CA2608733A1 - Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors - Google Patents
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors Download PDFInfo
- Publication number
- CA2608733A1 CA2608733A1 CA002608733A CA2608733A CA2608733A1 CA 2608733 A1 CA2608733 A1 CA 2608733A1 CA 002608733 A CA002608733 A CA 002608733A CA 2608733 A CA2608733 A CA 2608733A CA 2608733 A1 CA2608733 A1 CA 2608733A1
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- Prior art keywords
- optionally substituted
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- lower alkyl
- fluoro
- nhc
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Landscapes
- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68206305P | 2005-05-17 | 2005-05-17 | |
| US68204205P | 2005-05-17 | 2005-05-17 | |
| US68205105P | 2005-05-17 | 2005-05-17 | |
| US60/682,063 | 2005-05-17 | ||
| US60/682,051 | 2005-05-17 | ||
| US60/682,042 | 2005-05-17 | ||
| US69296005P | 2005-06-22 | 2005-06-22 | |
| US69275005P | 2005-06-22 | 2005-06-22 | |
| US60/692,960 | 2005-06-22 | ||
| US60/692,750 | 2005-06-22 | ||
| PCT/US2006/018726 WO2007013896A2 (en) | 2005-05-17 | 2006-05-16 | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2608733A1 true CA2608733A1 (en) | 2007-02-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002608733A Abandoned CA2608733A1 (en) | 2005-05-17 | 2006-05-16 | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7846941B2 (OSRAM) |
| EP (1) | EP1885723A2 (OSRAM) |
| JP (1) | JP2008545652A (OSRAM) |
| KR (1) | KR20080027775A (OSRAM) |
| AU (1) | AU2006272951A1 (OSRAM) |
| BR (1) | BRPI0610066A2 (OSRAM) |
| CA (1) | CA2608733A1 (OSRAM) |
| CR (1) | CR9591A (OSRAM) |
| EC (1) | ECSP077985A (OSRAM) |
| IL (1) | IL187344A0 (OSRAM) |
| MX (1) | MX2007014377A (OSRAM) |
| NO (1) | NO20075992L (OSRAM) |
| NZ (1) | NZ563444A (OSRAM) |
| WO (1) | WO2007013896A2 (OSRAM) |
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| JP5138938B2 (ja) | 2003-12-19 | 2013-02-06 | プレキシコン インコーポレーテッド | Ｒｅｔ調節剤の開発のための化合物および方法 |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| JP4834553B2 (ja) | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
| CA2608733A1 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| CN102603581B (zh) * | 2005-06-22 | 2015-06-24 | 普莱希科公司 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
| US9006240B2 (en) | 2005-08-02 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
| EP1938842A4 (en) * | 2005-09-01 | 2013-01-09 | Eisai R&D Man Co Ltd | METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION COMPRISING IMPROVED CRASHING CHARACTERISTICS |
| JP2009523812A (ja) * | 2006-01-19 | 2009-06-25 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 融合へテロ二環式キナーゼ阻害剤 |
| AU2007254179B2 (en) * | 2006-05-18 | 2013-03-21 | Pharmacyclics Llc | Intracellular kinase inhibitors |
| RU2448708C3 (ru) | 2006-05-18 | 2017-09-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое средство против рака щитовидной железы |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| BRPI0720695A2 (pt) * | 2006-12-21 | 2014-02-18 | Plexxikon Inc | Compostos e métodos para modulação de cinase, e indicações para estes |
| PE20081581A1 (es) * | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| WO2009073300A1 (en) | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
| US20110003809A1 (en) * | 2008-02-29 | 2011-01-06 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
| EP2265574A1 (en) | 2008-02-29 | 2010-12-29 | Array Biopharma, Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
| WO2009111278A2 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| TW200940539A (en) * | 2008-02-29 | 2009-10-01 | Array Biopharma Inc | RAF inhibitor compounds and methods of use thereof |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN104530052A (zh) * | 2008-06-10 | 2015-04-22 | 普莱希科公司 | 用于激酶调节的5h-吡咯[2,3-b]吡嗪衍生物和其适应症 |
| US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| JP2012509342A (ja) * | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| BRPI0922937A2 (pt) * | 2008-12-05 | 2019-09-24 | Hoffmann La Roche | inibidores de pirrolopirazinil uréia quinase |
| WO2010111527A1 (en) * | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
| AU2010232670B2 (en) | 2009-04-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
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| EP2470532A1 (en) | 2009-08-28 | 2012-07-04 | Array Biopharma, Inc. | 1h-pyrazolo [ 3, 4-b]pyridine compounds for inhibiting raf kinase |
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| RU2012125070A (ru) | 2009-11-18 | 2013-12-27 | Плексксикон, Инк. | Соединения и способы модулирования киназы и показания к их применению |
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-
2006
- 2006-05-16 CA CA002608733A patent/CA2608733A1/en not_active Abandoned
- 2006-05-16 NZ NZ563444A patent/NZ563444A/en not_active IP Right Cessation
- 2006-05-16 EP EP06813186A patent/EP1885723A2/en not_active Withdrawn
- 2006-05-16 AU AU2006272951A patent/AU2006272951A1/en not_active Abandoned
- 2006-05-16 WO PCT/US2006/018726 patent/WO2007013896A2/en not_active Ceased
- 2006-05-16 BR BRPI0610066-0A patent/BRPI0610066A2/pt not_active IP Right Cessation
- 2006-05-16 KR KR1020077029428A patent/KR20080027775A/ko not_active Withdrawn
- 2006-05-16 JP JP2008512402A patent/JP2008545652A/ja active Pending
- 2006-05-16 US US11/435,381 patent/US7846941B2/en active Active
- 2006-05-16 MX MX2007014377A patent/MX2007014377A/es active IP Right Grant
-
2007
- 2007-11-13 IL IL187344A patent/IL187344A0/en unknown
- 2007-11-23 NO NO20075992A patent/NO20075992L/no not_active Application Discontinuation
- 2007-12-07 EC EC2007007985A patent/ECSP077985A/es unknown
- 2007-12-14 CR CR9591A patent/CR9591A/es not_active Application Discontinuation
-
2010
- 2010-12-01 US US12/958,376 patent/US20110166174A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20075992L (no) | 2008-02-13 |
| BRPI0610066A2 (pt) | 2010-05-25 |
| US20110166174A1 (en) | 2011-07-07 |
| MX2007014377A (es) | 2008-02-06 |
| US7846941B2 (en) | 2010-12-07 |
| IL187344A0 (en) | 2008-04-13 |
| NZ563444A (en) | 2011-04-29 |
| ECSP077985A (es) | 2008-01-23 |
| AU2006272951A1 (en) | 2007-02-01 |
| WO2007013896A2 (en) | 2007-02-01 |
| US20070032519A1 (en) | 2007-02-08 |
| WO2007013896A3 (en) | 2007-05-31 |
| JP2008545652A (ja) | 2008-12-18 |
| EP1885723A2 (en) | 2008-02-13 |
| CR9591A (es) | 2008-03-26 |
| KR20080027775A (ko) | 2008-03-28 |
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