GB2246783B - Fusion proteins containing n-terminal fragments of human serum albumin - Google Patents
Fusion proteins containing n-terminal fragments of human serum albuminInfo
- Publication number
- GB2246783B GB2246783B GB9119043A GB9119043A GB2246783B GB 2246783 B GB2246783 B GB 2246783B GB 9119043 A GB9119043 A GB 9119043A GB 9119043 A GB9119043 A GB 9119043A GB 2246783 B GB2246783 B GB 2246783B
- Authority
- GB
- United Kingdom
- Prior art keywords
- fusion proteins
- serum albumin
- human serum
- proteins containing
- terminal fragments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000008100 Human Serum Albumin Human genes 0.000 title 1
- 108091006905 Human Serum Albumin Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 210000004898 n-terminal fragment Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898909916A GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9119043D0 GB9119043D0 (en) | 1991-12-04 |
GB2246783A GB2246783A (en) | 1992-02-12 |
GB2246783B true GB2246783B (en) | 1992-10-14 |
Family
ID=10656000
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB898909916A Pending GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
GB9119043A Expired - Lifetime GB2246783B (en) | 1989-04-29 | 1991-09-06 | Fusion proteins containing n-terminal fragments of human serum albumin |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB898909916A Pending GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0470165A1 (en) |
JP (1) | JP2781459B2 (en) |
KR (1) | KR100227167B1 (en) |
AU (1) | AU630450B2 (en) |
CA (1) | CA2015687C (en) |
FI (1) | FI104255B1 (en) |
GB (2) | GB8909916D0 (en) |
HU (1) | HUT61049A (en) |
IE (1) | IE67651B1 (en) |
IL (1) | IL94243A (en) |
WO (1) | WO1990013653A1 (en) |
ZA (1) | ZA903237B (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
FR2686900B1 (en) * | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | NOVEL POLYPEPTIDES HAVING GRANULOCYTE COLONY STIMULATION ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR2686899B1 (en) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
WO1994016085A2 (en) * | 1992-12-30 | 1994-07-21 | Zymogenetics, Inc. | Hybrid proteins having cross-linking and tissue-binding activities |
GB9408466D0 (en) * | 1994-04-27 | 1994-06-22 | Univ Nottingham | Cloning and functional expression of neurotoxins |
US5543308A (en) * | 1994-10-18 | 1996-08-06 | New England Biolabs, Inc. | Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same |
US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
AR008077A1 (en) * | 1996-07-26 | 1999-12-09 | Talarico Salinas Laura Beatriz | A FUSION POLYPEPTIDE OR A SALT OF THE SAME, ITS USE, A PROCESS TO PREPARE THEM, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, AND A VECTOR. |
US6423512B1 (en) | 1996-07-26 | 2002-07-23 | Novartis Ag | Fusion polypeptides |
US5932693A (en) * | 1996-12-10 | 1999-08-03 | Washington University | Antithrombotic peptides |
EP1049790A1 (en) | 1998-01-23 | 2000-11-08 | Novo Nordisk A/S | Process for making desired polypeptides in yeast |
US6548653B1 (en) | 1998-06-15 | 2003-04-15 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
CA2405912A1 (en) * | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
TW200718784A (en) | 2001-08-15 | 2007-05-16 | Takara Bio Inc | Method of extended culture for antigen-specific cytotoxic T lumphocytes |
ES2545090T3 (en) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Albumin and GCSF fusion proteins |
CA2479288C (en) | 2002-03-25 | 2015-02-24 | Takara Bio Inc. | Process for producing cytotoxic lymphocyte |
AU2004267313B2 (en) | 2003-08-22 | 2009-09-24 | Takara Bio Inc. | Process for producing cytotoxic lymphocytes |
EP2520654B8 (en) | 2003-08-26 | 2017-04-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
WO2007146038A2 (en) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2657277C (en) | 2006-07-13 | 2015-11-24 | Upperton Limited | Process for preparing particles of proteinaceous material |
JP5936112B2 (en) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | Albumin variants and complexes |
GB2488077A (en) | 2009-10-30 | 2012-08-15 | Novozymes Biopharma Dk As | Albumin variants |
CN106977608A (en) | 2010-04-09 | 2017-07-25 | 阿尔布麦狄克斯公司 | Albumin derivant and variant |
EP2723370A4 (en) * | 2011-06-24 | 2015-06-03 | Univ Colorado Regents | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
WO2013075066A2 (en) | 2011-11-18 | 2013-05-23 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
CN104736559B (en) | 2012-03-16 | 2022-04-08 | 阿尔布梅迪克斯医疗有限公司 | Albumin variants |
EP2917233A1 (en) | 2012-11-08 | 2015-09-16 | Novozymes Biopharma DK A/S | Albumin variants |
EP2968587A2 (en) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
EP3337816B1 (en) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin variants and conjugates |
WO2018089702A1 (en) * | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002467A1 (en) * | 1987-09-14 | 1989-03-23 | Skandigen Ab | Artificial gene coding for authentic human serum albumin, use thereof, and method of producing the same |
EP0322094A1 (en) * | 1987-10-30 | 1989-06-28 | Delta Biotechnology Limited | N-terminal fragments of human serum albumin |
-
1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
-
1990
- 1990-04-26 EP EP90907285A patent/EP0470165A1/en active Pending
- 1990-04-26 JP JP2506978A patent/JP2781459B2/en not_active Expired - Lifetime
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en active IP Right Grant
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 HU HU904413A patent/HUT61049A/en unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-27 ZA ZA903237A patent/ZA903237B/en unknown
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
-
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/en not_active IP Right Cessation
- 1991-10-28 FI FI915073A patent/FI104255B1/en active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002467A1 (en) * | 1987-09-14 | 1989-03-23 | Skandigen Ab | Artificial gene coding for authentic human serum albumin, use thereof, and method of producing the same |
EP0322094A1 (en) * | 1987-10-30 | 1989-06-28 | Delta Biotechnology Limited | N-terminal fragments of human serum albumin |
Also Published As
Publication number | Publication date |
---|---|
FI104255B (en) | 1999-12-15 |
AU630450B2 (en) | 1992-10-29 |
CA2015687C (en) | 2000-08-29 |
WO1990013653A1 (en) | 1990-11-15 |
FI915073A0 (en) | 1991-10-28 |
IL94243A (en) | 1995-10-31 |
KR920701451A (en) | 1992-08-11 |
IE67651B1 (en) | 1996-04-17 |
HU904413D0 (en) | 1992-01-28 |
JP2781459B2 (en) | 1998-07-30 |
KR100227167B1 (en) | 1999-10-15 |
IE901554L (en) | 1990-10-29 |
GB8909916D0 (en) | 1989-06-14 |
FI104255B1 (en) | 1999-12-15 |
GB2246783A (en) | 1992-02-12 |
AU5564690A (en) | 1990-11-29 |
JPH04506598A (en) | 1992-11-19 |
IL94243A0 (en) | 1991-01-31 |
HUT61049A (en) | 1992-11-30 |
EP0470165A1 (en) | 1992-02-12 |
CA2015687A1 (en) | 1990-10-29 |
ZA903237B (en) | 1991-03-27 |
GB9119043D0 (en) | 1991-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE20 | Patent expired after termination of 20 years |
Expiry date: 20100425 |