MX2014007262A - Sistema de exhibicion de anticuerpos de longitud completa para celulas eucarioticas y su uso. - Google Patents
Sistema de exhibicion de anticuerpos de longitud completa para celulas eucarioticas y su uso.Info
- Publication number
- MX2014007262A MX2014007262A MX2014007262A MX2014007262A MX2014007262A MX 2014007262 A MX2014007262 A MX 2014007262A MX 2014007262 A MX2014007262 A MX 2014007262A MX 2014007262 A MX2014007262 A MX 2014007262A MX 2014007262 A MX2014007262 A MX 2014007262A
- Authority
- MX
- Mexico
- Prior art keywords
- population
- full length
- eukaryotic cells
- length antibody
- membrane
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11195375 | 2011-12-22 | ||
| EP12179029 | 2012-08-02 | ||
| PCT/EP2012/076163 WO2013092720A1 (en) | 2011-12-22 | 2012-12-19 | Full length antibody display system for eukaryotic cells and its use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2014007262A true MX2014007262A (es) | 2014-08-01 |
Family
ID=47458959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014007262A MX2014007262A (es) | 2011-12-22 | 2012-12-19 | Sistema de exhibicion de anticuerpos de longitud completa para celulas eucarioticas y su uso. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150038354A1 (enExample) |
| EP (1) | EP2794662A1 (enExample) |
| JP (1) | JP2015503907A (enExample) |
| KR (1) | KR20140107295A (enExample) |
| CN (1) | CN104011080B (enExample) |
| BR (1) | BR112014013035A2 (enExample) |
| CA (1) | CA2854246A1 (enExample) |
| HK (1) | HK1200849A1 (enExample) |
| MX (1) | MX2014007262A (enExample) |
| RU (1) | RU2625033C2 (enExample) |
| SG (1) | SG11201403445YA (enExample) |
| WO (1) | WO2013092720A1 (enExample) |
Families Citing this family (25)
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| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| GB201407852D0 (en) * | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| CA2964895A1 (en) * | 2014-10-20 | 2016-04-28 | The Scripps Research Institute | Proximity based methods for selection of binding partners |
| CN104818295A (zh) * | 2015-02-03 | 2015-08-05 | 武汉友芝友生物制药有限公司 | 制备和筛选表达双特异性抗体细胞株的方法 |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| EP4414484A3 (en) * | 2016-02-04 | 2025-01-15 | Trianni, Inc. | Enhanced production of immunoglobulins |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| US12590321B2 (en) | 2016-03-19 | 2026-03-31 | Exuma Biotech Corp. | Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| CN108884460B (zh) * | 2016-03-19 | 2023-04-28 | 埃克苏马生物技术公司 | 淋巴细胞转导及其扩增调节的方法与组合物 |
| BR112018071283A2 (pt) | 2016-04-20 | 2019-02-12 | Regeneron Pharma | célula, conjunto de vetores para expressar uma proteína de ligação a antígeno biespecífica em uma célula, conjunto de vetores, método, e, método para produção de uma proteína de ligação a antígeno. |
| EP3472198B1 (en) | 2016-09-29 | 2020-03-04 | H. Hoffnabb-La Roche Ag | Improved method for selecting polypeptide producing cells |
| EP3526257A2 (en) * | 2016-10-14 | 2019-08-21 | Dana-Farber Cancer Institute, Inc. | Modular tetravalent bispecific antibody platform |
| GB201720351D0 (en) | 2017-12-06 | 2018-01-17 | Iontas Ltd | Selecting for developability in drug discovery |
| CN110872356B (zh) * | 2018-09-03 | 2023-06-13 | 广西慧宝源健康产业有限公司 | 双特异性抗体及其使用方法 |
| CN113544275A (zh) * | 2019-03-05 | 2021-10-22 | 信达生物制药(苏州)有限公司 | 展示与分泌目的多肽的酵母展示系统及其用途 |
| CN114829407B (zh) * | 2019-09-23 | 2024-06-21 | 南开大学 | 利用哺乳动物展示筛选FcγR特异性结合Fc |
| MX2022012005A (es) * | 2020-03-27 | 2022-10-21 | Ddbio Co Ltd Shang Hai | Metodo para el despliegue de anticuerpo biespecifico en la superficie de celula de mamifero y vector. |
| EP4306131A4 (en) * | 2021-03-08 | 2025-06-18 | Nanjing GenScript Biotech Co., Ltd. | ANTIBODY DELIVERY USING A DUAL VIRAL VECTOR SYSTEM |
| CN113150122B (zh) * | 2021-05-19 | 2023-03-17 | 上海儒克生物科技有限公司 | 高通量全兔源单克隆抗体的制备方法 |
| EP4453019A1 (en) * | 2021-12-23 | 2024-10-30 | Helsingin Yliopisto | Method for screening a signal peptide for efficient expression and secretion of a heterologous polypeptide in mammalian cells |
| CN119654417A (zh) | 2022-06-10 | 2025-03-18 | 富士胶片戴奥辛思生物技术英国有限公司 | 细胞的制备方法、异源多聚体蛋白质的制造方法、双特异性抗体的制造方法、载体组、哺乳动物细胞、cho细胞和细胞池的制备方法 |
| CN119574886A (zh) * | 2024-11-29 | 2025-03-07 | 苏州泓迅生物科技股份有限公司 | 一种基于动物细胞表面展示库的抗体筛选方法及应用 |
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| ES2424229T3 (es) | 2005-03-18 | 2013-09-30 | Cytos Biotechnology Ag | Proteínas de fusión de alérgenos de gato y utilización de las mismas |
| AU2006304387A1 (en) | 2005-10-14 | 2007-04-26 | Medimmune, Llc | Cell display of antibody libraries |
| EP1957531B1 (en) | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| WO2007064919A2 (en) | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
| US7846724B2 (en) * | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
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| WO2012023053A2 (en) * | 2010-08-16 | 2012-02-23 | Novimmune S.A. | Methods for the generation of multispecific and multivalent antibodies |
| CA2791109C (en) * | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
-
2012
- 2012-12-19 EP EP12808373.0A patent/EP2794662A1/en not_active Withdrawn
- 2012-12-19 BR BR112014013035A patent/BR112014013035A2/pt not_active IP Right Cessation
- 2012-12-19 MX MX2014007262A patent/MX2014007262A/es unknown
- 2012-12-19 RU RU2014129736A patent/RU2625033C2/ru not_active IP Right Cessation
- 2012-12-19 WO PCT/EP2012/076163 patent/WO2013092720A1/en not_active Ceased
- 2012-12-19 SG SG11201403445YA patent/SG11201403445YA/en unknown
- 2012-12-19 CA CA2854246A patent/CA2854246A1/en not_active Abandoned
- 2012-12-19 CN CN201280063751.7A patent/CN104011080B/zh not_active Expired - Fee Related
- 2012-12-19 HK HK15101214.1A patent/HK1200849A1/xx unknown
- 2012-12-19 KR KR1020147016981A patent/KR20140107295A/ko not_active Ceased
- 2012-12-19 JP JP2014547977A patent/JP2015503907A/ja not_active Ceased
-
2014
- 2014-06-20 US US14/310,309 patent/US20150038354A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2854246A1 (en) | 2013-06-27 |
| KR20140107295A (ko) | 2014-09-04 |
| CN104011080A (zh) | 2014-08-27 |
| EP2794662A1 (en) | 2014-10-29 |
| US20150038354A1 (en) | 2015-02-05 |
| WO2013092720A1 (en) | 2013-06-27 |
| JP2015503907A (ja) | 2015-02-05 |
| BR112014013035A2 (pt) | 2018-10-09 |
| RU2014129736A (ru) | 2016-02-20 |
| HK1200849A1 (en) | 2015-08-14 |
| SG11201403445YA (en) | 2014-07-30 |
| CN104011080B (zh) | 2017-10-20 |
| RU2625033C2 (ru) | 2017-07-11 |
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