CA2015687C - Human serum albomin fusion polypeptide - Google Patents
Human serum albomin fusion polypeptide Download PDFInfo
- Publication number
- CA2015687C CA2015687C CA002015687A CA2015687A CA2015687C CA 2015687 C CA2015687 C CA 2015687C CA 002015687 A CA002015687 A CA 002015687A CA 2015687 A CA2015687 A CA 2015687A CA 2015687 C CA2015687 C CA 2015687C
- Authority
- CA
- Canada
- Prior art keywords
- hsa
- variant
- terminal
- fusion polypeptide
- terminal portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898909916A GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
| GBGB8909916.2 | 1989-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2015687A1 CA2015687A1 (en) | 1990-10-29 |
| CA2015687C true CA2015687C (en) | 2000-08-29 |
Family
ID=10656000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002015687A Expired - Lifetime CA2015687C (en) | 1989-04-29 | 1990-04-27 | Human serum albomin fusion polypeptide |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0470165A1 (xx) |
| JP (1) | JP2781459B2 (xx) |
| KR (1) | KR100227167B1 (xx) |
| AU (1) | AU630450B2 (xx) |
| CA (1) | CA2015687C (xx) |
| FI (1) | FI104255B (xx) |
| GB (2) | GB8909916D0 (xx) |
| HU (1) | HUT61049A (xx) |
| IE (1) | IE67651B1 (xx) |
| IL (1) | IL94243A (xx) |
| WO (1) | WO1990013653A1 (xx) |
| ZA (1) | ZA903237B (xx) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
| US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2686900B1 (fr) * | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
| WO1994016085A2 (en) * | 1992-12-30 | 1994-07-21 | Zymogenetics, Inc. | Hybrid proteins having cross-linking and tissue-binding activities |
| GB9408466D0 (en) * | 1994-04-27 | 1994-06-22 | Univ Nottingham | Cloning and functional expression of neurotoxins |
| US5543308A (en) * | 1994-10-18 | 1996-08-06 | New England Biolabs, Inc. | Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same |
| US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
| US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
| US6423512B1 (en) | 1996-07-26 | 2002-07-23 | Novartis Ag | Fusion polypeptides |
| MY120425A (en) * | 1996-07-26 | 2005-10-31 | Novartis Ag | Fusion polypeptides |
| US5932693A (en) * | 1996-12-10 | 1999-08-03 | Washington University | Antithrombotic peptides |
| KR20010034305A (ko) | 1998-01-23 | 2001-04-25 | 한센 핀 베네드 | 효모에서 원하는 폴리펩티드를 만드는 방법 |
| DE69933216T2 (de) | 1998-06-15 | 2007-09-20 | GTC Biotherapeutics, Inc., Framingham | Erythropoietin-analog-menschliches serum-albumin fusionsprotein |
| CA2405701A1 (en) * | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7910368B2 (en) | 2001-08-15 | 2011-03-22 | Takara Bio Inc. | Method of extended culture for antigen-specific cytotoxic lymphocytes |
| CA2471363C (en) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP4406566B2 (ja) | 2002-03-25 | 2010-01-27 | タカラバイオ株式会社 | 細胞傷害性リンパ球の製造方法 |
| MXPA06002039A (es) | 2003-08-22 | 2006-05-25 | Takara Bio Inc | Proceso para producir linfocitos citotoxicos. |
| ES2622522T3 (es) | 2003-08-26 | 2017-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| JP5631533B2 (ja) | 2004-12-23 | 2014-11-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 遺伝子発現技術 |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| WO2007146038A2 (en) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2657277C (en) | 2006-07-13 | 2015-11-24 | Upperton Limited | Process for preparing particles of proteinaceous material |
| JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
| BR112012009450A2 (pt) | 2009-10-30 | 2017-05-23 | Novozymes Biopharma Dk As | variantes de albumina |
| CN106977608A (zh) | 2010-04-09 | 2017-07-25 | 阿尔布麦狄克斯公司 | 白蛋白衍生物和变体 |
| US9938353B2 (en) * | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| US9944691B2 (en) | 2012-03-16 | 2018-04-17 | Albumedix A/S | Albumin variants |
| GB2512156A (en) | 2012-11-08 | 2014-09-24 | Novozymes Biopharma Dk As | Albumin variants |
| US20160152686A1 (en) | 2013-03-13 | 2016-06-02 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto |
| CN108137674B (zh) | 2015-08-20 | 2022-12-06 | 阿尔布梅迪克斯医疗有限公司 | 白蛋白变体和缀合物 |
| WO2018089702A1 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE459586B (sv) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
| GB8725529D0 (en) * | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
-
1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
-
1990
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en active IP Right Grant
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 EP EP90907285A patent/EP0470165A1/en active Pending
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
-
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active IP Right Cessation
- 1991-10-28 FI FI915073A patent/FI104255B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2015687A1 (en) | 1990-10-29 |
| WO1990013653A1 (en) | 1990-11-15 |
| FI915073A0 (fi) | 1991-10-28 |
| IL94243A0 (en) | 1991-01-31 |
| IE67651B1 (en) | 1996-04-17 |
| KR920701451A (ko) | 1992-08-11 |
| IL94243A (en) | 1995-10-31 |
| IE901554L (en) | 1990-10-29 |
| JP2781459B2 (ja) | 1998-07-30 |
| JPH04506598A (ja) | 1992-11-19 |
| KR100227167B1 (ko) | 1999-10-15 |
| AU5564690A (en) | 1990-11-29 |
| AU630450B2 (en) | 1992-10-29 |
| FI104255B1 (fi) | 1999-12-15 |
| GB2246783A (en) | 1992-02-12 |
| HUT61049A (en) | 1992-11-30 |
| HU904413D0 (en) | 1992-01-28 |
| GB8909916D0 (en) | 1989-06-14 |
| GB2246783B (en) | 1992-10-14 |
| GB9119043D0 (en) | 1991-12-04 |
| ZA903237B (en) | 1991-03-27 |
| EP0470165A1 (en) | 1992-02-12 |
| FI104255B (fi) | 1999-12-15 |
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