MXPA02010452A - Analogos de tetrahidroisoquinolina utiles como secretagogos de la hormona del crecimiento. - Google Patents

Analogos de tetrahidroisoquinolina utiles como secretagogos de la hormona del crecimiento.

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Publication number
MXPA02010452A
MXPA02010452A MXPA02010452A MXPA02010452A MXPA02010452A MX PA02010452 A MXPA02010452 A MX PA02010452A MX PA02010452 A MXPA02010452 A MX PA02010452A MX PA02010452 A MXPA02010452 A MX PA02010452A MX PA02010452 A MXPA02010452 A MX PA02010452A
Authority
MX
Mexico
Prior art keywords
growth hormone
hormone secretagogues
tetrahydroisoquinoline
analogs useful
tetrahydroisoquinoline analogs
Prior art date
Application number
MXPA02010452A
Other languages
English (en)
Inventor
Joseph A Tino
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA02010452A publication Critical patent/MXPA02010452A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

Se proporcionan análogos de tetrahidroisoquinolina los cuales son °tiles para estimular la produccion endogena o la liberacion de hormona del crecimiento y para tratar la obesidad, osteoporosis (mejorar la densidad osea) y mejorar la masa muscular y la resistencia muscular. Los análogos de tetrahidroisoquinolina de los mismos tienen la estructura (I) (ver formula) en donde R1, R2, R3, R3a, X1, X2, X3, X4, m y n son como se describen en la presente.
MXPA02010452A 2000-05-11 2001-05-07 Analogos de tetrahidroisoquinolina utiles como secretagogos de la hormona del crecimiento. MXPA02010452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20333500P 2000-05-11 2000-05-11
PCT/US2001/014709 WO2001085695A1 (en) 2000-05-11 2001-05-07 Tetrahydroisoquinoline analogs useful as growth hormone secretagogues

Publications (1)

Publication Number Publication Date
MXPA02010452A true MXPA02010452A (es) 2003-06-06

Family

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MXPA02010452A MXPA02010452A (es) 2000-05-11 2001-05-07 Analogos de tetrahidroisoquinolina utiles como secretagogos de la hormona del crecimiento.

Country Status (15)

Country Link
US (1) US6469024B2 (es)
EP (1) EP1280777B1 (es)
JP (1) JP2004507456A (es)
CN (1) CN1244561C (es)
AR (1) AR028451A1 (es)
AT (1) ATE310728T1 (es)
AU (2) AU2001259592B2 (es)
BR (1) BR0110638A (es)
CA (1) CA2408486A1 (es)
DE (1) DE60115227T2 (es)
ES (1) ES2252230T3 (es)
MX (1) MXPA02010452A (es)
PE (1) PE20011264A1 (es)
UY (1) UY26701A1 (es)
WO (1) WO2001085695A1 (es)

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