CA2782015C - Topical ophthalmic compositions and methods for the treatment of macular degeneration - Google Patents

Topical ophthalmic compositions and methods for the treatment of macular degeneration Download PDF

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Publication number
CA2782015C
CA2782015C CA2782015A CA2782015A CA2782015C CA 2782015 C CA2782015 C CA 2782015C CA 2782015 A CA2782015 A CA 2782015A CA 2782015 A CA2782015 A CA 2782015A CA 2782015 C CA2782015 C CA 2782015C
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CA
Canada
Prior art keywords
composition
cyclodextrin
compound
beta
macular degeneration
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CA2782015A
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English (en)
French (fr)
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CA2782015A1 (en
Inventor
Thomas A. Jordan
John Clifford Chabala
Gerald D. Cagle
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Aldeyra Therapeutics Inc
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Aldeyra Therapeutics Inc
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Publication of CA2782015A1 publication Critical patent/CA2782015A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2782015A 2009-12-11 2010-12-09 Topical ophthalmic compositions and methods for the treatment of macular degeneration Active CA2782015C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28574509P 2009-12-11 2009-12-11
US61/285,745 2009-12-11
PCT/US2010/059719 WO2011072141A1 (en) 2009-12-11 2010-12-09 Compositions and methods for the treatment of macular degeneration

Publications (2)

Publication Number Publication Date
CA2782015A1 CA2782015A1 (en) 2011-06-16
CA2782015C true CA2782015C (en) 2020-08-25

Family

ID=44145918

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2782015A Active CA2782015C (en) 2009-12-11 2010-12-09 Topical ophthalmic compositions and methods for the treatment of macular degeneration

Country Status (4)

Country Link
US (4) US9814701B2 (enExample)
JP (4) JP5885670B2 (enExample)
CA (1) CA2782015C (enExample)
WO (1) WO2011072141A1 (enExample)

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MX2015009444A (es) * 2013-01-25 2016-04-15 Aldeyra Therapeutics Inc Trampas novedosas en el tratamiento de la degeneracion macular.
CN118724806A (zh) 2015-08-21 2024-10-01 奥尔德拉医疗公司 氘化化合物和其用途
BR112018069533A2 (pt) 2016-02-28 2019-04-16 Aldeyra Therapeutics, Inc. tratamento de condições alérgicas oculares com ciclodextrinas
EP3454858A4 (en) * 2016-05-09 2020-01-15 Aldeyra Therapeutics, Inc. COMBINATION TREATMENT OF FLAMMABLE CONDITIONS AND DISEASES OF THE EYE
US10414732B2 (en) 2017-03-16 2019-09-17 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
MX2020003425A (es) 2017-10-10 2020-07-29 Aldeyra Therapeutics Inc Tratamiento de trastornos inflamatorios.
JP2021533154A (ja) 2018-08-06 2021-12-02 アルデイラ セラピューティクス, インコーポレイテッド 多形化合物およびその使用
WO2020068986A1 (en) 2018-09-25 2020-04-02 Aldeyra Therapeutics, Inc. Formulations for treatment of dry eye disease
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CN113784954A (zh) 2019-05-02 2021-12-10 奥尔德拉医疗公司 多晶型化合物和其用途
WO2020223717A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
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