CA1262553A - Cis-1-aryl-2-(fluoromethyl) oxiranes - Google Patents

Cis-1-aryl-2-(fluoromethyl) oxiranes

Info

Publication number
CA1262553A
CA1262553A CA000490974A CA490974A CA1262553A CA 1262553 A CA1262553 A CA 1262553A CA 000490974 A CA000490974 A CA 000490974A CA 490974 A CA490974 A CA 490974A CA 1262553 A CA1262553 A CA 1262553A
Authority
CA
Canada
Prior art keywords
aryl
fluoro
threo
cis
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000490974A
Other languages
English (en)
French (fr)
Inventor
Tattanahali L. Nagabhushan
Stuart W. Mccombie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of CA1262553A publication Critical patent/CA1262553A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/14—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic peracids, or salts, anhydrides or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA000490974A 1984-09-19 1985-09-18 Cis-1-aryl-2-(fluoromethyl) oxiranes Expired CA1262553A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/651,980 US4582918A (en) 1984-09-19 1984-09-19 Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US651,980 1984-09-19

Publications (1)

Publication Number Publication Date
CA1262553A true CA1262553A (en) 1989-10-31

Family

ID=24615030

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000490974A Expired CA1262553A (en) 1984-09-19 1985-09-18 Cis-1-aryl-2-(fluoromethyl) oxiranes

Country Status (18)

Country Link
US (1) US4582918A (OSRAM)
EP (1) EP0200739B1 (OSRAM)
JP (1) JPS62500519A (OSRAM)
KR (1) KR900001509B1 (OSRAM)
AR (1) AR245445A1 (OSRAM)
AT (1) ATE44735T1 (OSRAM)
AU (1) AU577622B2 (OSRAM)
CA (1) CA1262553A (OSRAM)
DE (1) DE3571613D1 (OSRAM)
DK (1) DK173703B1 (OSRAM)
ES (1) ES8702339A1 (OSRAM)
HU (1) HU196198B (OSRAM)
IE (1) IE58491B1 (OSRAM)
IL (1) IL76432A (OSRAM)
NZ (1) NZ213508A (OSRAM)
SG (1) SG39092G (OSRAM)
WO (1) WO1986001799A1 (OSRAM)
ZA (1) ZA857132B (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
DE3543021A1 (de) * 1985-12-05 1987-06-11 Boehringer Mannheim Gmbh Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte
US5084583A (en) * 1989-10-12 1992-01-28 E. I. Du Pont De Nemours And Company Epoxidation of fluorine containing olefins
IT1249048B (it) 1991-02-21 1995-02-11 Zambon Spa Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
IL134144A (en) * 1999-02-19 2004-02-08 Akzo Nobel Nv Process for the preparation of a-droxy organic acids
BR0308289A (pt) * 2002-03-08 2005-01-11 Schering Plough Ltd Antibióticos do tipo florfenicol
US20040202762A1 (en) * 2003-04-08 2004-10-14 Ducharme Paul E Smoked nonfibrous casing
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
MX2007001811A (es) * 2004-08-13 2007-03-26 Schering Plough Ltd Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticoesteroide.
US7312248B2 (en) 2004-09-23 2007-12-25 Schering-Plough Animal Health Corporation Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
MX2007006072A (es) * 2004-11-19 2007-07-11 Schering Plough Ltd Control de parasitos en animales mediante el uso de derivados del parasiticida 2-fenil-3-(1h-pirrol-2-il)acrilonitrilo.
DK1830885T3 (da) * 2004-12-21 2009-01-05 Intervet Int Bv Injicerbar veterinærmedicinsk sammensætning omfattende florfenicol
MX2007015729A (es) * 2005-06-09 2008-02-21 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida.
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
RU2009143731A (ru) * 2007-04-27 2011-06-10 Шеринг-Плоу Лтд. (CH) Соединения и способы улучшения растворимости флорфеникола и структурно родственных антибиотиков с помощью циклодекстринов
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
LT2957284T (lt) 2007-06-27 2018-04-10 E. I. Du Pont De Nemours And Company Kovos su gyvūnų kenkėjais būdas
NZ585219A (en) * 2007-11-09 2012-11-30 Intervet Int Bv Fast release solid formulation, preparation and use thereof
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
WO2011017347A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
BR112012002519A2 (pt) 2009-08-05 2019-09-24 Du Pont "pesticidas mesoiônicos"
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
EP2576523B1 (en) 2010-05-27 2016-01-13 E. I. du Pont de Nemours and Company Crystalline form of 4-[5 - [3 -chloro-5 -(trifluoromethyl)phenyl] -4,5 -dihydro-5 -(trifluoromethyl)-3 - isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naphthalenecarboxamide
JP5716349B2 (ja) * 2010-10-22 2015-05-13 住友化学株式会社 エポキシアルコール化合物の取得方法、並びにエポキシアルコール化合物及びトリアゾール化合物の製造方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD83161A (OSRAM) *
US3849482A (en) * 1967-10-30 1974-11-19 Merck & Co Inc Amine salts of cis-propenylphosphonic acid
LU79970A1 (fr) * 1978-07-13 1980-02-14 Continental Pharma Procede de preparation de derives de 1-phenyl-1-propanol
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
ES488154A0 (es) * 1979-02-05 1981-04-16 Schering Corp Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol

Also Published As

Publication number Publication date
WO1986001799A1 (en) 1986-03-27
IL76432A (en) 1989-02-28
AU577622B2 (en) 1988-09-29
HUT45243A (en) 1988-06-28
HU196198B (en) 1988-10-28
EP0200739B1 (en) 1989-07-19
DE3571613D1 (en) 1989-08-24
ATE44735T1 (de) 1989-08-15
AU4809785A (en) 1986-04-08
IE852296L (en) 1986-03-19
ES8702339A1 (es) 1986-12-16
AR245445A1 (es) 1994-01-31
JPH0529216B2 (OSRAM) 1993-04-28
SG39092G (en) 1992-05-22
KR900001509B1 (ko) 1990-03-12
ZA857132B (en) 1986-05-28
DK173703B1 (da) 2001-07-09
NZ213508A (en) 1989-05-29
EP0200739A1 (en) 1986-11-12
JPS62500519A (ja) 1987-03-05
ES547083A0 (es) 1986-12-16
DK224086A (da) 1986-05-14
IL76432A0 (en) 1986-01-31
KR870700614A (ko) 1987-12-30
IE58491B1 (en) 1993-09-22
DK224086D0 (da) 1986-05-14
US4582918A (en) 1986-04-15

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