ES8104203A1 - Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol - Google Patents
Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanolInfo
- Publication number
- ES8104203A1 ES8104203A1 ES80488154A ES488154A ES8104203A1 ES 8104203 A1 ES8104203 A1 ES 8104203A1 ES 80488154 A ES80488154 A ES 80488154A ES 488154 A ES488154 A ES 488154A ES 8104203 A1 ES8104203 A1 ES 8104203A1
- Authority
- ES
- Spain
- Prior art keywords
- methods
- acylamido
- fluoro
- aryl
- propanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DERIVADOS DE D-(TREO)-1-ARIL-2-ACILAMIDO-3-FLUOR-1-PROPANOL DE FORMULA (I), Y DE SUS SALES FARMACOLOGICAMENTE ACEPTABLES, EN LA QUE R, X Y X'' PUEDEN SER DIVERSOS RADICALES Y Z ES HIDROGENO O UN RADICAL ACILO DE UN ACIDO CARBOXILICO DE HASTA 16 ATOMOS DE CARBONO. EL PROCEDIMIENTO CONSISTE EN LA N-ACILACION DE UNA AMINA DE FORMULA (II), EN LA QUE X, X'' Y Z TIENEN EL MISMO SIGNIFICADO DE LA FORMULA (I), CON UN ACIDO R-COOH, SIENDO R EL MISMO RADICAL QUE EN LA FORMULA (I), O CON UN DERIVADO REACTIVO DE TAL ACIDO. EN EL CASO DE OBTENCION DE SALES, Z ES UN RADICAL ACILO DE ACIDO DICARBOXILICO O UN AMINOACIDO. LOS COMPUESTOS DE FORMULA (I) TIENEN APLICACION FARMACOLOGICA COMO ANTIBIOTICOS DE AMPLIO ESPECTRO. -
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/009,207 US4235892A (en) | 1979-02-05 | 1979-02-05 | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
ZA00800478A ZA80478B (en) | 1979-02-05 | 1980-01-28 | Novel 1-aryl-2-acylamido-3-fluoro-1-propanols,their preparation and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES488154A0 ES488154A0 (es) | 1981-04-16 |
ES8104203A1 true ES8104203A1 (es) | 1981-04-16 |
Family
ID=26679196
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES80488154A Expired ES8104203A1 (es) | 1979-02-05 | 1980-01-31 | Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol |
ES494632A Granted ES494632A0 (es) | 1979-02-05 | 1980-08-29 | Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol |
ES494633A Granted ES494633A0 (es) | 1979-02-05 | 1980-08-29 | Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES494632A Granted ES494632A0 (es) | 1979-02-05 | 1980-08-29 | Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol |
ES494633A Granted ES494633A0 (es) | 1979-02-05 | 1980-08-29 | Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol |
Country Status (2)
Country | Link |
---|---|
US (1) | US4311857A (es) |
ES (3) | ES8104203A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8322983D0 (en) * | 1983-08-26 | 1983-09-28 | Pfizer Ltd | Triazole antifungal agents |
US4973750A (en) * | 1984-09-19 | 1990-11-27 | Schering Corporation | Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
US4582918A (en) * | 1984-09-19 | 1986-04-15 | Schering Corporation | Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
US5124525A (en) * | 1991-08-27 | 1992-06-23 | Esab Welding Products, Inc. | Plasma arc torch having improved nozzle assembly |
US5352832A (en) * | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
PE20050386A1 (es) * | 2003-05-29 | 2005-06-23 | Schering Plough Ltd | Composiciones farmaceuticas de florfenicol |
US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
US20050049210A1 (en) * | 2003-08-27 | 2005-03-03 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
US7126005B2 (en) | 2003-10-06 | 2006-10-24 | Aurobindo Pharma Limited | Process for preparing florfenicol |
EP1776109B1 (en) * | 2004-08-13 | 2008-12-31 | Schering-Plough Ltd. | Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid |
JP4644254B2 (ja) | 2004-09-23 | 2011-03-02 | シェーリング−プラウ・リミテッド | 新規トリフルオロメタンスルホンアニリドオキシムエーテル誘導体の使用による動物における寄生虫の制御 |
WO2006055565A2 (en) * | 2004-11-19 | 2006-05-26 | Schering-Plough Ltd. | Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives |
DK1830885T3 (da) * | 2004-12-21 | 2009-01-05 | Intervet Int Bv | Injicerbar veterinærmedicinsk sammensætning omfattende florfenicol |
WO2007084144A2 (en) * | 2005-01-31 | 2007-07-26 | Materials & Electrochemical Research Corp. | Process for the manufacture of titanium alloy structures |
AR054380A1 (es) * | 2005-06-09 | 2007-06-20 | Schering Plough Ltd | Control de parasitos en animales con derivados de n- ((feniloxi) fenil) -1,1,1-trifluorometansulfonamida y de n-(fenilsulfanil) fenil) -1,1,1-trifluorometansulfonamida |
US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
US20070238700A1 (en) * | 2006-04-10 | 2007-10-11 | Winzenberg Kevin N | N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites |
US8084643B2 (en) * | 2006-12-13 | 2011-12-27 | Intervet Inc. | Water-soluble prodrugs of florfenicol and its analogs |
EP2101750A2 (en) * | 2006-12-13 | 2009-09-23 | Schering-Plough Ltd. | Water-soluble phenicol prodrugs in a lipophilic vehicle system |
CA2672795A1 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
PE20090234A1 (es) * | 2007-04-27 | 2009-04-02 | Schering Plough Ltd | Composiciones farmaceuticas que comprenden florfenicol y ciclodextrinas |
US7550625B2 (en) * | 2007-10-19 | 2009-06-23 | Idexx Laboratories | Esters of florfenicol |
CN101909600A (zh) * | 2007-11-09 | 2010-12-08 | 英特维特国际股份有限公司 | 速释固体制剂、其制备及其应用 |
TWI401023B (zh) | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
JP2011529895A (ja) * | 2008-07-30 | 2011-12-15 | インターベツト・インターナシヨナル・ベー・ベー | フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法 |
UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
UA107804C2 (en) | 2009-08-05 | 2015-02-25 | Du Pont | Mixtures of pesticides mezoionnyh |
EP2461684A2 (en) | 2009-08-05 | 2012-06-13 | E. I. du Pont de Nemours and Company | Mesoionic pesticides |
JP2013501063A (ja) | 2009-08-05 | 2013-01-10 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | メソイオン性殺虫剤 |
BRPI1002023A2 (pt) | 2010-03-01 | 2011-10-25 | Nanocore Biotecnologia S A | forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas |
KR102060464B1 (ko) | 2010-05-27 | 2019-12-30 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 4-[5-[3-클로로-5-(트라이플루오로메틸)페닐]-4,5-다이하이드로-5-(트라이플루오로메틸)-3-아이속사졸릴]-n-[2-옥소-2-[(2,2,2-트라이플루오로에틸)아미노]에틸]-1-나프탈렌카르복스아미드의 결정 형태 |
WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
AU2012251438A1 (en) | 2011-05-02 | 2013-11-14 | Pfizer Inc. | Novel cephalosporins useful as antibacterial agents |
WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
CN110903257A (zh) * | 2019-12-18 | 2020-03-24 | 厦门本素药业有限公司 | 一种苯基异丝氨酸盐酸盐及其中间体的合成方法 |
CN111393341A (zh) * | 2020-05-07 | 2020-07-10 | 中国农业大学 | 一种水溶性氟苯尼考氨基酸盐的制备方法 |
CN115634202A (zh) * | 2022-10-19 | 2023-01-24 | 湖南中科汇智信息服务有限公司 | 一种水溶性氟苯尼考粉及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3012073A (en) * | 1960-04-11 | 1961-12-05 | Du Pont | Trifluoro methylthiophenyl-dichloro-acet-amides-1, 3-propanediol |
-
1980
- 1980-01-31 ES ES80488154A patent/ES8104203A1/es not_active Expired
- 1980-04-04 US US06/137,160 patent/US4311857A/en not_active Expired - Lifetime
- 1980-08-29 ES ES494632A patent/ES494632A0/es active Granted
- 1980-08-29 ES ES494633A patent/ES494633A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ES8107162A1 (es) | 1981-08-16 |
ES494632A0 (es) | 1981-08-16 |
ES488154A0 (es) | 1981-04-16 |
ES8107163A1 (es) | 1981-08-16 |
US4311857A (en) | 1982-01-19 |
ES494633A0 (es) | 1981-08-16 |
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