CA2486157C - Opioid and opioid-like compounds and uses thereof - Google Patents
Opioid and opioid-like compounds and uses thereof Download PDFInfo
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- CA2486157C CA2486157C CA2486157A CA2486157A CA2486157C CA 2486157 C CA2486157 C CA 2486157C CA 2486157 A CA2486157 A CA 2486157A CA 2486157 A CA2486157 A CA 2486157A CA 2486157 C CA2486157 C CA 2486157C
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- Prior art keywords
- methoxy
- morphinan
- compound
- alkyl
- ring
- Prior art date
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/US2003/015461 WO2003097608A2 (en) | 2002-05-17 | 2003-05-16 | Opioid and opioid-like compounds and uses thereof |
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| JP2521914Y2 (ja) | 1988-12-23 | 1997-01-08 | エヌティエヌ株式会社 | 大型転がり軸受 |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| CA2566445C (en) * | 2004-05-12 | 2016-02-02 | The Government Of The United States As Represented By The Secretary, Department Of Health And Human Services | Methods related to the treatment of neurodegenerative and inflammatory conditions |
| JP4805256B2 (ja) * | 2004-05-14 | 2011-11-02 | グリーン・クロス・コーポレイション | 右旋性モルヒナンの神経保護特性 |
| SA07280459B1 (ar) * | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| EP2357183B1 (en) | 2007-05-01 | 2015-07-01 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| JP5470557B2 (ja) | 2007-07-26 | 2014-04-16 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| RS55769B1 (sr) * | 2007-11-23 | 2017-07-31 | Gruenenthal Gmbh | Kompozicije tapentadola |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| JP5696037B2 (ja) | 2008-05-01 | 2015-04-08 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| RU2531272C2 (ru) | 2008-05-01 | 2014-10-20 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
| EP2291370B1 (en) | 2008-05-01 | 2013-11-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR071719A1 (es) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion |
| WO2010010157A2 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| DK2418211T3 (en) | 2008-09-19 | 2016-06-27 | Concert Pharmaceuticals Inc | DEUTERATED MORPHINAN COMPOUNDS |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| AR078887A1 (es) | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen. |
| BR112012028153A2 (pt) | 2010-05-03 | 2018-08-07 | Tsh Biopharm Corporation Ltd | composição farmacêutica e método para o tratamento de hipertensão |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| US8987293B2 (en) * | 2010-12-23 | 2015-03-24 | Phoenix Pharmalabs, Inc. | Morphinans useful as analgesics |
| WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| CN102731399B (zh) * | 2012-07-06 | 2013-11-06 | 启东东岳药业有限公司 | 高纯度3-甲氧基-9α,13α,14α吗啡喃盐酸盐的制备方法 |
| CN103254131A (zh) * | 2013-04-23 | 2013-08-21 | 苏州谷力生物科技有限公司 | 一种右美沙芬原料药的精制工艺 |
| GB201308440D0 (en) * | 2013-05-10 | 2013-06-19 | Dalgleish Angus | Therapeutic |
| JP6248711B2 (ja) | 2014-03-06 | 2017-12-20 | 株式会社デンソー | 回転電機の固定子 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| CN117137917A (zh) | 2016-04-22 | 2023-12-01 | 景凯生物科技股份有限公司 | 纳美芬、纳曲酮或其衍生物在治疗(非)酒精性脂肪肝炎或非酒精性脂肪性肝病的应用 |
| CN110290792A (zh) * | 2017-01-05 | 2019-09-27 | 景凯生物科技股份有限公司 | 吗啡喃衍生物和其用于治疗自体免疫、发炎或感染相关的障碍的组合物 |
| CN107157998A (zh) * | 2017-05-26 | 2017-09-15 | 张灏 | 右美沙芬的新用途 |
| EP3927709A4 (en) * | 2019-02-19 | 2022-11-02 | Robert J. Barsotti | ORGAN PRESERVATION SOLUTIONS AND PROCESSES |
| CN119977886B (zh) * | 2025-02-13 | 2025-08-22 | 安徽益普克医药科技发展有限公司 | 一种葡萄糖酸喷他佐辛苯甲酸酯及其制备方法与用途 |
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| NL127995C (https=) | 1963-12-20 | Geigy Ag J R | ||
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-
2003
- 2003-05-16 CA CA2486157A patent/CA2486157C/en not_active Expired - Fee Related
- 2003-05-16 AU AU2003234621A patent/AU2003234621A1/en not_active Abandoned
- 2003-05-16 CN CN201310094981.6A patent/CN103405431B/zh not_active Expired - Lifetime
- 2003-05-16 MX MXPA04011327A patent/MXPA04011327A/es not_active Application Discontinuation
- 2003-05-16 EP EP03728964.2A patent/EP1506174B1/en not_active Expired - Lifetime
- 2003-05-16 JP JP2004505341A patent/JP5438250B2/ja not_active Expired - Fee Related
- 2003-05-16 EP EP15186541.7A patent/EP2987788A1/en not_active Withdrawn
- 2003-05-16 CN CN038112396A patent/CN1653050B/zh not_active Expired - Lifetime
- 2003-05-16 WO PCT/US2003/015461 patent/WO2003097608A2/en not_active Ceased
- 2003-11-17 TW TWOPIOIDANA patent/TWI275591B/zh not_active IP Right Cessation
-
2010
- 2010-08-24 AU AU2010212517A patent/AU2010212517A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228118A patent/JP6165592B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-24 JP JP2015089558A patent/JP6193298B2/ja not_active Expired - Lifetime
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2016
- 2016-07-18 HK HK16108452.6A patent/HK1220452A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010212517A1 (en) | 2010-09-16 |
| CN103405431A (zh) | 2013-11-27 |
| AU2003234621A1 (en) | 2003-12-02 |
| CA2486157A1 (en) | 2003-11-27 |
| CN103405431B (zh) | 2016-04-13 |
| JP6165592B2 (ja) | 2017-07-19 |
| TW200427690A (en) | 2004-12-16 |
| WO2003097608A2 (en) | 2003-11-27 |
| CN1653050A (zh) | 2005-08-10 |
| WO2003097608A3 (en) | 2004-03-18 |
| MXPA04011327A (es) | 2005-08-15 |
| HK1220452A1 (en) | 2017-06-09 |
| HK1192711A1 (zh) | 2014-08-29 |
| JP2005530798A (ja) | 2005-10-13 |
| JP2014043452A (ja) | 2014-03-13 |
| JP2015155449A (ja) | 2015-08-27 |
| TWI275591B (en) | 2007-03-11 |
| EP1506174B1 (en) | 2015-09-30 |
| JP5438250B2 (ja) | 2014-03-12 |
| EP1506174A2 (en) | 2005-02-16 |
| EP2987788A1 (en) | 2016-02-24 |
| JP6193298B2 (ja) | 2017-09-06 |
| CN1653050B (zh) | 2013-04-24 |
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