CA2854246A1 - Full length antibody display system for eukaryotic cells and its use - Google Patents
Full length antibody display system for eukaryotic cells and its use Download PDFInfo
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- CA2854246A1 CA2854246A1 CA2854246A CA2854246A CA2854246A1 CA 2854246 A1 CA2854246 A1 CA 2854246A1 CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A CA2854246 A CA 2854246A CA 2854246 A1 CA2854246 A1 CA 2854246A1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/00—Immunoglobulins specific features
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| GB201407852D0 (en) * | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| CN107207371A (zh) * | 2014-10-20 | 2017-09-26 | 斯克利普斯研究院 | 用于选择结合配偶体的基于邻近度的方法 |
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| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| WO2017136734A1 (en) * | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
| SG10202104509PA (en) * | 2016-03-19 | 2021-06-29 | Exuma Biotech Corp | Methods and compositions for transducing lymphocytes and regulated expansion thereof |
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| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| CN109790214B (zh) | 2016-09-29 | 2022-09-06 | 豪夫迈·罗氏有限公司 | 用于选择产生多肽的细胞的改进方法 |
| EP3526257A2 (en) * | 2016-10-14 | 2019-08-21 | Dana-Farber Cancer Institute, Inc. | Modular tetravalent bispecific antibody platform |
| GB201720351D0 (en) | 2017-12-06 | 2018-01-17 | Iontas Ltd | Selecting for developability in drug discovery |
| CN110872356B (zh) * | 2018-09-03 | 2023-06-13 | 广西慧宝源健康产业有限公司 | 双特异性抗体及其使用方法 |
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| WO2021057726A1 (zh) * | 2019-09-23 | 2021-04-01 | 南开大学 | 利用哺乳动物展示筛选FcγR特异性结合Fc |
| US20230331871A1 (en) * | 2020-03-27 | 2023-10-19 | Ddbio.Co, Ltd., (Shang Hai) | Method for displaying bispecific antibody on surface of mammalian cell and vector |
| CN113150122B (zh) * | 2021-05-19 | 2023-03-17 | 上海儒克生物科技有限公司 | 高通量全兔源单克隆抗体的制备方法 |
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| WO2023238949A1 (ja) | 2022-06-10 | 2023-12-14 | 富士フイルム株式会社 | 細胞の作出方法、ヘテロ多量体タンパク質の製造方法、バイスペシフィック抗体の製造方法、ベクターセット、哺乳動物細胞、ｃｈｏ細胞、及び細胞プールの作出方法 |
| CN119574886A (zh) * | 2024-11-29 | 2025-03-07 | 苏州泓迅生物科技股份有限公司 | 一种基于动物细胞表面展示库的抗体筛选方法及应用 |
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-
2012
- 2012-12-19 EP EP12808373.0A patent/EP2794662A1/en not_active Withdrawn
- 2012-12-19 KR KR1020147016981A patent/KR20140107295A/ko not_active Ceased
- 2012-12-19 RU RU2014129736A patent/RU2625033C2/ru not_active IP Right Cessation
- 2012-12-19 SG SG11201403445YA patent/SG11201403445YA/en unknown
- 2012-12-19 MX MX2014007262A patent/MX2014007262A/es unknown
- 2012-12-19 BR BR112014013035A patent/BR112014013035A2/pt not_active IP Right Cessation
- 2012-12-19 JP JP2014547977A patent/JP2015503907A/ja not_active Ceased
- 2012-12-19 HK HK15101214.1A patent/HK1200849A1/xx unknown
- 2012-12-19 CN CN201280063751.7A patent/CN104011080B/zh not_active Expired - Fee Related
- 2012-12-19 WO PCT/EP2012/076163 patent/WO2013092720A1/en not_active Ceased
- 2012-12-19 CA CA2854246A patent/CA2854246A1/en not_active Abandoned
-
2014
- 2014-06-20 US US14/310,309 patent/US20150038354A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112014013035A2 (pt) | 2018-10-09 |
| WO2013092720A1 (en) | 2013-06-27 |
| US20150038354A1 (en) | 2015-02-05 |
| RU2014129736A (ru) | 2016-02-20 |
| CN104011080A (zh) | 2014-08-27 |
| HK1200849A1 (en) | 2015-08-14 |
| RU2625033C2 (ru) | 2017-07-11 |
| SG11201403445YA (en) | 2014-07-30 |
| CN104011080B (zh) | 2017-10-20 |
| EP2794662A1 (en) | 2014-10-29 |
| MX2014007262A (es) | 2014-08-01 |
| KR20140107295A (ko) | 2014-09-04 |
| JP2015503907A (ja) | 2015-02-05 |
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