BR0312066A - Novos derivados de benzimidazol - Google Patents
Novos derivados de benzimidazolInfo
- Publication number
- BR0312066A BR0312066A BR0312066-0A BR0312066A BR0312066A BR 0312066 A BR0312066 A BR 0312066A BR 0312066 A BR0312066 A BR 0312066A BR 0312066 A BR0312066 A BR 0312066A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- methane
- disease
- compound
- obesity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
"NOVOS DERIVADOS DE BENZIMIDAZOL"'. A presente invenção se refere a um composto de fórmula (I): (em que A, B, C e D representam independentemente nitrogênio ou metino opcionalmente substituído; E representa nitrogênio, metino ou metino substituído por hidróxi; n é O ou 1; T, U, V e W representam independentemente nitrogênio ou metino opcionalmente substituído; X representa -N(SO~ 2~R^ 4^)-, -N(COR^ 5^)- ou -CO-; Y representa -C(R^ 6^) (R^ 7^)-, -O- ou -N(R8)-, desde que o composto de fórmula (I) quando E for nitrogênio, n for O e X for CO-, e Y for -O-, seja excluído). O composto da invenção e de utilidade como agente destinado ao tratamento de diversas doenças correlacionadas ao neuropeptídeo Y (NPY), por exemplo, distúrbios cardiovasculares, tais como, angina, deficiência cardíaca aguda ou congestiva, infarto do miocárdio, hipertensão, nefropatia, anormalidade de eletrolítica, vasoespasmo, arteriosclerose, etc., distúrbios do sistema nervoso central, tais como, bulimia, depressão, ansiedade, convulsão, epilepsia, demência, dores, alcoolismo, retirada ou exclusão de medicamentos, distúrbios do ritmo circadiano, esquizofrenia, diminuição de memória, distúrbios do sono, diminuição cognitiva, etc., doenças metabólicas, tais como, obesidade, diabetes, anormalidade hormonal, hipercolesterolemia, hiperlipidemia, gota, fígado gorduroso (esteatose hepática), etc., distúrbios genitais ou reprodutores, tais como, infertilidade, trabalho de parto prematuro, disfunção sexual, etc., distúrbios gastrintestinais, distúrbios respiratórios, doenças inflamatórias ou glaucoma, e equivalentes, e também, por exemplo, arteriosclerose, hipogonadismo, hiperandrogenismo, síndrome do ovário policístico, hirsutismo, distúrbio de motilidade gastrintestinal, refluxo gastroesofageal correlacionado à obesidade, obesidade causada por hipoventilação (Síndrome de Pickwickian), apnéia no sono, inflamação, inflamação sistêmica da vasculatura, osteoartrite, resistência à insulina, broncoconstrição, vício em álcool, síndrome metabólica, doença de Alzheimer, hipertrofia cardíaca, hipertrofia ventricular esquerda, hipertrigliceridemia, colesterol de baixo HDL, distúrbios cardiovasculares, tais como, doença coronária cardíaca (CHD), doença cérebro-vascular, derrame, doença vascular periférica, morte súbita, doenças da vesícula biliar, câncer (mama, endometrial, cólon), falta de ar, hiperruricemia, diminuição de fertilidade, dor inferior nas costas e aumento de risco anestésico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002190978 | 2002-06-28 | ||
PCT/JP2003/008161 WO2004002986A2 (en) | 2002-06-28 | 2003-06-26 | Novel benzimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312066A true BR0312066A (pt) | 2005-03-29 |
Family
ID=29996905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0312066-0A BR0312066A (pt) | 2002-06-28 | 2003-06-26 | Novos derivados de benzimidazol |
Country Status (23)
Country | Link |
---|---|
US (3) | US7105526B2 (pt) |
EP (1) | EP1517908B1 (pt) |
CN (2) | CN100560585C (pt) |
AR (1) | AR040271A1 (pt) |
AT (1) | ATE506360T1 (pt) |
AU (1) | AU2003248248B2 (pt) |
BR (1) | BR0312066A (pt) |
CA (1) | CA2490722C (pt) |
DE (1) | DE60336811D1 (pt) |
DO (1) | DOP2003000662A (pt) |
EA (1) | EA200500103A1 (pt) |
EC (1) | ECSP045505A (pt) |
HR (1) | HRP20041218A2 (pt) |
IL (1) | IL165810A0 (pt) |
IS (1) | IS7667A (pt) |
MX (1) | MXPA04012731A (pt) |
NO (1) | NO20050184L (pt) |
PE (1) | PE20040583A1 (pt) |
PL (1) | PL374693A1 (pt) |
RS (1) | RS113704A (pt) |
TW (1) | TW200406411A (pt) |
WO (1) | WO2004002986A2 (pt) |
ZA (1) | ZA200409339B (pt) |
Cited By (1)
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