CA2281708C - Process for preparing eprosartan - Google Patents
Process for preparing eprosartan Download PDFInfo
- Publication number
- CA2281708C CA2281708C CA002281708A CA2281708A CA2281708C CA 2281708 C CA2281708 C CA 2281708C CA 002281708 A CA002281708 A CA 002281708A CA 2281708 A CA2281708 A CA 2281708A CA 2281708 C CA2281708 C CA 2281708C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- acid
- imidazol
- butyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3819597P | 1997-02-14 | 1997-02-14 | |
| US60/038,195 | 1997-02-14 | ||
| PCT/US1998/002412 WO1998035963A1 (en) | 1997-02-14 | 1998-02-13 | Process for preparing eprosartan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2281708A1 CA2281708A1 (en) | 1998-08-20 |
| CA2281708C true CA2281708C (en) | 2007-08-14 |
Family
ID=21898583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002281708A Expired - Fee Related CA2281708C (en) | 1997-02-14 | 1998-02-13 | Process for preparing eprosartan |
Country Status (41)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008078330A1 (en) * | 2006-12-27 | 2008-07-03 | Hetero Drugs Limited | Improved process for eprosartan |
| EP2181109A4 (en) * | 2007-07-25 | 2011-08-03 | Hetero Drugs Ltd | CRYSTALLINE PARTICLES OF EPROSARTAN MESYLATE AND PROCESS FOR PREPARING PURE EPROSARTAN |
| EP2295430A3 (en) * | 2007-07-25 | 2011-08-03 | Hetero Drugs Limited | Crystalline solid of eprosartan acetate |
| WO2009084028A2 (en) * | 2007-12-03 | 2009-07-09 | Neuland Laboratories Ltd | Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate |
| CN101215284B (zh) * | 2007-12-31 | 2010-10-13 | 浙江华海药业股份有限公司 | 一种改进的依普罗沙坦的制备方法 |
| WO2009122421A2 (en) * | 2008-03-31 | 2009-10-08 | Hetero Research Foundation | Improved process for eprosartan intermediate |
| WO2010023688A2 (en) * | 2008-08-25 | 2010-03-04 | Matrix Laboratories Limited | An improved process for the preparation of eprosartan |
| WO2011004384A2 (en) | 2009-06-05 | 2011-01-13 | Glochem Industries Limited | Process for the preparation of eprosartan |
| WO2011051975A1 (en) | 2009-10-30 | 2011-05-05 | Matrix Laboratories Ltd | An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185351A (en) * | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
| NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
| EP0563238B1 (en) * | 1990-12-14 | 2002-05-22 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| US5395847A (en) * | 1993-12-02 | 1995-03-07 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids |
| PL185858B1 (pl) * | 1994-05-20 | 2003-08-29 | Smithkline Beecham Corp | Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1H-imidazol-1-ilo)metylo]benzoesowego z wodorosiarcH-imidazol-1-ilo)metylo]benzoesowego z wodorosiarczynem i sposób jego wytwarzaniazynem i sposób jego wytwarzania |
-
1998
- 1998-02-10 AR ARP980100585A patent/AR011125A1/es active IP Right Grant
- 1998-02-11 EG EG15598A patent/EG23935A/xx active
- 1998-02-12 MY MYPI98000577A patent/MY118704A/en unknown
- 1998-02-12 MA MA24961A patent/MA24470A1/fr unknown
- 1998-02-12 PE PE1998000101A patent/PE59299A1/es not_active Application Discontinuation
- 1998-02-12 IN IN360DE1998 patent/IN187999B/en unknown
- 1998-02-13 CN CN98802484A patent/CN1085208C/zh not_active Expired - Fee Related
- 1998-02-13 ZA ZA981207A patent/ZA981207B/xx unknown
- 1998-02-13 BR BR9808664-2A patent/BR9808664A/pt not_active IP Right Cessation
- 1998-02-13 EP EP98906229A patent/EP0970073B1/en not_active Expired - Lifetime
- 1998-02-13 AU AU61508/98A patent/AU730383B2/en not_active Ceased
- 1998-02-13 NZ NZ337180A patent/NZ337180A/xx unknown
- 1998-02-13 CA CA002281708A patent/CA2281708C/en not_active Expired - Fee Related
- 1998-02-13 ES ES98906229T patent/ES2231963T3/es not_active Expired - Lifetime
- 1998-02-13 PT PT98906229T patent/PT970073E/pt unknown
- 1998-02-13 IL IL13130998A patent/IL131309A/en not_active IP Right Cessation
- 1998-02-13 WO PCT/US1998/002412 patent/WO1998035963A1/en active IP Right Grant
- 1998-02-13 JP JP52813798A patent/JP4537499B2/ja not_active Expired - Fee Related
- 1998-02-13 TR TR1999/01936T patent/TR199901936T2/xx unknown
- 1998-02-13 AT AT98906229T patent/ATE280765T1/de active
- 1998-02-13 SK SK1087-99A patent/SK285036B6/sk not_active IP Right Cessation
- 1998-02-13 HU HU0001994A patent/HU228781B1/hu not_active IP Right Cessation
- 1998-02-13 EA EA199900740A patent/EA001659B1/ru not_active IP Right Cessation
- 1998-02-13 KR KR1019997007273A patent/KR100573638B1/ko not_active IP Right Cessation
- 1998-02-13 US US09/355,185 patent/US6172237B1/en not_active Expired - Lifetime
- 1998-02-13 AP APAP/P/1999/001620A patent/AP1128A/en active
- 1998-02-13 SI SI9830722T patent/SI0970073T1/xx unknown
- 1998-02-13 PL PL335075A patent/PL192838B1/pl unknown
- 1998-02-13 CO CO98007700A patent/CO4950550A1/es unknown
- 1998-02-13 DE DE69827240T patent/DE69827240T2/de not_active Expired - Lifetime
- 1998-02-13 DK DK98906229T patent/DK0970073T3/da active
- 1998-02-13 ID IDW990839A patent/ID23181A/id unknown
- 1998-02-13 RO RO99-00885A patent/RO119719B1/ro unknown
- 1998-02-13 CZ CZ0285299A patent/CZ296349B6/cs not_active IP Right Cessation
- 1998-02-13 UA UA99084635A patent/UA54487C2/uk unknown
- 1998-04-15 TW TW087101969A patent/TW399050B/zh not_active IP Right Cessation
- 1998-05-24 SA SA98190082A patent/SA98190082B1/ar unknown
-
1999
- 1999-08-10 BG BG103650A patent/BG63804B1/bg unknown
- 1999-08-13 OA OA9900179A patent/OA11146A/en unknown
- 1999-08-13 NO NO19993913A patent/NO317194B1/no not_active IP Right Cessation
-
2002
- 2002-01-28 IN IN58DE2002 patent/IN192743B/en unknown
-
2006
- 2006-04-07 CY CY0600011A patent/CY2555B1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2281708C (en) | Process for preparing eprosartan | |
| US6458963B1 (en) | Process for preparing eprosartan using regioselective protection of 2,4-disubstituted-imidazole intermediates | |
| MXPA99007533A (en) | Process for preparing eprosartan | |
| MXPA99007536A (en) | Process for preparing eprosartan |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160215 |