ES8107163A1 - Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol - Google Patents

Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol

Info

Publication number
ES8107163A1
ES8107163A1 ES494633A ES494633A ES8107163A1 ES 8107163 A1 ES8107163 A1 ES 8107163A1 ES 494633 A ES494633 A ES 494633A ES 494633 A ES494633 A ES 494633A ES 8107163 A1 ES8107163 A1 ES 8107163A1
Authority
ES
Spain
Prior art keywords
methods
acylamido
fluoro
aryl
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494633A
Other languages
English (en)
Other versions
ES494633A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/009,207 external-priority patent/US4235892A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES8107163A1 publication Critical patent/ES8107163A1/es
Publication of ES494633A0 publication Critical patent/ES494633A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPUESTOS D-(TREO)-1-ARIL-2-ACILAMIDO-3-FLUOR-1-PROPANOL. CONSISTE EN TRATAR EL PRODUCTO INICIAL DE FORMULA GENERAL (I) CON UNA O AMBAS POSICIONES PARA Y META DE LA POSICION FENILICA OCUPADA POR UN SUSTITUYENTE X", PARA EFECTUAR SU CONVERSION EN X O X'' (LOS CUALES REPRESENTAN UN ATOMO DE HDIROGENO, O HALOGENO, UN GRUPO NITRO, CIANO O FENILO. A CONTINUACION, Y OPCIONALMENTE, SE DEUTERA EL COMPUESTO OBTENIDO; SE ESTERIFICA O HIDROLIZA LA FUNCION 2-HIDROXILICA, O BIEN SE OBTIENE LA SAL FARMACEUTICAMENTE ACEPTABLE. LA ESTERIFICACION SE EFECTUA CON UN AMINOACIDO TAL COMO GLICINA O UN DERIVADO DE LA MISMA. *FORMULA*
ES494633A 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol Granted ES494633A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/009,207 US4235892A (en) 1979-02-05 1979-02-05 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
ZA00800478A ZA80478B (en) 1979-02-05 1980-01-28 Novel 1-aryl-2-acylamido-3-fluoro-1-propanols,their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES8107163A1 true ES8107163A1 (es) 1981-08-16
ES494633A0 ES494633A0 (es) 1981-08-16

Family

ID=26679196

Family Applications (3)

Application Number Title Priority Date Filing Date
ES80488154A Expired ES8104203A1 (es) 1979-02-05 1980-01-31 Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
ES494632A Granted ES494632A0 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol
ES494633A Granted ES494633A0 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d(treo)-1-aril-2-acilamido-3-fluor-1-propanol

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES80488154A Expired ES8104203A1 (es) 1979-02-05 1980-01-31 Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
ES494632A Granted ES494632A0 (es) 1979-02-05 1980-08-29 Un procedimiento para la preparacion de un compuesto d- (treo)-1-aril-2-acilamido-3-fluor-1-propanol

Country Status (2)

Country Link
US (1) US4311857A (es)
ES (3) ES8104203A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8322983D0 (en) * 1983-08-26 1983-09-28 Pfizer Ltd Triazole antifungal agents
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5124525A (en) * 1991-08-27 1992-06-23 Esab Welding Products, Inc. Plasma arc torch having improved nozzle assembly
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
TW200505425A (en) * 2003-05-29 2005-02-16 Schering Plough Ltd Compositions and method for treating infection in cattle and swine
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
AU2005272925B2 (en) * 2004-08-13 2011-02-10 Intervet International B.V. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
EP1799636B1 (en) 2004-09-23 2008-08-27 Schering-Plough Ltd. Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
US7705038B2 (en) * 2004-11-19 2010-04-27 Intervet, Inc. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives
PL1830885T3 (pl) * 2004-12-21 2009-04-30 Intervet Int Bv Iniekcyjna kompozycja weterynaryjna zawierająca florfenikol
WO2007084144A2 (en) * 2005-01-31 2007-07-26 Materials & Electrochemical Research Corp. Process for the manufacture of titanium alloy structures
CA2609574A1 (en) * 2005-06-09 2006-12-21 Schering-Plough Ltd. Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
MX2009006467A (es) * 2006-12-13 2009-08-21 Schering Plough Ltd Profarmacos solubles en agua de cloranfenicol, tiamfenicol y analogos de los mismos.
WO2008076259A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
MX2009006468A (es) * 2006-12-13 2009-08-20 Schering Plough Ltd Profarmacos de fenicol solubles en agua en un sistema de vehiculo lipofilico.
CA2685264A1 (en) * 2007-04-27 2008-11-06 Schering-Plough Ltd. Compounds and methods for enhancing solubility of florfenicol and structurally-related antibiotics using cyclodextrins
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
BRPI0818906A2 (pt) * 2007-11-09 2015-05-12 Intervet Int Bv Formulação sólida de liberação rápida, preparação e uso da mesma
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
JP2013501059A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
MX2012001646A (es) 2009-08-05 2012-03-21 Du Pont Pesticidas mesoionicos.
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
CA2799963C (en) 2010-05-27 2018-01-23 E. I. Du Pont De Nemours And Company Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4,5 -dihydro-5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [(2,2,2-trifluoroethyl)amino]ethyl] -1-naphthalenecarboxamide
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CA2834999A1 (en) 2011-05-02 2012-11-08 Zoetis Llc Novel cephalosporins useful as antibacterial agents
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN110903257A (zh) * 2019-12-18 2020-03-24 厦门本素药业有限公司 一种苯基异丝氨酸盐酸盐及其中间体的合成方法
CN111393341A (zh) * 2020-05-07 2020-07-10 中国农业大学 一种水溶性氟苯尼考氨基酸盐的制备方法
CN115634202A (zh) * 2022-10-19 2023-01-24 湖南中科汇智信息服务有限公司 一种水溶性氟苯尼考粉及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012073A (en) * 1960-04-11 1961-12-05 Du Pont Trifluoro methylthiophenyl-dichloro-acet-amides-1, 3-propanediol

Also Published As

Publication number Publication date
ES8107162A1 (es) 1981-08-16
ES488154A0 (es) 1981-04-16
ES494633A0 (es) 1981-08-16
ES8104203A1 (es) 1981-04-16
US4311857A (en) 1982-01-19
ES494632A0 (es) 1981-08-16

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