CN1134539C - 血小板生成素 - Google Patents
血小板生成素 Download PDFInfo
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- CN1134539C CN1134539C CNB941947513A CN94194751A CN1134539C CN 1134539 C CN1134539 C CN 1134539C CN B941947513 A CNB941947513 A CN B941947513A CN 94194751 A CN94194751 A CN 94194751A CN 1134539 C CN1134539 C CN 1134539C
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Vehicle Body Suspensions (AREA)
- Information Transfer Systems (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17655394A | 1994-01-03 | 1994-01-03 | |
| US08/176,553 | 1994-01-03 | ||
| US18560794A | 1994-01-21 | 1994-01-21 | |
| US08/185,607 | 1994-01-21 | ||
| US08/196,689 | 1994-02-15 | ||
| US08/196,689 US8357513B1 (en) | 1994-01-03 | 1994-02-15 | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
| US22326394A | 1994-04-04 | 1994-04-04 | |
| US08/223,263 | 1994-04-04 | ||
| US08/249,376 US8192955B1 (en) | 1994-01-03 | 1994-05-25 | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
| US08/249,376 | 1994-05-25 | ||
| US34865894A | 1994-12-02 | 1994-12-02 | |
| US08/348,657 | 1994-12-02 | ||
| US08/348,657 US6660256B1 (en) | 1994-01-03 | 1994-12-02 | Porcine mpl ligand |
| US08/348,658 | 1994-12-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1141061A CN1141061A (zh) | 1997-01-22 |
| CN1134539C true CN1134539C (zh) | 2004-01-14 |
Family
ID=27569151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB941947513A Expired - Lifetime CN1134539C (zh) | 1994-01-03 | 1994-12-28 | 血小板生成素 |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0738323A1 (it) |
| JP (2) | JPH09508262A (it) |
| CN (1) | CN1134539C (it) |
| AU (1) | AU704266B2 (it) |
| BG (1) | BG63639B1 (it) |
| CA (1) | CA2178482C (it) |
| CZ (1) | CZ296130B6 (it) |
| DK (1) | DK149194A (it) |
| ES (1) | ES2114786B1 (it) |
| FI (1) | FI121573B (it) |
| FR (1) | FR2714670B1 (it) |
| GB (1) | GB2285446B (it) |
| HR (1) | HRP941020A2 (it) |
| HU (1) | HUT75657A (it) |
| IE (1) | IE72517B1 (it) |
| IL (1) | IL112184A (it) |
| IT (1) | IT1283770B1 (it) |
| LU (1) | LU88573A1 (it) |
| LV (1) | LV11632B (it) |
| NL (1) | NL9500010A (it) |
| NO (1) | NO326903B1 (it) |
| NZ (1) | NZ278726A (it) |
| PT (1) | PT101627B (it) |
| RO (1) | RO117110B1 (it) |
| SG (1) | SG47030A1 (it) |
| SI (1) | SI9420079A (it) |
| SK (1) | SK282265B6 (it) |
| WO (1) | WO1995018858A1 (it) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2810503C1 (ru) * | 2023-02-13 | 2023-12-27 | Общество С Ограниченной Ответственностью "Герофарм" | Тест-система и способы определения биологической активности агонистов рецептора тромбопоэтина человека |
| EP3255055B1 (en) * | 2015-12-21 | 2024-06-05 | BrainOn Inc. | Composition for improving memory, learning ability and cognition |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| EP0755263A4 (en) * | 1994-03-31 | 2005-02-09 | Amgen Inc | COMPOUNDS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND THEIR DIFFERENTIATION |
| US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
| TW387940B (en) * | 1995-01-17 | 2000-04-21 | Kirin Brewery | Anti-tpo monodonal antibody |
| CA2212006A1 (en) | 1995-02-03 | 1996-08-08 | G.D. Searle & Co. | Novel c-mpl ligands |
| AU691410B2 (en) * | 1995-02-15 | 1998-05-14 | Amgen, Inc. | MPL ligand analogs |
| US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
| US5696250A (en) * | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
| TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
| TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
| ZA964382B (en) * | 1995-06-06 | 1997-12-01 | Genentech Inc | Lymphotoxin and thrombopoietin for use in the treatment of cancer. |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| CN1315870C (zh) | 1995-06-07 | 2007-05-16 | 葛兰素集团有限公司 | 结合血小板生成素受体的肽和化合物 |
| TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
| US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
| US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| KR20000029998A (ko) * | 1996-08-13 | 2000-05-25 | 리스 데브라 케이. | 발현벡터,세포,그리고혈소판조혈인자를제조하는방법 |
| EP0983082A1 (en) * | 1997-05-21 | 2000-03-08 | Genentech, Inc. | Novel administration of thrombopoietin |
| US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| KR20000006549A (ko) * | 1998-06-30 | 2000-01-25 | 윤재승 | 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체 |
| US20030228666A1 (en) | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
| HU228582B1 (en) | 1998-10-23 | 2013-04-29 | Kirin Amgen Inc | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
| UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
| US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| EP1994824A1 (en) | 2001-11-15 | 2008-11-26 | Kirin Pharma Kabushiki Kaisha | Chimeric non-human animal |
| KR100467750B1 (ko) * | 2001-11-29 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| ES2462916T3 (es) | 2002-09-18 | 2014-05-26 | Janssen Pharmaceuticals, Inc. | Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas |
| SI1675606T1 (sl) | 2003-08-28 | 2017-07-31 | Janssen Pharmaceuticals, Inc. | Peptidi in spojine, ki se vežejo na trombopoietinske receptorje |
| US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| NZ583974A (en) | 2004-05-18 | 2011-11-25 | Intrexon Corp | Methods for dynamic vector assembly of DNA cloning vector plasmids |
| US8143380B2 (en) | 2004-07-08 | 2012-03-27 | Amgen Inc. | Therapeutic peptides |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
| WO2007098547A1 (en) * | 2006-03-01 | 2007-09-07 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| JP5543778B2 (ja) | 2006-07-24 | 2014-07-09 | ザ・ユニバーシティ・オブ・クイーンズランド | 細胞集団を産生する方法 |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| CA2687141C (en) | 2007-05-22 | 2014-04-01 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| US20110294733A1 (en) | 2009-01-20 | 2011-12-01 | Hanall Biopharma Co., Ltd. | Modified human thrombopoietin polypeptide fragment and manufacturing method thereof |
| WO2014089478A1 (en) * | 2012-12-07 | 2014-06-12 | University Of Tennessee Research Foundation | Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same |
| CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| CN103555760B (zh) * | 2013-10-18 | 2015-05-20 | 江苏康禾生物制药有限公司 | 一种重组人血小板生成素的制备方法及其制剂 |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| PE20220604A1 (es) * | 2019-09-20 | 2022-04-25 | Ractigen Therapeutics | Molecula de acido nucleico para el tratamiento de la trombocitopenia y uso de la misma |
| CA3164986A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260417A (en) | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
| AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
| ATE204606T1 (de) * | 1991-12-06 | 2001-09-15 | Genentech Inc | Prohormon konvertase transformierte zellen. |
| IL139335A (en) | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
-
1994
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en active IP Right Grant
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
- 1994-12-30 ES ES09402681A patent/ES2114786B1/es not_active Expired - Fee Related
- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
-
1995
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
-
1996
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
-
1997
- 1997-03-27 JP JP9074906A patent/JPH10113186A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3255055B1 (en) * | 2015-12-21 | 2024-06-05 | BrainOn Inc. | Composition for improving memory, learning ability and cognition |
| RU2810503C1 (ru) * | 2023-02-13 | 2023-12-27 | Общество С Ограниченной Ответственностью "Герофарм" | Тест-система и способы определения биологической активности агонистов рецептора тромбопоэтина человека |
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