CA2490722C - Novel benzimidazole derivatives - Google Patents

Novel benzimidazole derivatives Download PDF

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Publication number
CA2490722C
CA2490722C CA2490722A CA2490722A CA2490722C CA 2490722 C CA2490722 C CA 2490722C CA 2490722 A CA2490722 A CA 2490722A CA 2490722 A CA2490722 A CA 2490722A CA 2490722 C CA2490722 C CA 2490722C
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Canada
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alkyl
halo
alkoxy
hydroxy
group
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Expired - Fee Related
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CA2490722A
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English (en)
French (fr)
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CA2490722A1 (en
Inventor
Norikazu Otake
Minoru Moriya
Yoshio Ogino
Kenji Matsuda
Yoshikazu Nagae
Akio Kanatani
Takehiro Fukami
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MSD KK
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MSD KK
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
CA2490722A 2002-06-28 2003-06-26 Novel benzimidazole derivatives Expired - Fee Related CA2490722C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002190978 2002-06-28
JP2002-190978 2002-06-28
PCT/JP2003/008161 WO2004002986A2 (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives

Publications (2)

Publication Number Publication Date
CA2490722A1 CA2490722A1 (en) 2004-01-08
CA2490722C true CA2490722C (en) 2012-05-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2490722A Expired - Fee Related CA2490722C (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives

Country Status (23)

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US (3) US7105526B2 (US20040054177A1-20040318-C00030.png)
EP (1) EP1517908B1 (US20040054177A1-20040318-C00030.png)
CN (2) CN100427486C (US20040054177A1-20040318-C00030.png)
AR (1) AR040271A1 (US20040054177A1-20040318-C00030.png)
AT (1) ATE506360T1 (US20040054177A1-20040318-C00030.png)
AU (1) AU2003248248B2 (US20040054177A1-20040318-C00030.png)
BR (1) BR0312066A (US20040054177A1-20040318-C00030.png)
CA (1) CA2490722C (US20040054177A1-20040318-C00030.png)
DE (1) DE60336811D1 (US20040054177A1-20040318-C00030.png)
DO (1) DOP2003000662A (US20040054177A1-20040318-C00030.png)
EA (1) EA200500103A1 (US20040054177A1-20040318-C00030.png)
EC (1) ECSP045505A (US20040054177A1-20040318-C00030.png)
HR (1) HRP20041218A2 (US20040054177A1-20040318-C00030.png)
IL (1) IL165810A0 (US20040054177A1-20040318-C00030.png)
IS (1) IS7667A (US20040054177A1-20040318-C00030.png)
MX (1) MXPA04012731A (US20040054177A1-20040318-C00030.png)
NO (1) NO20050184L (US20040054177A1-20040318-C00030.png)
PE (1) PE20040583A1 (US20040054177A1-20040318-C00030.png)
PL (1) PL374693A1 (US20040054177A1-20040318-C00030.png)
RS (1) RS113704A (US20040054177A1-20040318-C00030.png)
TW (1) TW200406411A (US20040054177A1-20040318-C00030.png)
WO (1) WO2004002986A2 (US20040054177A1-20040318-C00030.png)
ZA (1) ZA200409339B (US20040054177A1-20040318-C00030.png)

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