CA2854246A1 - Full length antibody display system for eukaryotic cells and its use - Google Patents

Full length antibody display system for eukaryotic cells and its use Download PDF

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Publication number
CA2854246A1
CA2854246A1 CA2854246A CA2854246A CA2854246A1 CA 2854246 A1 CA2854246 A1 CA 2854246A1 CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A1 CA2854246 A1 CA 2854246A1
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CA
Canada
Prior art keywords
cells
cell
population
antibody
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2854246A
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English (en)
French (fr)
Inventor
Peter Michael HUELSMANN
Hendrik Knoetgen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2854246A1 publication Critical patent/CA2854246A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2854246A 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use Abandoned CA2854246A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11195375 2011-12-22
EP11195375.8 2011-12-22
EP12179029.9 2012-08-02
EP12179029 2012-08-02
PCT/EP2012/076163 WO2013092720A1 (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Publications (1)

Publication Number Publication Date
CA2854246A1 true CA2854246A1 (en) 2013-06-27

Family

ID=47458959

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2854246A Abandoned CA2854246A1 (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Country Status (12)

Country Link
US (1) US20150038354A1 (enExample)
EP (1) EP2794662A1 (enExample)
JP (1) JP2015503907A (enExample)
KR (1) KR20140107295A (enExample)
CN (1) CN104011080B (enExample)
BR (1) BR112014013035A2 (enExample)
CA (1) CA2854246A1 (enExample)
HK (1) HK1200849A1 (enExample)
MX (1) MX2014007262A (enExample)
RU (1) RU2625033C2 (enExample)
SG (1) SG11201403445YA (enExample)
WO (1) WO2013092720A1 (enExample)

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CN119654417A (zh) 2022-06-10 2025-03-18 富士胶片戴奥辛思生物技术英国有限公司 细胞的制备方法、异源多聚体蛋白质的制造方法、双特异性抗体的制造方法、载体组、哺乳动物细胞、cho细胞和细胞池的制备方法
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CN104011080A (zh) 2014-08-27
EP2794662A1 (en) 2014-10-29
US20150038354A1 (en) 2015-02-05
WO2013092720A1 (en) 2013-06-27
JP2015503907A (ja) 2015-02-05
BR112014013035A2 (pt) 2018-10-09
RU2014129736A (ru) 2016-02-20
HK1200849A1 (en) 2015-08-14
SG11201403445YA (en) 2014-07-30
MX2014007262A (es) 2014-08-01
CN104011080B (zh) 2017-10-20
RU2625033C2 (ru) 2017-07-11

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