医研究所 | 基于树突状细胞的口蹄疫仿生纳米疫苗及其制备方法和应用 |
| CN113133988B (zh) * | 2021-04-26 | 2023-04-07 | 西南医科大学附属医院 | 一种红细胞膜仿生修饰的肾靶向纳米载药系统、制备方法及应用 |
| CN113197880B (zh) * | 2021-05-07 | 2021-11-12 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种巨噬细胞外泌体膜包被仿生纳米颗粒及其制备方法和应用 |
| CN113633625B (zh) * | 2021-05-19 | 2022-12-09 | 河南大学 | 一种杂膜负载氧化磷酸化抑制剂的纳米药物及其制备方法 |
| CN113398900B (zh) * | 2021-07-14 | 2023-03-31 | 广州汇标检测技术中心 | 一种针对黄曲霉毒素的分子印迹材料及其制备方法和应用 |
| US20230032473A1 (en) * | 2021-07-23 | 2023-02-02 | Wisconsin Alumni Research Foundation | Nad(h) nanoparticles and methods of use |
| CN113893229B (zh) * | 2021-08-06 | 2023-09-05 | 四川省医学科学院·四川省人民医院 | 一种红细胞膜包裹藤黄酸的仿生纳米颗粒、制备方法及其应用 |
| CN113925836A (zh) * | 2021-09-29 | 2022-01-14 | 苏州大学 | 清除rankl的细胞膜包被纳米诱饵、其制备及应用 |
| CN114129536A (zh) * | 2021-12-03 | 2022-03-04 | 深圳市融创金石科技有限公司 | 仿生普鲁士蓝复合材料及其制备方法和应用 |
| CN114470223B (zh) * | 2022-01-13 | 2023-09-29 | 苏州大学 | 清除促炎因子和抑制t细胞活化的细胞膜包被纳米诱饵及其制备方法与应用 |
| WO2023153832A1 (ko) * | 2022-02-14 | 2023-08-17 | 가천대학교 산학협력단 | 병소에 대한 표적능이 강화된 엑토좀-생분해성 고분자 나노입자 복합체 및 그의 제조방법 |
| US20250327041A1 (en) | 2022-02-24 | 2025-10-23 | Io Biotech Aps | Nucleotide delivery of cancer therapy |
| CN114668772B (zh) * | 2022-03-15 | 2024-12-10 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | 负载两性霉素b仿生纳米系统的组合物、制备方法及应用 |
| CA3252492A1 (en) * | 2022-05-09 | 2023-11-16 | Yale University | SKIN CANCER IMMUNOTHERAPY USING MPLA-LOADED HPG NANOPARTICLES |
| CN115068606B (zh) * | 2022-05-23 | 2023-05-16 | 山东大学 | 一种肿瘤靶向纳米制剂、制备方法及在抗肿瘤药物制备中的应用 |
| CN115227671B (zh) * | 2022-07-13 | 2024-01-19 | 中山大学附属第一医院 | 一种药物递送系统及其制备方法和应用 |
| CN115590836B (zh) * | 2022-09-27 | 2024-06-21 | 浙江大学 | 一种提高mRNA疫苗诱导免疫应答能力的脂质纳米颗粒及其应用 |
| CN116139104A (zh) * | 2022-11-29 | 2023-05-23 | 深圳先进技术研究院 | 一种靶向性仿生聚多肽纳米递送载体、纳米核酸递送系统及其制备方法和应用 |
| CN115804762B (zh) * | 2022-12-20 | 2024-05-31 | 浙江大学 | 一种巨噬细胞膜包覆的异位子宫内膜靶向纳米粒、制备方法及应用 |
| CN116270525B (zh) * | 2023-02-22 | 2024-12-13 | 南京华盖制药有限公司 | 一种用于治疗肺部细菌感染性肺炎的可吸入仿生纳米材料及其制备方法和应用 |
| CN118717701A (zh) * | 2023-03-29 | 2024-10-01 | 国家纳米科学中心 | 细菌矿化金属纳米颗粒用于治疗肿瘤 |
| WO2024249782A2 (en) * | 2023-06-02 | 2024-12-05 | The Methodist Hospital | Biomimetic proteolipid nanovesicles for delivery of nucleic acids |
| CN116531344A (zh) * | 2023-06-07 | 2023-08-04 | 重庆医科大学附属儿童医院 | 一种巨噬细胞膜修饰的纳米颗粒及其制备方法和应用 |
| KR20250000043A (ko) * | 2023-06-23 | 2025-01-02 | 한양대학교 산학협력단 | 나노입자, 이의 제조 방법 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| CN116652180B (zh) * | 2023-07-31 | 2023-09-26 | 环保桥(湖南)生态环境工程股份有限公司 | 一种基于零价铁粉的复合颗粒及其制备方法与应用 |
| EP4520345A1 (en) | 2023-09-06 | 2025-03-12 | Myneo Nv | Product |
| EP4556028A1 (en) | 2023-11-14 | 2025-05-21 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut - | Functionalized nanoparticles for viral clearance |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59157033A (ja) * | 1983-02-28 | 1984-09-06 | Hidetoshi Tsuchida | 赤血球ゴ−スト膜フラグメントからなる小胞体の製造方法および小胞体 |
| US4891208A (en) | 1985-04-10 | 1990-01-02 | The Liposome Company, Inc. | Steroidal liposomes |
| ES2062551T3 (es) * | 1989-08-18 | 1994-12-16 | Monsanto Co | Analogos de ferritina. |
| AU646257B2 (en) * | 1990-04-24 | 1994-02-17 | Flustat Pty Limited | Oral vaccine comprising antigen surface-associated with red blood cells |
| US5612034A (en) * | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| US5491219A (en) * | 1993-06-11 | 1996-02-13 | Protein Magnetics | Ferritin with ferrimagnetically ordered ferrite core and method technical field |
| CA2150617C (en) * | 1995-02-07 | 2001-10-30 | Universite Laval | Nanoerythrosome as bioactive agent carrier |
| CA2213906A1 (en) * | 1996-09-23 | 1998-03-23 | Dusica Maysinger | Pharmaceutical composition and method for neuron rescue in ischemic stroke |
| US6395029B1 (en) * | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| GB0007150D0 (en) * | 2000-03-24 | 2000-05-17 | Lamellar Therapeutics Limited | Immunotherapeutic methods and compositions |
| AUPR011700A0 (en) * | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
| FR2839260B1 (fr) * | 2002-05-03 | 2005-02-25 | Inst Nat Sante Rech Med | Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives |
| US20040180094A1 (en) * | 2003-03-11 | 2004-09-16 | Hemolytics, Inc. | Activation agents on the surface of encapsulation vesicles |
| EP2179729B1 (en) | 2003-06-02 | 2016-07-20 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| WO2006033679A2 (en) * | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
| US20070258889A1 (en) * | 2005-11-09 | 2007-11-08 | Montana State University | Novel nanoparticles and use thereof |
| KR101541383B1 (ko) | 2006-03-30 | 2015-08-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| US20070243137A1 (en) * | 2006-04-18 | 2007-10-18 | Nanoprobes, Inc. | Cell and sub-cell methods for imaging and therapy |
| GB2439747A (en) | 2006-07-03 | 2008-01-09 | Uni Degli Studi Di Urbino Carl | Delivery of contrasting agents for magnetic resonance imaging |
| US8465775B2 (en) * | 2006-07-27 | 2013-06-18 | The University Of North Carolina At Chapel Hill | Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells |
| WO2008150276A2 (en) * | 2006-09-26 | 2008-12-11 | The Board Of Regents Of The University Of Texas System | Virus coated nanoparticles and uses thereof |
| RU2345805C1 (ru) | 2007-07-04 | 2009-02-10 | Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" | Способ лазерного фототермолиза серповидно-клеточных эритроцитов |
| US8329161B2 (en) * | 2008-05-01 | 2012-12-11 | National Health Research Institutes | Red blood cell-derived vesicles as a nanoparticle drug delivery system |
| US20110280930A1 (en) | 2008-05-02 | 2011-11-17 | Facundo Batista | Products and methods for stimulating an immune response |
| CN101306196B (zh) | 2008-07-03 | 2011-05-11 | 中国科学院长春应用化学研究所 | 一种生物降解的键合了血红蛋白分子的纳米粒子及制法 |
| ES2605480T3 (es) * | 2008-12-21 | 2017-03-14 | Consiglio Nazionale Delle Ricerche | Sistema de liberación de fármacos a base de eritrocitos, método de preparación y sus usos |
| JP5667180B2 (ja) * | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| CN101735613B (zh) | 2009-12-08 | 2012-09-05 | 四川大学 | 一种聚合物多孔纳米微球及其制备方法 |
| US20130071329A1 (en) * | 2010-03-17 | 2013-03-21 | Board Of Regents Of The University Of Texas System | Theranostic delivery systems with modified surfaces |
| CA2798323A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| GB201011968D0 (en) | 2010-07-16 | 2010-09-01 | Secr Defence | Toxoiding method |
| CN101926984B (zh) * | 2010-08-05 | 2012-09-05 | 中国人民解放军第四军医大学 | 一种人工纳米红细胞的制备方法 |
| CN101934080B (zh) * | 2010-09-08 | 2012-05-23 | 西北大学 | 一种利用静电自组装涂层改善材料血液相容性的方法 |
| EP2701686A4 (en) * | 2011-04-28 | 2014-11-05 | Stc Unm | LIPID BINCHES SUPPORTED ON POROUS NANOPARTICLES (PROTOCELLS) FOR TARGETED ADMINISTRATION, AND METHODS OF USE THEREOF |
| CN107115314B (zh) | 2011-06-02 | 2022-04-29 | 加利福尼亚大学董事会 | 膜包封的纳米颗粒及使用方法 |
| WO2015021390A2 (en) | 2013-08-08 | 2015-02-12 | The Regents Of The University Of California | Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis |
| US20170000875A1 (en) | 2013-12-02 | 2017-01-05 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
| WO2015143295A2 (en) * | 2014-03-20 | 2015-09-24 | The Regents Of The University Of California | Hydrogel compositions containing toxin-absorbing or binding nanoparticles and uses thereof |
| WO2015187502A1 (en) | 2014-06-02 | 2015-12-10 | Cellics Therapeutics, Inc. | Use of nanoparticles coated with red blood cell membranes to treat hemolytic diseases and disorders |
| WO2016028965A1 (en) * | 2014-08-20 | 2016-02-25 | The Regents Of The University Of California | Self-antigen displaying nanoparticles targeting auto-reactive immune factors and uses thereof |
| US10434070B2 (en) | 2015-01-02 | 2019-10-08 | Cellics Therapeutics, Inc. | Use of nanoparticles coated with red blood cell membranes to enable blood transfusion |
| WO2016153979A1 (en) * | 2015-03-20 | 2016-09-29 | The Regents Of The University Of California | Modulating antibacterial immunity via bacterial membrane-coated nanoparticles |
| WO2016176041A1 (en) | 2015-04-29 | 2016-11-03 | The Regents Of The University Of California | Detoxification using nanoparticles |
| WO2016205010A1 (en) | 2015-06-19 | 2016-12-22 | The Regents Of The University Of California | Treating vasculature related diseases or disorders using nanoparticles |
| US11224577B2 (en) | 2015-06-19 | 2022-01-18 | The Regents Of The University Of California | Treating infection by a platelet-targeting microbe using nanoparticles |
| CN108699253B (zh) * | 2015-11-18 | 2022-01-25 | 阿瑞萨生物科技有限责任公司 | 用于制备细胞膜或病毒膜以及纳米颗粒的方法和系统 |
| WO2017120342A1 (en) * | 2016-01-08 | 2017-07-13 | The Regents Of The University Of California | Cellular or viral membrane coated nanostructures and uses thereof |
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