CA2529945A1 - Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions - Google Patents

Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions Download PDF

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Publication number
CA2529945A1
CA2529945A1 CA002529945A CA2529945A CA2529945A1 CA 2529945 A1 CA2529945 A1 CA 2529945A1 CA 002529945 A CA002529945 A CA 002529945A CA 2529945 A CA2529945 A CA 2529945A CA 2529945 A1 CA2529945 A1 CA 2529945A1
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CA
Canada
Prior art keywords
polypeptide
domain
antibody
heavy chain
binding
Prior art date
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Abandoned
Application number
CA002529945A
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English (en)
French (fr)
Inventor
Gary R. Braslawsky
Scott Glaser
Tzung-Horng Yang
Jennifer Hopp
Paul Chinn
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Biogen MA Inc
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Individual
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Publication of CA2529945A1 publication Critical patent/CA2529945A1/en
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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  • Oncology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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CA002529945A 2003-06-27 2004-06-28 Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions Abandoned CA2529945A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US48387703P 2003-06-27 2003-06-27
US60/483,877 2003-06-27
US50881003P 2003-10-03 2003-10-03
US60/508,810 2003-10-03
US51535103P 2003-10-28 2003-10-28
US60/515,351 2003-10-28
US51603003P 2003-10-30 2003-10-30
US60/516,030 2003-10-30
PCT/US2004/020944 WO2005000898A2 (en) 2003-06-27 2004-06-28 Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions

Publications (1)

Publication Number Publication Date
CA2529945A1 true CA2529945A1 (en) 2005-01-06

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CA002529945A Abandoned CA2529945A1 (en) 2003-06-27 2004-06-28 Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
CA002530388A Abandoned CA2530388A1 (en) 2003-06-27 2004-06-28 Modified binding molecules comprising connecting peptides

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CA002530388A Abandoned CA2530388A1 (en) 2003-06-27 2004-06-28 Modified binding molecules comprising connecting peptides

Country Status (7)

Country Link
US (3) US7700097B2 (https=)
EP (2) EP1641826A2 (https=)
JP (4) JP5091476B2 (https=)
AU (3) AU2004252171B2 (https=)
CA (2) CA2529945A1 (https=)
NZ (2) NZ544923A (https=)
WO (2) WO2005000898A2 (https=)

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US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
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