CA1129794A - Agent antihypercholesterolemique monacoline k, et sa preparation - Google Patents
Agent antihypercholesterolemique monacoline k, et sa preparationInfo
- Publication number
- CA1129794A CA1129794A CA345,983A CA345983A CA1129794A CA 1129794 A CA1129794 A CA 1129794A CA 345983 A CA345983 A CA 345983A CA 1129794 A CA1129794 A CA 1129794A
- Authority
- CA
- Canada
- Prior art keywords
- monacolin
- monascus
- culture medium
- strain
- antihypercholesteraemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54017856A JPS5925599B2 (ja) | 1979-02-20 | 1979-02-20 | 新生理活性物質モナコリンkおよびその製造法 |
JP17856/79 | 1979-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1129794A true CA1129794A (fr) | 1982-08-17 |
Family
ID=11955290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA345,983A Expired CA1129794A (fr) | 1979-02-20 | 1980-02-19 | Agent antihypercholesterolemique monacoline k, et sa preparation |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5925599B2 (fr) |
KR (1) | KR830002801B1 (fr) |
AT (1) | AT373915B (fr) |
AU (1) | AU532626B2 (fr) |
BE (1) | BE881825A (fr) |
CA (1) | CA1129794A (fr) |
CH (1) | CH645890A5 (fr) |
DD (1) | DD154494A5 (fr) |
DE (2) | DE3006216C2 (fr) |
DK (2) | DK149095C (fr) |
ES (1) | ES488796A0 (fr) |
FI (1) | FI66427C (fr) |
FR (1) | FR2449685B1 (fr) |
GB (1) | GB2046737B (fr) |
HU (1) | HU182069B (fr) |
IE (1) | IE49743B1 (fr) |
IT (1) | IT1175260B (fr) |
MX (1) | MX6314E (fr) |
NL (1) | NL191540C (fr) |
NO (1) | NO153974C (fr) |
NZ (1) | NZ192919A (fr) |
PH (1) | PH15145A (fr) |
PL (1) | PL124304B1 (fr) |
SE (1) | SE453301B (fr) |
SG (1) | SG6784G (fr) |
SU (2) | SU1158048A3 (fr) |
ZA (1) | ZA80962B (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362638A (en) * | 1992-02-10 | 1994-11-08 | Dahiya Jagroop S | Fungal strains and use thereof in antibiotic production |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
EP0629184A1 (fr) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | DERIVES DE TETRALINE EN TANT QU'INHIBITEURS D'HMG-CoA REDUCTASE |
NZ247617A (en) | 1992-05-15 | 1995-07-26 | Sankyo Co | Octahydronaphthalene oxime derivatives and pharmaceutical compositions |
US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
CZ300153B6 (cs) | 1998-03-20 | 2009-02-25 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Metabolicky kontrolovaný proces fermentace pri výrobe lovastatinové hydroxykyseliny |
JP3740062B2 (ja) | 2000-02-24 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | 培養液の精製方法 |
PL357533A1 (en) | 2000-03-03 | 2004-07-26 | Plus Chemicals, S.A. | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
KR20010095780A (ko) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | 배아 홍국 |
IN192861B (fr) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
AU2002235885A1 (en) | 2001-02-09 | 2002-08-28 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
KR20020093147A (ko) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | 성인병 예방 및 치료 보조제 |
KR100710500B1 (ko) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 k 생산방법 |
EP2327682A1 (fr) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines. |
WO2010069593A1 (fr) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Utilisation de composés amphiphiles pour la cristallisation régulée de statines et d'intermédiaires de statines |
RO128803A0 (ro) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Compoziţie pentru tratamentul sau prevenirea dislipidemiilor |
CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
CN111297938A (zh) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | 一种辅助降血脂组合物中洛伐他汀的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (fr) | 1974-06-07 | 1981-03-18 | ||
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
GR69216B (fr) * | 1979-06-15 | 1982-05-07 | Merck & Co Inc |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/ja not_active Expired
-
1980
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/ko active
- 1980-02-19 CA CA345,983A patent/CA1129794A/fr not_active Expired
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-20 DE DE3006216A patent/DE3006216C2/de not_active Expired
- 1980-02-20 CH CH136680A patent/CH645890A5/de not_active IP Right Cessation
- 1980-02-20 AT AT0092980A patent/AT373915B/de not_active IP Right Cessation
- 1980-02-20 ES ES488796A patent/ES488796A0/es active Granted
- 1980-02-20 DD DD80219159A patent/DD154494A5/de unknown
- 1980-02-20 MX MX808652U patent/MX6314E/es unknown
- 1980-02-20 FR FR8003662A patent/FR2449685B1/fr not_active Expired
- 1980-02-20 FI FI800506A patent/FI66427C/fi not_active IP Right Cessation
- 1980-02-20 DK DK73080A patent/DK149095C/da not_active IP Right Cessation
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/xx unknown
- 1980-02-20 BE BE0/199476A patent/BE881825A/fr not_active IP Right Cessation
- 1980-02-20 HU HU80397A patent/HU182069B/hu unknown
- 1980-02-20 PL PL1980222120A patent/PL124304B1/pl unknown
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 NO NO800451A patent/NO153974C/no unknown
- 1980-02-20 SU SU802887300A patent/SU1158048A3/ru active
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 SE SE8001339A patent/SE453301B/sv not_active IP Right Cessation
- 1980-02-20 NL NL8001041A patent/NL191540C/xx not_active IP Right Cessation
- 1980-02-20 IT IT67262/80A patent/IT1175260B/it active
- 1980-09-12 SU SU802977031A patent/SU969702A1/ru active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889D0/da not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362638A (en) * | 1992-02-10 | 1994-11-08 | Dahiya Jagroop S | Fungal strains and use thereof in antibiotic production |
LT3083B (en) | 1992-02-10 | 1994-11-25 | Novopharm Ltd | Novel fungal strains and use thereof in antibiotic production |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1129794A (fr) | Agent antihypercholesterolemique monacoline k, et sa preparation | |
US4323648A (en) | Preparation of Monacolin K | |
US4024246A (en) | Antibiotic A-22082 and process for production thereof | |
US5756472A (en) | Antifungal agent obtained from hormonema | |
NZ194445A (en) | Monacolin k salts and esters | |
US4952604A (en) | Antifungal agent | |
US5276055A (en) | Antibiotic agents | |
GB2111989A (en) | New compounds having cholesterol-reducing activity | |
EP0877618B1 (fr) | Agent antifongique | |
JP3026864B2 (ja) | 新規セスキテルペン誘導体 | |
US5008187A (en) | Antifungal fermentation product | |
CA1191467A (fr) | A-32724 antibiotique et procede de production | |
US5304485A (en) | Antibiotic producing microorganism | |
AU1132000A (en) | Microbial transformation product | |
US5441987A (en) | Antifungal agent | |
US5712109A (en) | Antifungal agent produced by arthrinium arundinis ATCC 74359 | |
JPS6113798B2 (fr) | ||
DK165990B (da) | Fremgangsmaade til fremstilling af carboxylsyren af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k eller salte deraf | |
JPH04368378A (ja) | フサリウム種からの新規代謝産物アジスタチン類、その製造方法およびその使用 | |
GB2306474A (en) | Antifungal agent | |
JPS6210998B2 (fr) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |