BRPI0715888A2 - composto ou sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para produzir um efeito inibitàrio de mtor e um efeito anti-cÂncer em um animal de sangue quente e para tratar doenÇas em um animal de sangue quente - Google Patents

composto ou sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para produzir um efeito inibitàrio de mtor e um efeito anti-cÂncer em um animal de sangue quente e para tratar doenÇas em um animal de sangue quente

Info

Publication number
BRPI0715888A2
BRPI0715888A2 BRPI0715888-2A2A BRPI0715888A BRPI0715888A2 BR PI0715888 A2 BRPI0715888 A2 BR PI0715888A2 BR PI0715888 A BRPI0715888 A BR PI0715888A BR PI0715888 A2 BRPI0715888 A2 BR PI0715888A2
Authority
BR
Brazil
Prior art keywords
warm
cancer
blooded animal
compound
effect
Prior art date
Application number
BRPI0715888-2A2A
Other languages
English (en)
Inventor
Heather Mary Ellen Duggan
Frederic Georges Marie Leroux
Karine Malagu
Niall Morrisson Barr Martin
Keith Allan Menear
Graeme Cameron Murray Smith
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38537521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0715888(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of BRPI0715888A2 publication Critical patent/BRPI0715888A2/pt
Publication of BRPI0715888A8 publication Critical patent/BRPI0715888A8/pt
Publication of BRPI0715888B1 publication Critical patent/BRPI0715888B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0715888-2A 2006-08-23 2007-08-21 Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto BRPI0715888B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82331106P 2006-08-23 2006-08-23
US60/823,311 2006-08-23
US93877607P 2007-05-18 2007-05-18
US60/938,776 2007-05-18
PCT/GB2007/003179 WO2008023161A1 (en) 2006-08-23 2007-08-21 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors

Publications (3)

Publication Number Publication Date
BRPI0715888A2 true BRPI0715888A2 (pt) 2013-09-17
BRPI0715888A8 BRPI0715888A8 (pt) 2018-04-17
BRPI0715888B1 BRPI0715888B1 (pt) 2021-11-03

Family

ID=38537521

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0715888-2A BRPI0715888B1 (pt) 2006-08-23 2007-08-21 Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto

Country Status (29)

Country Link
US (6) US7902189B2 (pt)
EP (1) EP2057156B1 (pt)
JP (2) JP5227321B2 (pt)
KR (1) KR101438245B1 (pt)
AR (1) AR062503A1 (pt)
AU (1) AU2007287430B2 (pt)
BR (1) BRPI0715888B1 (pt)
CA (1) CA2659851C (pt)
CL (1) CL2007002448A1 (pt)
CO (1) CO6150164A2 (pt)
CY (1) CY1119381T1 (pt)
DK (1) DK2057156T3 (pt)
ES (1) ES2648388T3 (pt)
HR (1) HRP20170627T1 (pt)
HU (1) HUE033894T2 (pt)
IL (1) IL196775A (pt)
LT (1) LT2057156T (pt)
MX (1) MX2009001946A (pt)
MY (1) MY148688A (pt)
NO (1) NO342383B1 (pt)
NZ (1) NZ575672A (pt)
PL (1) PL2057156T3 (pt)
PT (1) PT2057156T (pt)
RS (1) RS55881B1 (pt)
RU (1) RU2445312C2 (pt)
SA (1) SA07280461B1 (pt)
SI (1) SI2057156T1 (pt)
TW (1) TWI406863B (pt)
WO (1) WO2008023161A1 (pt)

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US9717736B2 (en) 2017-08-01
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IL196775A (en) 2017-05-29
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