CA2320362A1 - Integrated microfluidic devices - Google Patents

Integrated microfluidic devices Download PDF

Info

Publication number
CA2320362A1
CA2320362A1 CA002320362A CA2320362A CA2320362A1 CA 2320362 A1 CA2320362 A1 CA 2320362A1 CA 002320362 A CA002320362 A CA 002320362A CA 2320362 A CA2320362 A CA 2320362A CA 2320362 A1 CA2320362 A1 CA 2320362A1
Authority
CA
Canada
Prior art keywords
nucleic acid
enrichment
microchannel
sample
flowpath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002320362A
Other languages
English (en)
French (fr)
Inventor
Robert J. Nelson
Herbert H. Hooper
Alan K. Hauser
Sharat Singh
Stephen J. Williams
Alexander P. Sassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2320362A1 publication Critical patent/CA2320362A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002320362A 1998-02-05 1999-02-01 Integrated microfluidic devices Abandoned CA2320362A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/018,918 1998-02-05
US09/018,918 US6074827A (en) 1996-07-30 1998-02-05 Microfluidic method for nucleic acid purification and processing
PCT/US1999/002099 WO1999040174A1 (en) 1998-02-05 1999-02-01 Integrated microfluidic devices

Publications (1)

Publication Number Publication Date
CA2320362A1 true CA2320362A1 (en) 1999-08-12

Family

ID=21790424

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002320362A Abandoned CA2320362A1 (en) 1998-02-05 1999-02-01 Integrated microfluidic devices

Country Status (6)

Country Link
US (4) US6074827A (https=)
EP (1) EP1053298B1 (https=)
JP (1) JP2002502597A (https=)
AU (1) AU758140B2 (https=)
CA (1) CA2320362A1 (https=)
WO (1) WO1999040174A1 (https=)

Families Citing this family (556)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
EP1562035B1 (en) 1997-01-31 2017-01-25 Xy, Llc Optical apparatus and method
WO1998049344A1 (en) 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6979424B2 (en) * 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US20040202579A1 (en) * 1998-05-08 2004-10-14 Anders Larsson Microfluidic device
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US7214544B2 (en) * 1999-03-02 2007-05-08 Qualigen, Inc. Semi-continuous blood separation using magnetic beads
US6334960B1 (en) * 1999-03-11 2002-01-01 Board Of Regents, The University Of Texas System Step and flash imprint lithography
US20010049438A1 (en) * 1999-03-19 2001-12-06 Dix Connie Kim Purification of primer extension products
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
ATE272213T1 (de) * 1999-06-18 2004-08-15 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
FR2795518B1 (fr) * 1999-06-22 2001-12-21 Biomerieux Sa Dispositif de mise en oeuvre d'une carte d'analyse, carte d'analyse et procede les mettant en oeuvre
US6623945B1 (en) 1999-09-16 2003-09-23 Motorola, Inc. System and method for microwave cell lysing of small samples
DE19949551C2 (de) * 1999-10-14 2001-12-13 Agilent Technologies Inc Mikrofluidischer Mikrochip, Energieversorgungseinrichtung und Verfahren zum Betrieb eines mikrofluidischen Mikrochips
US6873087B1 (en) 1999-10-29 2005-03-29 Board Of Regents, The University Of Texas System High precision orientation alignment and gap control stages for imprint lithography processes
US7432634B2 (en) 2000-10-27 2008-10-07 Board Of Regents, University Of Texas System Remote center compliant flexure device
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
WO2001049874A1 (en) * 2000-01-06 2001-07-12 Caliper Technologies Corp. Methods and systems for monitoring intracellular binding reactions
US6927037B2 (en) * 2000-06-22 2005-08-09 Pharmacia Corporation Ion-exchange resin/enzyme activity assay
EP1303792B1 (en) 2000-07-16 2012-10-03 Board Of Regents, The University Of Texas System High-resolution overlay alignement methods and systems for imprint lithography
AU2001277907A1 (en) 2000-07-17 2002-01-30 Board Of Regents, The University Of Texas System Method and system of automatic fluid dispensing for imprint lithography processes
CN1696826A (zh) 2000-08-01 2005-11-16 得克萨斯州大学系统董事会 用对激活光透明的模板在衬底上形成图案的方法及半导体器件
ATE433574T1 (de) * 2000-08-10 2009-06-15 Biomerieux Bv Diagnostischer test auf basis von bewegenden tropfen
EP1390975A2 (en) * 2000-08-21 2004-02-25 The Board Of Regents, The University Of Texas System Flexure based translation stage
FR2813207B1 (fr) * 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
EP1186886A3 (en) * 2000-09-04 2004-01-07 Fuji Photo Film Co., Ltd. Biochemical analyzing method and biochemical analysis apparatus used therefor
KR101031528B1 (ko) 2000-10-12 2011-04-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 실온 저압 마이크로- 및 나노- 임프린트 리소그래피용템플릿
WO2002039083A2 (en) * 2000-11-08 2002-05-16 Science & Technology Corporation @ Unm Fluorescence and fret based assays for biomolecules on beads
US6942778B1 (en) 2000-11-28 2005-09-13 Nanogen, Inc. Microstructure apparatus and method for separating differently charged molecules using an applied electric field
EP1346208A2 (en) * 2000-11-28 2003-09-24 Nanogen, Inc. Microtiter plate format device and methods for separating differently charged molecules using an electric field
FR2817343B1 (fr) * 2000-11-29 2003-05-09 Commissariat Energie Atomique Procede et dispositifs de transport et de concentration d'un analyte present dans un echantillon
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
US7147441B2 (en) * 2000-12-20 2006-12-12 Board Of Trustees Of The University Of Arkansas, N.A. Microfluidics and small volume mixing based on redox magnetohydrodynamics methods
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
EP1354193B1 (en) 2001-01-26 2007-06-06 Biocal Technology, Inc. Optical detection in a multi-channel bio-separation system
CN100533138C (zh) * 2001-01-26 2009-08-26 比奥卡尔技术公司 多通道生物分离盒
JP4797196B2 (ja) * 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
KR100430383B1 (ko) * 2001-05-10 2004-05-04 주식회사 디지탈바이오테크놀러지 혼합 채널 장치의 제작방법 및 패널 상의 튜브 고정방법
GB2375399A (en) * 2001-05-11 2002-11-13 Suisse Electronique Microtech Microfluidic system for the manipulation and concentration of particles suspended in fluid
US6964793B2 (en) 2002-05-16 2005-11-15 Board Of Regents, The University Of Texas System Method for fabricating nanoscale patterns in light curable compositions using an electric field
WO2002097084A1 (en) * 2001-05-25 2002-12-05 Hitachi, Ltd. Apparatus for purifying nucleic acid and method of purifying nucleic acid
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US6825127B2 (en) 2001-07-24 2004-11-30 Zarlink Semiconductor Inc. Micro-fluidic devices
US6977138B2 (en) 2001-07-24 2005-12-20 Massachusetts Institute Of Technology Reactive polymer coatings
WO2003011768A2 (en) * 2001-08-01 2003-02-13 Datascope Investment Corp. Microfluidic device for molecular analysis
EP1444338A4 (en) * 2001-11-15 2007-07-04 Arryx Inc PASTILLE WITH SAMPLES
SE0202399D0 (sv) * 2001-12-11 2002-08-13 Thomas Laurell Device and method useable for integrated sequential separation and enrichment of proteins
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
WO2003062815A1 (en) * 2002-01-18 2003-07-31 Biocal Technology, Inc. Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
US20050023765A1 (en) * 2002-01-31 2005-02-03 Coombs James Howard Bio-safety features for optical analysis disc and disc system including same
US7318902B2 (en) * 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US20030180711A1 (en) * 2002-02-21 2003-09-25 Turner Stephen W. Three dimensional microfluidic device having porous membrane
US7419821B2 (en) * 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
CA2480728A1 (en) 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
US7419784B2 (en) 2002-04-02 2008-09-02 Dubrow Robert S Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
JP2006510871A (ja) * 2002-05-10 2006-03-30 アプレラ コーポレイション 間隙画像領域の減少のための画像化システムおよびその関連方法
US7399449B1 (en) * 2002-05-14 2008-07-15 Sandia Corporation Microfabricated diffusion source
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US20030235787A1 (en) * 2002-06-24 2003-12-25 Watts Michael P.C. Low viscosity high resolution patterning material
US7179079B2 (en) 2002-07-08 2007-02-20 Molecular Imprints, Inc. Conforming template for patterning liquids disposed on substrates
US6932934B2 (en) 2002-07-11 2005-08-23 Molecular Imprints, Inc. Formation of discontinuous films during an imprint lithography process
GB0216077D0 (en) * 2002-07-11 2002-08-21 Univ Cranfield Reconfigurable microfluidic device
US7442336B2 (en) * 2003-08-21 2008-10-28 Molecular Imprints, Inc. Capillary imprinting technique
US7077992B2 (en) 2002-07-11 2006-07-18 Molecular Imprints, Inc. Step and repeat imprint lithography processes
CN1674780A (zh) 2002-08-01 2005-09-28 Xy公司 低压精子分离系统
US6916584B2 (en) 2002-08-01 2005-07-12 Molecular Imprints, Inc. Alignment methods for imprint lithography
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
US7855078B2 (en) 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7071088B2 (en) 2002-08-23 2006-07-04 Molecular Imprints, Inc. Method for fabricating bulbous-shaped vias
US6806543B2 (en) 2002-09-12 2004-10-19 Intel Corporation Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
JP2006501056A (ja) 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
AU2003299541A1 (en) 2002-10-02 2004-05-25 California Institute Of Technology Microfluidic nucleic acid analysis
US20040065252A1 (en) * 2002-10-04 2004-04-08 Sreenivasan Sidlgata V. Method of forming a layer on a substrate to facilitate fabrication of metrology standards
US8349241B2 (en) 2002-10-04 2013-01-08 Molecular Imprints, Inc. Method to arrange features on a substrate to replicate features having minimal dimensional variability
EP1413874A1 (en) * 2002-10-16 2004-04-28 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
EP2233564A3 (en) * 2002-10-30 2012-11-21 Hitachi, Ltd. Cell culture sheet comprising a functional substrate with a group of columnar micro-pillars and its manufacturing method
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
US6929762B2 (en) 2002-11-13 2005-08-16 Molecular Imprints, Inc. Method of reducing pattern distortions during imprint lithography processes
AU2003278682B2 (en) * 2002-11-18 2007-07-19 Agency For Science, Technology And Research Method and system for cell and/or nucleic acid molecules isolation
JPWO2004051231A1 (ja) * 2002-11-29 2006-04-06 日本電気株式会社 分離装置および分離方法
US6871558B2 (en) * 2002-12-12 2005-03-29 Molecular Imprints, Inc. Method for determining characteristics of substrate employing fluid geometries
US7785782B2 (en) * 2002-12-12 2010-08-31 Novartis Vaccines And Diagnostics, Inc. Device and method for in-line blood testing using biochips
AU2003291249A1 (en) * 2002-12-18 2004-07-29 Aclara Biosciences, Inc. Multiplexed immunohistochemical assays using molecular tags
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
GB0303524D0 (en) * 2003-02-15 2003-03-19 Sec Dep For The Home Departmen Improvements in and relating to the handling of dna
WO2004076497A2 (en) * 2003-02-21 2004-09-10 West Virginia University Research Corporation Apparatus and method of using bi-directional capillary electrophoresis
US7655477B1 (en) * 2003-02-26 2010-02-02 Science Applications International Corporation System and method for the separation of analytes
US7452574B2 (en) 2003-02-27 2008-11-18 Molecular Imprints, Inc. Method to reduce adhesion between a polymerizable layer and a substrate employing a fluorine-containing layer
EP1604184A4 (en) * 2003-02-27 2010-10-27 Stephen A Lesko STANDARDIZED EVALUATION OF THERAPEUTIC EFFICIENCY BASED ON CELLULAR BIOMARKERS
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
CN1761865A (zh) * 2003-03-19 2006-04-19 日本电气株式会社 微芯片和提取样品方法、分离样品方法、分析样品方法及回收样品方法
US7122079B2 (en) 2004-02-27 2006-10-17 Molecular Imprints, Inc. Composition for an etching mask comprising a silicon-containing material
US7179396B2 (en) 2003-03-25 2007-02-20 Molecular Imprints, Inc. Positive tone bi-layer imprint lithography method
US7323417B2 (en) * 2004-09-21 2008-01-29 Molecular Imprints, Inc. Method of forming a recessed structure employing a reverse tone process
US7186656B2 (en) * 2004-05-21 2007-03-06 Molecular Imprints, Inc. Method of forming a recessed structure employing a reverse tone process
EP2305173B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Apparatus and methods for providing sorted particles
US7820030B2 (en) * 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7981600B2 (en) * 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
US7396475B2 (en) 2003-04-25 2008-07-08 Molecular Imprints, Inc. Method of forming stepped structures employing imprint lithography
DE602004002888T2 (de) * 2003-05-13 2007-05-31 Becton Dickinson And Co. Vorrichtung und Verfahren zum Sanieren und Entsalzen von biologischen Proben
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
EP1636564A1 (en) * 2003-06-13 2006-03-22 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7157036B2 (en) 2003-06-17 2007-01-02 Molecular Imprints, Inc Method to reduce adhesion between a conformable region and a pattern of a mold
US7390464B2 (en) * 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
WO2004113871A2 (en) * 2003-06-19 2004-12-29 Nagaoka & Co., Ltd. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US20070274863A1 (en) * 2003-07-25 2007-11-29 Horacio Kido Fluidic circuits for sample preparation including bio-discs and methods relating thereto
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
DE10339905B4 (de) * 2003-08-29 2009-04-23 Kist-Europe Forschungsgesellschaft Mbh Implantierbarer Mikrozellprozessor zur Krankheitsbehandlung
AU2004269196B2 (en) * 2003-09-03 2010-03-04 Shmuel Bukshpan Methods and apparatus for rapid crystallization of biomolecules
FR2860006B1 (fr) * 2003-09-24 2006-12-22 Commissariat Energie Atomique Dispositif pour separer et/ou analyser plusieurs cibles moleculaires en solution dans un melange complexe
US7136150B2 (en) 2003-09-25 2006-11-14 Molecular Imprints, Inc. Imprint lithography template having opaque alignment marks
US20050074900A1 (en) * 2003-10-07 2005-04-07 Morgan Nicole Y. Microfluidic flow-through immunoassay for simultaneous detection of multiple proteins in a biological sample
US20060046305A1 (en) * 2003-10-15 2006-03-02 National University Of Singapore Method and apparatus for detecting analyte with filter
CA2563310A1 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007725B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having valve system
US20050106321A1 (en) * 2003-11-14 2005-05-19 Molecular Imprints, Inc. Dispense geometery to achieve high-speed filling and throughput
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
KR20070094669A (ko) * 2003-12-23 2007-09-20 칼리퍼 라이프 사이언시즈, 인크. 분석물 주입 시스템
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7727710B2 (en) * 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US20050156353A1 (en) * 2004-01-15 2005-07-21 Watts Michael P. Method to improve the flow rate of imprinting material
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
US8512959B2 (en) * 2004-02-09 2013-08-20 Northwestern University Monoclonal antibody based biomarker discovery and development platform
US8076386B2 (en) 2004-02-23 2011-12-13 Molecular Imprints, Inc. Materials for imprint lithography
US7906180B2 (en) 2004-02-27 2011-03-15 Molecular Imprints, Inc. Composition for an etching mask comprising a silicon-containing material
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP1729122A1 (en) * 2004-03-01 2006-12-06 Matsushita Electric Industries Co., Ltd. Biosensor, biosensor chip, and biosensor device
WO2005084374A2 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
JP2007537727A (ja) 2004-03-29 2007-12-27 モンサント テクノロジー エルエルシー 受精で用いられる精子分散液
US9863941B2 (en) * 2004-04-01 2018-01-09 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
US20050253307A1 (en) * 2004-05-11 2005-11-17 Molecualr Imprints, Inc. Method of patterning a conductive layer on a substrate
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
EP1768846B1 (en) * 2004-06-03 2010-08-11 Molecular Imprints, Inc. Fluid dispensing and drop-on-demand dispensing for nano-scale manufacturing
US20070228593A1 (en) * 2006-04-03 2007-10-04 Molecular Imprints, Inc. Residual Layer Thickness Measurement and Correction
JP2006006166A (ja) * 2004-06-24 2006-01-12 Univ Of Tokyo 細胞分離装置、及び細胞分離方法
ES2301118T3 (es) * 2004-07-03 2008-06-16 F. Hoffmann-La Roche Ag Interfaz preconcentrada de acoplamiento de electromatografia capilar con electroforesis capilar de zona.
US7799278B2 (en) * 2004-07-06 2010-09-21 Schlumberger Technology Corporation Microfluidic system for chemical analysis
US8262909B2 (en) * 2004-07-06 2012-09-11 Schlumberger Technology Corporation Methods and devices for minimizing membrane fouling for microfluidic separators
US7785526B2 (en) * 2004-07-20 2010-08-31 Molecular Imprints, Inc. Imprint alignment method, system, and template
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
US20060017876A1 (en) * 2004-07-23 2006-01-26 Molecular Imprints, Inc. Displays and method for fabricating displays
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
US7105452B2 (en) * 2004-08-13 2006-09-12 Molecular Imprints, Inc. Method of planarizing a semiconductor substrate with an etching chemistry
US7939131B2 (en) * 2004-08-16 2011-05-10 Molecular Imprints, Inc. Method to provide a layer with uniform etch characteristics
EP2261650A3 (en) 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
US7041604B2 (en) * 2004-09-21 2006-05-09 Molecular Imprints, Inc. Method of patterning surfaces while providing greater control of recess anisotropy
US7241395B2 (en) * 2004-09-21 2007-07-10 Molecular Imprints, Inc. Reverse tone patterning on surfaces having planarity perturbations
US7252777B2 (en) * 2004-09-21 2007-08-07 Molecular Imprints, Inc. Method of forming an in-situ recessed structure
US7205244B2 (en) * 2004-09-21 2007-04-17 Molecular Imprints Patterning substrates employing multi-film layers defining etch-differential interfaces
US7547504B2 (en) * 2004-09-21 2009-06-16 Molecular Imprints, Inc. Pattern reversal employing thick residual layers
US7524672B2 (en) * 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US20060062922A1 (en) * 2004-09-23 2006-03-23 Molecular Imprints, Inc. Polymerization technique to attenuate oxygen inhibition of solidification of liquids and composition therefor
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US7244386B2 (en) * 2004-09-27 2007-07-17 Molecular Imprints, Inc. Method of compensating for a volumetric shrinkage of a material disposed upon a substrate to form a substantially planar structure therefrom
EP1650297B1 (en) * 2004-10-19 2011-04-13 Samsung Electronics Co., Ltd. Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser
AU2005299590B2 (en) 2004-10-27 2010-09-16 Cepheid Closed-system multi-stage nucleic acid amplification reactions
KR100601972B1 (ko) * 2004-11-03 2006-07-18 삼성전자주식회사 레이저와 비드를 이용한 상 분리에 의한 핵산의 정제 장치및 방법
GB2420976B (en) * 2004-11-19 2006-12-20 Zvi Finkelstein Therapeutic implant
KR100601974B1 (ko) * 2004-11-25 2006-07-18 삼성전자주식회사 비드의 상이한 레이저 흡수에 의한 핵산의 정제 장치 및방법
GB0426082D0 (en) * 2004-11-26 2004-12-29 Norchip As A device for carrying out biological assays
WO2006060757A2 (en) * 2004-12-01 2006-06-08 Molecular Imprints, Inc. Eliminating printability of sub-resolution defects in imprint lithography
US7281919B2 (en) 2004-12-07 2007-10-16 Molecular Imprints, Inc. System for controlling a volume of material on a mold
WO2006066216A2 (en) * 2004-12-16 2006-06-22 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20060177535A1 (en) * 2005-02-04 2006-08-10 Molecular Imprints, Inc. Imprint lithography template to facilitate control of liquid movement
US7635263B2 (en) * 2005-01-31 2009-12-22 Molecular Imprints, Inc. Chucking system comprising an array of fluid chambers
US7636999B2 (en) * 2005-01-31 2009-12-29 Molecular Imprints, Inc. Method of retaining a substrate to a wafer chuck
US20060177532A1 (en) * 2005-02-04 2006-08-10 Molecular Imprints, Inc. Imprint lithography method to control extrusion of a liquid from a desired region on a substrate
KR101217549B1 (ko) * 2005-02-03 2013-01-02 삼성전자주식회사 광전 변환 소자를 구비한 핵산 분리 장치, 미세 유체 장치및 그 정제 방법
CA2496294A1 (en) * 2005-02-07 2006-08-07 The University Of British Columbia Apparatus and methods for concentrating and separating particles such as molecules
US7375012B2 (en) 2005-02-28 2008-05-20 Pavel Kornilovich Method of forming multilayer film
US9097723B2 (en) * 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
US7378260B2 (en) * 2005-04-01 2008-05-27 Applera Corporation Products and methods for reducing dye artifacts
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP2008538282A (ja) * 2005-04-05 2008-10-23 セルポイント ダイアグノスティクス， インコーポレイテッド 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法
US9777314B2 (en) * 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
EP1717585B1 (en) * 2005-04-28 2013-01-16 FUJIFILM Corporation Microchip and analysis method using the same
US20070228608A1 (en) * 2006-04-03 2007-10-04 Molecular Imprints, Inc. Preserving Filled Features when Vacuum Wiping
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US20070014699A1 (en) 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
EP2508867A1 (en) * 2005-06-24 2012-10-10 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
DE102005029809B4 (de) * 2005-06-27 2007-04-26 Siemens Ag Vorrichtung und Verfahren zur Aufbereitung einer Probe für eine Analyse und Vorrichtung und Verfahren zur Analyse einer Probe
WO2007005666A2 (en) * 2005-07-01 2007-01-11 Board Of Regents, The University Of Texas System System and method of analyte detection using differential receptors
US20070015191A1 (en) * 2005-07-01 2007-01-18 Promega Corporation Network of buoyant particles for biomolecule purification and use of buoyant particles or network of buoyant particles for biomolecule purification
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) * 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
WO2007011867A2 (en) * 2005-07-15 2007-01-25 Applera Corporation Fluid processing device and method
US7256131B2 (en) * 2005-07-19 2007-08-14 Molecular Imprints, Inc. Method of controlling the critical dimension of structures formed on a substrate
US8808808B2 (en) 2005-07-22 2014-08-19 Molecular Imprints, Inc. Method for imprint lithography utilizing an adhesion primer layer
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7665981B2 (en) * 2005-08-25 2010-02-23 Molecular Imprints, Inc. System to transfer a template transfer body between a motion stage and a docking plate
US20070064384A1 (en) * 2005-08-25 2007-03-22 Molecular Imprints, Inc. Method to transfer a template transfer body between a motion stage and a docking plate
US20070074635A1 (en) * 2005-08-25 2007-04-05 Molecular Imprints, Inc. System to couple a body and a docking plate
EP1931800A4 (en) * 2005-09-15 2011-06-15 Artemis Health Inc SYSTEMS AND METHOD FOR ENRICHING ANALYTES
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US7316554B2 (en) 2005-09-21 2008-01-08 Molecular Imprints, Inc. System to control an atmosphere between a body and a substrate
US20070077763A1 (en) * 2005-09-30 2007-04-05 Molecular Imprints, Inc. Deposition technique to planarize a multi-layer structure
US7611834B2 (en) * 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
WO2007041619A2 (en) * 2005-09-30 2007-04-12 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
DE102005053463A1 (de) * 2005-11-06 2007-05-10 Aj Innuscreen Gmbh Vorrichtung und Verfahren zur automatisierten Isolierung und Aufreinigung von Nukleinsäuren aus beliebigen komplexen Ausgangsmaterialien
EP1951860A4 (en) * 2005-11-21 2012-06-06 Life Technologies Corp PORTABLE PREPARATION, ANALYSIS AND DETECTION APPARATUS FOR THE TREATMENT OF NUCLEIC ACIDS
US7803308B2 (en) 2005-12-01 2010-09-28 Molecular Imprints, Inc. Technique for separating a mold from solidified imprinting material
US7906058B2 (en) * 2005-12-01 2011-03-15 Molecular Imprints, Inc. Bifurcated contact printing technique
US20100190265A1 (en) * 2005-12-02 2010-07-29 Technical University Of Denmark Fluidics device for assay
US7670530B2 (en) 2006-01-20 2010-03-02 Molecular Imprints, Inc. Patterning substrates employing multiple chucks
MY144847A (en) 2005-12-08 2011-11-30 Molecular Imprints Inc Method and system for double-sided patterning of substrates
US8030034B2 (en) * 2005-12-09 2011-10-04 Promega Corporation Nucleic acid purification with a binding matrix
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
WO2007092713A2 (en) * 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
JP5063616B2 (ja) * 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US7909928B2 (en) 2006-03-24 2011-03-22 The Regents Of The University Of Michigan Reactive coatings for regioselective surface modification
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
JP5306989B2 (ja) 2006-04-03 2013-10-02 モレキュラー・インプリンツ・インコーポレーテッド 複数のフィールド及びアライメント・マークを有する基板を同時にパターニングする方法
US7802978B2 (en) 2006-04-03 2010-09-28 Molecular Imprints, Inc. Imprinting of partial fields at the edge of the wafer
US8142850B2 (en) 2006-04-03 2012-03-27 Molecular Imprints, Inc. Patterning a plurality of fields on a substrate to compensate for differing evaporation times
US8850980B2 (en) 2006-04-03 2014-10-07 Canon Nanotechnologies, Inc. Tessellated patterns in imprint lithography
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7547398B2 (en) * 2006-04-18 2009-06-16 Molecular Imprints, Inc. Self-aligned process for fabricating imprint templates containing variously etched features
US8012395B2 (en) 2006-04-18 2011-09-06 Molecular Imprints, Inc. Template having alignment marks formed of contrast material
EP2016415B1 (en) 2006-04-21 2013-08-14 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods for drug discovery, including discovery of anticancer and antiviral agents
US7854867B2 (en) 2006-04-21 2010-12-21 Molecular Imprints, Inc. Method for detecting a particle in a nanoimprint lithography system
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US7947148B2 (en) 2006-06-01 2011-05-24 The Regents Of The University Of Michigan Dry adhesion bonding
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20080090239A1 (en) * 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
GB0617035D0 (en) 2006-08-30 2006-10-11 Inverness Medical Switzerland Fluidic indicator device
WO2008052138A2 (en) 2006-10-25 2008-05-02 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated dna analysis system using same
WO2008052136A2 (en) 2006-10-25 2008-05-02 Proteus Biomedical, Inc. Controlled activation ingestible identifier
WO2008058204A1 (en) * 2006-11-07 2008-05-15 University Of Virginia Patent Foundation Dna purification in a multi-stage, multi-phase microchip
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008083687A1 (en) * 2007-01-10 2008-07-17 Scandinavian Micro Biodevices Aps A microfluidic device and a microfluidic system and a method of performing a test
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
TWI368082B (en) * 2007-03-15 2012-07-11 Au Optronics Corp Display panel
US7799656B2 (en) 2007-03-15 2010-09-21 Dalsa Semiconductor Inc. Microchannels for BioMEMS devices
US8399047B2 (en) 2007-03-22 2013-03-19 The Regents Of The Univeristy Of Michigan Multifunctional CVD coatings
WO2008118831A2 (en) * 2007-03-23 2008-10-02 Advanced Liquid Logic, Inc. Droplet actuator loading and target concentration
US20100151465A1 (en) 2008-03-27 2010-06-17 Jingyue Ju Selective Capture and Release of Analytes
WO2008131039A2 (en) * 2007-04-16 2008-10-30 Board Of Regents, The University Of Texas System Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
US20100129878A1 (en) * 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
EP2152417B1 (en) * 2007-05-04 2018-07-11 Opko Diagnostics, LLC Device and method for analyses in microfluidic systems
US20080296158A1 (en) 2007-05-31 2008-12-04 Sharp Kabushiki Kaisha Device for electrophoresis, device for transfer, device for electrophoresis and transfer, chip for electrophoresis and transfer, and method for electrophoresis, method for transfer, and method for electrophoresis and transfer
GB0710957D0 (en) * 2007-06-07 2007-07-18 Norchip As A device for carrying out cell lysis and nucleic acid extraction
CA2754884C (en) 2007-06-21 2013-04-30 Gen-Probe Incorporated Methods of concentrating an analyte
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US7959861B2 (en) * 2007-09-19 2011-06-14 Stc.Unm Integrated affinity microcolumns and affinity capillary electrophoresis
US20090130746A1 (en) * 2007-10-25 2009-05-21 Canon U.S. Life Sciences, Inc. Microchannel surface coating
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US20090111193A1 (en) 2007-10-31 2009-04-30 Cooney Christopher G Sample preparation device
US7759112B2 (en) * 2007-10-31 2010-07-20 Akonni Biosystems, Inc. Apparatus, system, and method for purifying nucleic acids
US10125388B2 (en) 2007-10-31 2018-11-13 Akonni Biosystems, Inc. Integrated sample processing system
US8049183B1 (en) * 2007-11-09 2011-11-01 Carnegie Mellon University Apparatuses and methods for control and self-assembly of particles into adaptable monolayers
US9409166B2 (en) * 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
US8815576B2 (en) * 2007-12-27 2014-08-26 Lawrence Livermore National Security, Llc. Chip-based sequencing nucleic acids
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
WO2009124068A1 (en) * 2008-03-31 2009-10-08 Accelr8 Technology Corporation Iterative screening and subtractive process for marker discovery
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
US9879360B2 (en) * 2008-06-20 2018-01-30 International Business Machines Corporation Microfluidic selection of library elements
US20090318303A1 (en) * 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
JP5795255B2 (ja) * 2008-07-18 2015-10-14 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 微小流体ｄｎａ試料調製のための方法およびシステム
JP4722977B2 (ja) * 2008-08-27 2011-07-13 シャープ株式会社 検出器具、分析装置、検出方法および検出器具の制御方法
US20100068735A1 (en) * 2008-09-12 2010-03-18 Samsung Electronics Co., Ltd. Microfluidic device including unit for evaluating capture material and method of evaluating capture material
HUE031848T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
US20240342709A1 (en) * 2008-10-22 2024-10-17 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8546128B2 (en) 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
CN104195227B (zh) 2008-11-07 2017-04-12 适应生物技术公司 通过序列分析监测状况的方法
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
CN102341691A (zh) * 2008-12-31 2012-02-01 尹特根埃克斯有限公司 具有微流体芯片的仪器
US7927904B2 (en) 2009-01-05 2011-04-19 Dalsa Semiconductor Inc. Method of making BIOMEMS devices
EP2387627B1 (en) 2009-01-15 2016-03-30 Adaptive Biotechnologies Corporation Adaptive immunity profiling and methods for generation of monoclonal antibodies
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
ES2695039T3 (es) 2009-02-02 2018-12-28 Opko Diagnostics, Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
DE202010018569U1 (de) 2009-02-18 2017-09-26 Streck Inc. Konservierung zellfreier Nukleinsäuren
US9739771B2 (en) * 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
TWI400446B (zh) * 2009-03-20 2013-07-01 Univ Nat Cheng Kung 免疫分析晶片
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
AU2010229924B2 (en) * 2009-03-24 2016-07-21 Plus Therapeutics Inc. Devices and methods of cell capture and analysis
US9090663B2 (en) * 2009-04-21 2015-07-28 The Trustees Of Columbia University In The City Of New York Systems and methods for the capture and separation of microparticles
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
WO2010141131A1 (en) 2009-06-04 2010-12-09 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
JP2012529268A (ja) 2009-06-05 2012-11-22 インテジェンクス，インコーポレイテッド ユニバーサルサンプル調製システムおよび統合解析システムの使用方法
CN102459643B (zh) 2009-06-25 2016-06-01 弗雷德哈钦森癌症研究中心 检测获得性免疫的方法
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
EP2480887B1 (en) * 2009-09-23 2015-12-16 Koninklijke Philips N.V. Binding assay with multiple magnetically labelled tracer binding agents
DE102009043426B4 (de) * 2009-09-29 2012-05-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Gewinnung, zum Nachweis und zur Analyse von Zellen in einem mikrofluidischen System
DE102009043527B4 (de) * 2009-09-30 2021-06-10 Boehringer Ingelheim Vetmedica Gmbh Anordnung und Verfahren unter Verwendung von Mikrosensoren zum Messen von Zell-Vitalitäten
KR20120102674A (ko) 2009-11-03 2012-09-18 유니버시티 오브 버지니아 페이턴트 파운데이션 중합체 분석물을 검출하는 다용도의 가시적인 방법
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US20110117607A1 (en) * 2009-11-13 2011-05-19 3M Innovative Properties Company Annular compression systems and methods for sample processing devices
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
ES2859481T3 (es) * 2009-11-24 2021-10-04 Opko Diagnostics Llc Mezcla y suministro de fluidos en sistemas microfluídicos
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
US9733242B2 (en) 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
US8398418B2 (en) 2010-01-07 2013-03-19 Life Technologies Corporation Electronic connector having a clamping member urging a flow cell toward an electrical circuitry with an electrically conductive membrane disposed in between
KR20160088958A (ko) 2010-02-23 2016-07-26 루미넥스 코포레이션 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법
BR112012026366B1 (pt) 2010-04-16 2020-05-05 Opko Diagnostics, Llc analisador de amostras microfluídicas e método para analisar uma amostra microfluídica
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
WO2011146596A1 (en) * 2010-05-18 2011-11-24 Cyvek, Inc. Method and apparatus for performing extraction and enrichment of components in a biological sample
WO2011150226A1 (en) 2010-05-26 2011-12-01 Landers James P Method for detecting nucleic acids based on aggregate formation
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8487790B2 (en) 2010-06-30 2013-07-16 Life Technologies Corporation Chemical detection circuit including a serializer circuit
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
EP2606343A4 (en) 2010-08-18 2017-08-16 Life Technologies Corporation Chemical coating of microwell for electrochemical detection device
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
WO2012073115A1 (en) * 2010-11-30 2012-06-07 Quantumdx Group Limited Microfluidic device for nucleic acid extraction and fractionation
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092455A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
CA2827226C (en) 2011-04-27 2019-02-12 Becton Dickinson And Company Devices and methods for separating magnetically labeled moieties in a sample
WO2012151268A1 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system for high throughput optical and label free detection of analytes
WO2012151289A2 (en) 2011-05-02 2012-11-08 University Of Virginia Patent Foundation Method and system to detect aggregate formation on a substrate
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
MX336625B (es) 2011-05-18 2016-01-26 3M Innovative Properties Co Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra.
CN103648649A (zh) 2011-05-18 2014-03-19 3M创新有限公司 检测选定体积的材料在样本处理装置中存在的系统和方法
CN103998932B (zh) 2011-06-29 2017-06-06 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
EP2739587B1 (en) 2011-08-01 2020-05-27 Denovo Sciences Cell capture system
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
CN104024849A (zh) 2011-08-12 2014-09-03 生命科技公司 用于高通量聚糖分析的装置、方法、计算机程序产品和试剂盒
WO2013039778A2 (en) 2011-09-12 2013-03-21 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
US9824179B2 (en) 2011-12-09 2017-11-21 Adaptive Biotechnologies Corp. Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
EP2812708B1 (en) 2012-02-10 2019-09-04 The University of North Carolina At Chapel Hill Method of analysing an analyte with fluidic nanofunnels
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
TWI596494B (zh) 2012-03-05 2017-08-21 Ｏｐｋｏ診斷法有限責任公司 預測前列腺癌風險及前列腺腺體體積之方法及裝置
US20130337580A1 (en) * 2012-05-03 2013-12-19 Kiamars Hajizadeh Immunoassay Device and Method
CA2872468C (en) 2012-05-08 2020-10-27 Adaptive Biotechnologies Corporation Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
JP6449160B2 (ja) 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照
US10150996B2 (en) 2012-10-19 2018-12-11 Adaptive Biotechnologies Corp. Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2014066553A1 (en) 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
AU2013370934B2 (en) * 2012-12-31 2017-06-08 Eprep Pty Ltd Flow control apparatus for sample fluids
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US10261065B2 (en) 2013-02-28 2019-04-16 The University Of North Carolina At Chapel Hill Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis
WO2014164739A1 (en) 2013-03-13 2014-10-09 The University Of North Carolina At Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
ES2741001T3 (es) 2013-03-13 2020-02-07 Opko Diagnostics Llc Mezcla de fluidos en sistemas fluídicos
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
EP3608022A1 (en) 2013-03-15 2020-02-12 The Trustees of Princeton University Methods and devices for high throughput purification
EP3569313A1 (en) 2013-03-15 2019-11-20 GPB Scientific, LLC On-chip microfluidic processing of particles
US20160016171A1 (en) 2013-03-15 2016-01-21 Nanobiosym, Inc. Systems and Methods for Mobile Device Analysis of Nucleic Acids and Proteins
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
US10410739B2 (en) 2013-10-04 2019-09-10 Life Technologies Corporation Methods and systems for modeling phasing effects in sequencing using termination chemistry
CN105873681B (zh) 2013-11-18 2019-10-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
US9835623B2 (en) * 2014-01-15 2017-12-05 Caliper Life Sciences, Inc. Method and system of microfluidic immunoassay using magnetic beads
KR101562865B1 (ko) * 2014-01-24 2015-10-26 한국과학기술연구원 신경 영양인자를 감지하기 위한 초소형 센서 시스템
MX2016011474A (es) * 2014-03-05 2016-11-16 Theranos Inc Metodos y dispositivos para recoleccion de muestras y separacion de muestras.
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US20170022546A1 (en) * 2014-03-10 2017-01-26 Rashid Bashir Detection and quantification of methylation in dna
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
EP3163306A4 (en) 2014-06-30 2018-01-24 Panasonic Healthcare Holdings Co., Ltd. Substrate for sample analysis, and sample analysis apparatus
JP6588910B2 (ja) 2014-06-30 2019-10-09 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
US10539582B2 (en) 2014-06-30 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
WO2016002727A1 (ja) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
WO2016022696A1 (en) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
EP3197518B1 (en) 2014-09-25 2019-07-24 NxStage Medical, Inc. Medicament preparation and treatment devices and systems
CN107209094A (zh) * 2014-10-01 2017-09-26 塔斯马尼亚大学 萃取和浓缩装置
ES2789000T3 (es) 2014-10-10 2020-10-23 Quantapore Inc Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US10279345B2 (en) 2014-12-12 2019-05-07 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
JP6660305B2 (ja) 2014-12-12 2020-03-11 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3280532A1 (en) 2015-04-10 2018-02-14 Tumorgen MDX LLC Rare cell isolation device and method of use thereof
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US11940422B2 (en) * 2015-07-12 2024-03-26 Pharmafluidics Nv Microfluidic device
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
WO2017048815A1 (en) * 2015-09-14 2017-03-23 Singulex, Inc. Single molecule detection on a chip
EP3329279B1 (en) 2015-10-05 2021-07-07 The University of North Carolina at Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
JP7277050B2 (ja) 2016-01-29 2023-05-18 ピューリジェン バイオシステムズ， インコーポレイテッド 核酸の精製のための等速電気泳動
US11060958B2 (en) 2016-02-27 2021-07-13 Hewlett-Packard Development Company, L.P. Sample preparation system
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
EP4656715A3 (en) 2016-07-29 2026-02-25 Streck LLC Suspension composition for hematology analysis control
US11660571B2 (en) * 2016-11-18 2023-05-30 The Regents Of The University Of California Microscale device and method for purification of radiopharmaceuticals
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
US11305282B2 (en) * 2017-03-29 2022-04-19 Cornell University Devices, processes, and systems for determination of nucleic acid sequence, expression, copy number, or methylation changes using combined nuclease, ligase, polymerase, and sequencing reactions
SG11202000871WA (en) * 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
WO2019046307A1 (en) 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
CN115119829B (zh) 2017-10-19 2024-07-12 斯特雷克股份有限公司 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物
KR102245674B1 (ko) * 2017-11-17 2021-04-27 주식회사 엘지화학 고상 추출용 마이크로 디바이스
WO2019109092A1 (en) * 2017-12-01 2019-06-06 Godx, Inc. Rapid nucleic acids separation and sample preparation via hollow-centered silica microsphere
AU2019311199B2 (en) 2018-07-23 2024-12-19 Dna Script Massively parallel enzymatic synthesis of nucleic acid strands
WO2020081342A1 (en) * 2018-10-19 2020-04-23 President And Fellows Of Harvard College Smart toilet paper
JP7550055B2 (ja) 2018-11-13 2024-09-12 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル マイクロ流体デバイスを備える分析システムとマイクロ流体デバイスと関連方法
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
KR20210111262A (ko) 2019-01-03 2021-09-10 디엔에이 스크립트 올리고뉴클레오티드 세트의 원 포트 합성
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
EP3966307B1 (en) 2019-05-07 2024-11-20 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
SG11202112898WA (en) 2019-06-14 2021-12-30 Bio Rad Laboratories System and method for automated single cell processing and analyses
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
US12576400B2 (en) 2021-01-08 2026-03-17 Cellanome, Inc. Methods for incubating and analyzing a cell in a compartment of a fluidic device
JP2024502618A (ja) 2021-01-08 2024-01-22 セラノーム， インコーポレイテッド 生体試料を分析するためのデバイスおよび方法
WO2022150659A1 (en) 2021-01-08 2022-07-14 Cellanome, Inc. Devices and methods for analyzing biological samples
WO2023107539A1 (en) 2021-12-10 2023-06-15 Bio-Rad Laboratories, Inc. Compositions, methods, and systems for sample processing with morphology-adjustable functionalized particles
WO2026006318A1 (en) 2024-06-24 2026-01-02 Amplifidx, Inc. Point-of-care bioassay systems and methods of making and using the same

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5202010A (en) 1987-11-25 1993-04-13 Princeton Biochemicals, Inc. Automated capillary electrophoresis apparatus
US5006313A (en) 1988-06-02 1991-04-09 Hewlett-Packard Company Halogenated surface with reduced protein interaction
US4931328A (en) 1988-08-19 1990-06-05 Hewlett-Packard Company Capillary tube with reduced protein interactions and controllable electroosmotic flow
US5114768A (en) 1988-06-02 1992-05-19 Hewlett-Packard Company Surfaces with reduced protein interactions
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
EP0356160A3 (en) 1988-08-24 1991-09-11 The Board Of Trustees Of The Leland Stanford Junior University Capillary device
US5081030A (en) 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5110514A (en) 1989-05-01 1992-05-05 Soane Technologies, Inc. Controlled casting of a shrinkable material
US5110745A (en) 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5246577A (en) 1990-05-29 1993-09-21 Millipore Corporation Apparatus for effecting capillary electrophoresis
US5085756A (en) 1990-08-21 1992-02-04 Hewlett-Packard Company Column separation system for electrophoresis with sample pretreatment
EP0497077B1 (de) 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5340452A (en) 1991-02-01 1994-08-23 Beckman Instruments, Inc. On-column preconcentration of samples in capillary electrophoresis
US5646001A (en) 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
EP0544969B1 (de) * 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
JP3063344B2 (ja) 1991-12-18 2000-07-12 株式会社島津製作所 オンライン前処理可能なキャピラリ電気泳動方法及び装置
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
AU677780B2 (en) 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5423966A (en) 1994-01-25 1995-06-13 Perkin-Elmer Corporation On line ion contaminant removal apparatus and method for capillary electrophoresis
US5464048A (en) * 1994-02-22 1995-11-07 Allen; Edward Liquid dispenser bottles with reservoirs for droppers
DE69422604T2 (de) 1994-03-08 2000-06-08 Zeptosens Ag, Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
US5645702A (en) 1995-06-07 1997-07-08 Hewlett-Packard Company Low voltage miniaturized column analytical apparatus and method
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5658413A (en) 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5985119A (en) 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
JP3398749B2 (ja) 1994-11-10 2003-04-21 オーキッド バイオ サイエンシズ， インコーポレイテッド 液体分配システム
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
AU5360596A (en) 1995-04-06 1996-10-23 Miltenyi Biotech, Inc. Multiparameter cell separation using releasable colloidal ma gnetic particles
EP0869850B1 (en) 1995-06-06 2002-09-25 Orchid BioSciences, Inc. Forming electrical conduits through holes
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5646048A (en) 1995-07-24 1997-07-08 Hewlett-Packard Company Microcolumnar analytical apparatus with microcolumnar flow gating interface and method of using the apparatus
CA2236451A1 (en) 1995-11-03 1997-05-09 Zygmunt M. Andrevski Assay system and method for conducting assays
EP0876668A1 (en) 1995-11-03 1998-11-11 David Sarnoff Research Center, Inc. Magnet
CA2236788A1 (en) 1995-11-09 1997-05-15 David Sarnoff Research Center, Inc. Field-assisted sealing
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
CA2251160A1 (en) 1996-04-09 1997-10-16 Kerry D. O'mara Plate for reaction system
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
CN1329729C (zh) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US5804436A (en) * 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
AU4607197A (en) 1996-09-26 1998-04-17 Sarnoff Corporation Massively parallel detection
EP1018012A4 (en) * 1997-09-26 2002-10-09 Univ Washington Simultaneous particle separation and chemical reaction

Also Published As

Publication number Publication date
US20020119482A1 (en) 2002-08-29
US6613525B2 (en) 2003-09-02
WO1999040174A9 (en) 2000-02-24
US6074827A (en) 2000-06-13
JP2002502597A (ja) 2002-01-29
EP1053298A1 (en) 2000-11-22
US6344326B1 (en) 2002-02-05
AU758140B2 (en) 2003-03-13
AU2488799A (en) 1999-08-23
US20030224436A1 (en) 2003-12-04
WO1999040174A1 (en) 1999-08-12
EP1053298B1 (en) 2013-09-25
EP1053298A4 (en) 2003-04-16

Similar Documents

Publication Publication Date Title
AU758140B2 (en) Integrated microfluidic devices
EP1007953B1 (en) Integrated microfluidic devices
US7811436B2 (en) Electrophoresis apparatus having an outlet passage
US6432630B1 (en) Micro-flow system for particle separation and analysis
EP1706735B1 (en) Multi-dimensional electrophoresis apparatus
US9482602B2 (en) Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette
US8865075B2 (en) Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus
CA2424941A1 (en) An integrated biochip system for sample preparation and analysis
JP2006524319A (ja) 移動度シフトアッセイ干渉の低減
US20160341694A1 (en) Method and apparatus to concentrate and detect an analyte in a sample
WO2012065075A2 (en) Electrokinetic devices and methods for high conductance and high voltage dielectrophoresis (dep)
Zheng Microfluidics in blood-based diagnostics

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued