CA2178482C - Thrombopoietin - Google Patents

Thrombopoietin Download PDF

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Publication number
CA2178482C
CA2178482C CA2178482A CA2178482A CA2178482C CA 2178482 C CA2178482 C CA 2178482C CA 2178482 A CA2178482 A CA 2178482A CA 2178482 A CA2178482 A CA 2178482A CA 2178482 C CA2178482 C CA 2178482C
Authority
CA
Canada
Prior art keywords
mpl ligand
mpl
cells
ligand
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2178482A
Other languages
English (en)
French (fr)
Other versions
CA2178482A1 (en
Inventor
Dan L. Eaton
Frederic J. De Sauvage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2178482A1 publication Critical patent/CA2178482A1/en
Application granted granted Critical
Publication of CA2178482C publication Critical patent/CA2178482C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2178482A 1994-01-03 1994-12-28 Thrombopoietin Expired - Lifetime CA2178482C (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US08/176553 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/185607 1994-01-21
US08/196689 1994-02-15
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/223263 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US08/249376 1994-05-25
US34865894A 1994-12-02 1994-12-02
US08/348658 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand
US08/348657 1994-12-02
PCT/US1994/014553 WO1995018858A1 (en) 1994-01-03 1994-12-28 Thrombopoietin

Publications (2)

Publication Number Publication Date
CA2178482A1 CA2178482A1 (en) 1995-07-13
CA2178482C true CA2178482C (en) 2012-01-03

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2178482A Expired - Lifetime CA2178482C (en) 1994-01-03 1994-12-28 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (it)
JP (2) JPH09508262A (it)
CN (1) CN1134539C (it)
AU (1) AU704266B2 (it)
BG (1) BG63639B1 (it)
CA (1) CA2178482C (it)
CZ (1) CZ296130B6 (it)
DK (1) DK149194A (it)
ES (1) ES2114786B1 (it)
FI (1) FI121573B (it)
FR (1) FR2714670B1 (it)
GB (1) GB2285446B (it)
HR (1) HRP941020A2 (it)
HU (1) HUT75657A (it)
IE (1) IE72517B1 (it)
IL (1) IL112184A (it)
IT (1) IT1283770B1 (it)
LU (1) LU88573A1 (it)
LV (1) LV11632B (it)
NL (1) NL9500010A (it)
NO (1) NO326903B1 (it)
NZ (1) NZ278726A (it)
PT (1) PT101627B (it)
RO (1) RO117110B1 (it)
SG (1) SG47030A1 (it)
SI (1) SI9420079A (it)
SK (1) SK282265B6 (it)
WO (1) WO1995018858A1 (it)

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US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
EP0755263A4 (en) * 1994-03-31 2005-02-09 Amgen Inc COMPOUNDS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND THEIR DIFFERENTIATION
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
CA2212006A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. Novel c-mpl ligands
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
CN1315870C (zh) 1995-06-07 2007-05-16 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
KR20000029998A (ko) * 1996-08-13 2000-05-25 리스 데브라 케이. 발현벡터,세포,그리고혈소판조혈인자를제조하는방법
EP0983082A1 (en) * 1997-05-21 2000-03-08 Genentech, Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
HU228582B1 (en) 1998-10-23 2013-04-29 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1994824A1 (en) 2001-11-15 2008-11-26 Kirin Pharma Kabushiki Kaisha Chimeric non-human animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
ES2462916T3 (es) 2002-09-18 2014-05-26 Janssen Pharmaceuticals, Inc. Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
SI1675606T1 (sl) 2003-08-28 2017-07-31 Janssen Pharmaceuticals, Inc. Peptidi in spojine, ki se vežejo na trombopoietinske receptorje
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
NZ583974A (en) 2004-05-18 2011-11-25 Intrexon Corp Methods for dynamic vector assembly of DNA cloning vector plasmids
US8143380B2 (en) 2004-07-08 2012-03-27 Amgen Inc. Therapeutic peptides
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
JP5543778B2 (ja) 2006-07-24 2014-07-09 ザ・ユニバーシティ・オブ・クイーンズランド 細胞集団を産生する方法
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
CA2687141C (en) 2007-05-22 2014-04-01 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
US20110294733A1 (en) 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
RU2694064C1 (ru) * 2015-12-21 2019-07-09 Браинон Инк. Композиция для улучшения памяти, способности к обучению и когнитивных способностей
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
PE20220604A1 (es) * 2019-09-20 2022-04-25 Ractigen Therapeutics Molecula de acido nucleico para el tratamiento de la trombocitopenia y uso de la misma
CA3164986A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

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US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
ATE204606T1 (de) * 1991-12-06 2001-09-15 Genentech Inc Prohormon konvertase transformierte zellen.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
SI9420079A (en) 1997-02-28
IL112184A (en) 2004-07-25
GB9425831D0 (en) 1995-02-22
GB2285446B (en) 1999-07-28
CZ192296A3 (en) 1997-05-14
FR2714670A1 (fr) 1995-07-07
FR2714670B1 (fr) 1997-01-10
IT1283770B1 (it) 1998-04-30
ITTO950002A0 (it) 1995-01-02
FI121573B (fi) 2011-01-14
HRP941020A2 (en) 1997-04-30
GB2285446A (en) 1995-07-12
JPH09508262A (ja) 1997-08-26
CZ296130B6 (cs) 2006-01-11
CN1134539C (zh) 2004-01-14
ES2114786B1 (es) 1999-01-01
LU88573A1 (de) 1995-06-01
ES2114786A1 (es) 1998-06-01
EP0738323A1 (en) 1996-10-23
NO962783L (no) 1996-09-03
SK87596A3 (en) 1997-11-05
JPH10113186A (ja) 1998-05-06
FI962723A (fi) 1996-09-03
PT101627A (pt) 1995-11-30
BG63639B1 (bg) 2002-07-31
HUT75657A (en) 1997-05-28
FI962723A0 (fi) 1996-07-02
IE950002A1 (en) 1995-07-12
ITTO950002A1 (it) 1995-07-03
LV11632B (en) 1997-04-20
CA2178482A1 (en) 1995-07-13
CN1141061A (zh) 1997-01-22
SK282265B6 (sk) 2001-12-03
IE72517B1 (en) 1997-04-23
NZ278726A (en) 1998-06-26
SG47030A1 (en) 1998-03-20
RO117110B1 (ro) 2001-10-30
BG100693A (en) 1998-01-30
AU704266B2 (en) 1999-04-15
WO1995018858A1 (en) 1995-07-13
NO326903B1 (no) 2009-03-16
PT101627B (pt) 1996-11-29
IL112184A0 (en) 1995-03-15
NO962783D0 (no) 1996-07-02
AU1514695A (en) 1995-08-01
LV11632A (lv) 1996-12-20
HU9601805D0 (en) 1996-08-28
NL9500010A (nl) 1995-08-01
DK149194A (da) 1995-07-04

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Effective date: 20141229