CA2833009A1 - Insulin-like growth factor-1 receptor inhibitors - Google Patents

Insulin-like growth factor-1 receptor inhibitors Download PDF

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Publication number
CA2833009A1
CA2833009A1 CA2833009A CA2833009A CA2833009A1 CA 2833009 A1 CA2833009 A1 CA 2833009A1 CA 2833009 A CA2833009 A CA 2833009A CA 2833009 A CA2833009 A CA 2833009A CA 2833009 A1 CA2833009 A1 CA 2833009A1
Authority
CA
Canada
Prior art keywords
alkyl
group
chloro
phenoxymethyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2833009A
Other languages
English (en)
French (fr)
Inventor
Sarala Balachandran
Christopher J. Dinsmore
Abhijit Roychowdhury
Rajiv Sharma
Ram Asrey Vishwakarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Enterprises Ltd
Merck Sharp and Dohme LLC
Original Assignee
Piramal Enterprises Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Enterprises Ltd, Merck Sharp and Dohme LLC filed Critical Piramal Enterprises Ltd
Publication of CA2833009A1 publication Critical patent/CA2833009A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2833009A 2011-04-21 2012-04-19 Insulin-like growth factor-1 receptor inhibitors Abandoned CA2833009A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477937P 2011-04-21 2011-04-21
US61/477,937 2011-04-21
PCT/US2012/034188 WO2012145471A1 (en) 2011-04-21 2012-04-19 Insulin-like growth factor-1 receptor inhibitors

Publications (1)

Publication Number Publication Date
CA2833009A1 true CA2833009A1 (en) 2012-10-26

Family

ID=46026953

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2833009A Abandoned CA2833009A1 (en) 2011-04-21 2012-04-19 Insulin-like growth factor-1 receptor inhibitors
CA2831730A Abandoned CA2831730A1 (en) 2011-04-21 2012-04-19 A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2831730A Abandoned CA2831730A1 (en) 2011-04-21 2012-04-19 A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation

Country Status (9)

Country Link
US (3) US20140046059A1 (ref)
EP (2) EP2699568A1 (ref)
JP (1) JP2014514321A (ref)
CN (1) CN103732592A (ref)
AU (2) AU2012245455A1 (ref)
CA (2) CA2833009A1 (ref)
IL (1) IL228810A0 (ref)
IN (1) IN2013MN02170A (ref)
WO (3) WO2012143874A1 (ref)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2699568A1 (en) * 2011-04-21 2014-02-26 Piramal Enterprises Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
WO2014002007A1 (en) * 2012-06-26 2014-01-03 Piramal Enterprises Limited Method of predicting or monitoring response to igf-1r and ir inhibitors using biomarkers
DK2925745T3 (en) 2012-11-29 2018-07-23 Chemocentryx Inc CXCR7 antagonists
WO2014177915A1 (en) 2013-05-01 2014-11-06 Piramal Enterprises Limited Cancer combination therapy using imidazo[4,5-c]quinoline derivatives
CN104098498A (zh) * 2014-07-30 2014-10-15 天津市斯芬克司药物研发有限公司 一种吲唑类化合物及其制备方法
US10375382B2 (en) 2014-09-15 2019-08-06 Dmitry Gorilovsky System comprising multiple digital cameras viewing a large scene
CN105218475A (zh) * 2015-10-15 2016-01-06 湖南华腾制药有限公司 1,2-吗啉盐酸盐的合成方法
US10710975B2 (en) * 2017-12-15 2020-07-14 Inthera Bioscience AG Oxopiperazine derivatives
MX2021006915A (es) 2018-12-12 2021-08-24 Chemocentryx Inc Inhibidores de cxcr7 para el tratamiento de cancer.
CN113149941A (zh) * 2020-01-22 2021-07-23 中国科学院上海药物研究所 醚类化合物及其在防治糖尿病及代谢综合征中的药学用途
WO2025014773A1 (en) 2023-07-07 2025-01-16 Viridian Therapeutics, Inc. Methods of treating chronic thyroid eye disease

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