BRPI0713153B8 - tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo - Google Patents

tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Info

Publication number
BRPI0713153B8
BRPI0713153B8 BRPI0713153A BRPI0713153A BRPI0713153B8 BR PI0713153 B8 BRPI0713153 B8 BR PI0713153B8 BR PI0713153 A BRPI0713153 A BR PI0713153A BR PI0713153 A BRPI0713153 A BR PI0713153A BR PI0713153 B8 BRPI0713153 B8 BR PI0713153B8
Authority
BR
Brazil
Prior art keywords
seq
tetrapeptide
production
inducing
composition
Prior art date
Application number
BRPI0713153A
Other languages
English (en)
Portuguese (pt)
Inventor
Zhang Lijuan
M Harris Scott
J Falla Timothy
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Priority to BR122018002612A priority Critical patent/BR122018002612B8/pt
Publication of BRPI0713153A2 publication Critical patent/BRPI0713153A2/pt
Publication of BRPI0713153B1 publication Critical patent/BRPI0713153B1/pt
Publication of BRPI0713153B8 publication Critical patent/BRPI0713153B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
BRPI0713153A 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo BRPI0713153B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122018002612A BR122018002612B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81328406P 2006-06-13 2006-06-13
US60/813.284 2006-06-13
PCT/US2007/013748 WO2007146269A2 (en) 2006-06-13 2007-06-12 Peptide fragments for inducing synthesis of extracellular matrix proteins

Publications (3)

Publication Number Publication Date
BRPI0713153A2 BRPI0713153A2 (pt) 2012-03-27
BRPI0713153B1 BRPI0713153B1 (pt) 2019-05-14
BRPI0713153B8 true BRPI0713153B8 (pt) 2021-05-25

Family

ID=38664422

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0713153A BRPI0713153B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo
BR122018002612A BR122018002612B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122018002612A BR122018002612B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Country Status (19)

Country Link
US (5) US8110658B2 (enExample)
EP (5) EP2940042A3 (enExample)
JP (2) JP5535620B2 (enExample)
CN (2) CN104017071B (enExample)
AT (1) ATE533785T1 (enExample)
AU (1) AU2007258387B2 (enExample)
BR (2) BRPI0713153B8 (enExample)
CA (4) CA2947353A1 (enExample)
CY (1) CY1112241T1 (enExample)
DK (3) DK2409988T3 (enExample)
ES (4) ES2680022T3 (enExample)
HK (1) HK1210791A1 (enExample)
HU (2) HUE026698T2 (enExample)
MX (2) MX2008016011A (enExample)
PL (4) PL2409988T3 (enExample)
PT (2) PT2402369E (enExample)
RU (2) RU2501807C2 (enExample)
SI (2) SI2409988T1 (enExample)
WO (1) WO2007146269A2 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2680022T3 (es) * 2006-06-13 2018-09-03 Helix Biomedix Inc. Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular
EP2065029B1 (en) * 2007-11-30 2013-04-17 Evonik Goldschmidt GmbH Personal care and cosmetic composition containing tetrapeptides with the motifs GX1X2G, PX1X2P, or PX1X2K
WO2009111471A2 (en) * 2008-03-03 2009-09-11 Henry Ford Health System Collagen-derived peptide as biomarker, therapeutic agent and target
CA2753224C (en) * 2008-12-30 2018-04-17 Gkl-Biotec Ag Peptide combination
WO2011044443A2 (en) 2009-10-09 2011-04-14 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Matricryptic ecm peptides for tissue reconstruction
US8969290B2 (en) 2012-06-26 2015-03-03 Worcester Polytechnic Institute Matrix scaffold with antimicrobial activity
NZ711281A (en) * 2013-02-14 2017-12-22 Helix Biomedix Inc Short bio-active peptides for promoting wound healing
CA2902938C (en) 2013-03-13 2021-06-01 Neocutis Sa Peptides for skin rejuvenation and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
RU2687151C2 (ru) * 2013-06-14 2019-05-07 Хеликс Биомедикс Инк. Тетрапептиды, полученные из с-х-с-хемокинов человека, подходящие для лечения различных состояний кожи
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
WO2017024182A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
KR101916522B1 (ko) 2015-09-25 2018-11-08 경상대학교산학협력단 굴 가수분해물의 제조방법 및 이로부터 분리된 펩타이드
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
RU2019110848A (ru) * 2016-09-14 2020-10-15 Дьюк Юниверсити Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
JP6489486B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 ペンタペプチド／ヘキサペプチドにより変形性関節症を治療するための新規用途
JP6489487B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 テトラペプチド−３ ｇｅｋｇまたはペンタペプチド−３ ｇｅｋｇｆにより変形性関節症を治療するための新規用途
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
US12257308B2 (en) 2018-04-30 2025-03-25 Duke University Stimuli-responsive PEG-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
EP4000596A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000597A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000598A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000595A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4140473A1 (en) * 2021-08-27 2023-03-01 The Boots Company plc Cosmetic compositions
CN115990240A (zh) * 2021-10-20 2023-04-21 富比积生物科技股份有限公司 寡肽在治疗牙龈发炎、牙龈萎缩及修复口腔黏膜中的用途
CN114437238B (zh) * 2022-01-26 2024-03-26 浙江工业大学 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法
CN115894615A (zh) * 2022-10-19 2023-04-04 上海高科生物工程有限公司 一种抗皮肤衰老的五肽衍生肽段ys及其应用
CN116375847B (zh) * 2022-10-26 2025-06-13 江苏创健医疗科技股份有限公司 酵母重组xvii型人源化胶原蛋白及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU466760B2 (en) * 1972-03-14 1975-11-06 Takeda Chemical Industries Ltd. Process for producing peptide
US5064430A (en) * 1985-10-31 1991-11-12 Uab Research Foundation Polynonapeptide bioelastomers having an increased elastic modulus
JP2573006B2 (ja) * 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
DE68918388T2 (de) 1988-04-21 1995-03-02 Uab Research Foundation Bioelastomer ohne adhäsionseigenschaft zum einsatz am wundort.
ATE189231T1 (de) 1989-04-10 2000-02-15 Helix Biomedix Inc Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs
US5679770A (en) * 1991-11-08 1997-10-21 Mochida Pharmaceutical Co., Ltd. Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
JP3100005B2 (ja) * 1992-07-28 2000-10-16 雪印乳業株式会社 ヒト免疫不全ウィルス感染・増殖抑制剤
US6132976A (en) * 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
IL104954A (en) * 1993-03-04 2006-08-01 Yissum Res Dev Co Use of osteogenic oligopeptides in the preparation of pharmaceutical compositions for the treatment of bone diseases and some such novel oligopeptides, pharmaceutical compositions containing them and their preparation
US5561107A (en) 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
JPH07227281A (ja) * 1994-02-15 1995-08-29 Agency Of Ind Science & Technol ペプチダーゼ及びその製造法
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
US6159940A (en) * 1996-02-28 2000-12-12 Immunotech Developments Inc. Method for modulating hemopoiesis
DE19651099A1 (de) * 1996-12-09 1998-06-10 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
EP1074620A1 (en) * 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
EP0858808B1 (en) * 1997-01-17 2003-04-02 Johnson & Johnson Medical Ltd. Peptides for use in wound treatment
US6639050B1 (en) * 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
GB2341182A (en) * 1998-09-01 2000-03-08 Yamanouchi Uk Ltd Protein comprising amino acid sequences having SH3 domain binding activity and nuclear localisation activity
US6747135B1 (en) * 1998-10-16 2004-06-08 The Board Of Trustees For The Leland Stanford Junior University Fluorescent dye binding peptides
US6492326B1 (en) * 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
CA2276542C (en) 1999-06-28 2013-07-30 Vladislav I. Deigin Novel peptide, a method for its preparation and a pharmaceutical composition containing the peptide
CN1280983A (zh) * 1999-07-16 2001-01-24 王革 白细胞介素－11的衍生物及其制备方法
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
WO2001079561A2 (en) * 2000-04-17 2001-10-25 Liggett Stephen B Alpha-2 adrenergic receptor polymorphisms
US20030166510A1 (en) * 2000-10-11 2003-09-04 Pickart Loren R. Methods and compositions for increasing skin remodeling
GB0029777D0 (en) * 2000-12-06 2001-01-17 Regen Therapeutics Plc Peptides
EP2105141B1 (en) 2001-03-28 2012-08-08 Helix Biomedix, Inc. Short bioactive peptides and methods for their use
US7186693B2 (en) * 2001-08-16 2007-03-06 Kimberly - Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing
US7041506B2 (en) * 2001-11-19 2006-05-09 Becton Dickinson And Company Peptides promoting cell adherence, growth and secretion
JP2005519587A (ja) * 2001-11-28 2005-07-07 ベクトン・ディキンソン・アンド・カンパニー 増殖阻害作用を有するペプチド
US20040009911A1 (en) * 2002-01-31 2004-01-15 Irm, Llc Hepsin substrates and prodrugs
WO2003093314A2 (en) * 2002-05-03 2003-11-13 Millenium Biologix Inc. Connective tissue stimulating peptides
DE60332158D1 (de) * 2002-09-09 2010-05-27 Univ Cincinnati Verfahren zur herzerkrankungsbewertung in einer einzelperson
US7541440B2 (en) * 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
TWI256893B (en) * 2003-03-25 2006-06-21 Fancl Corp Composition for promoting production of type I collagen and/or elastin
DE10339180A1 (de) * 2003-08-21 2005-03-24 Deutsche Gelatine-Fabriken Stoess Ag Kollagenhydrolysat
US7638318B2 (en) 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
KR101045658B1 (ko) 2003-11-17 2011-07-01 쎄데르마 테트라펩티드 및 트리펩티드 혼합물을 포함하는 조성물
JP2005245285A (ja) * 2004-03-03 2005-09-15 National Institute Of Advanced Industrial & Technology コラーゲン分解物の製造方法
DE102004055541A1 (de) * 2004-11-17 2006-05-18 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut
DE102004050563A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Kosmetische und der dermatologische Zusammensetzungen mit Wirkstoffen für einen verbesserten Hautkomfort
DE102005000868A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Zusammensetzungen mit Inhibitoren der Prostaglandin- und/oder Leukotrien-Synthese in Kombination mit Stimulatoren der Freisetzung kutaner Neuromediatoren
DE202004012807U1 (de) * 2004-08-13 2004-10-21 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen mit DNA-Reparaturenzymen und Oligopeptiden
US20060046271A1 (en) * 2004-09-02 2006-03-02 Vanderbilt University Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides
CA2583113C (en) * 2004-10-05 2015-11-10 Diversa Corporation Compositions comprising an antigen and a promiscuous t-cell epitope
WO2006042661A2 (en) * 2004-10-18 2006-04-27 Cognis France S.A.S Oligopeptides and their use in cosmetics
WO2006048339A2 (en) * 2004-11-04 2006-05-11 L'oréal Cosmetic composition comrising an active agent and a urea compound
US20070224150A1 (en) * 2005-03-24 2007-09-27 Yongji Chung Growth factor for hair and skin treatment
FR2884418B1 (fr) * 2005-04-15 2008-11-21 Soc Extraction Principes Actif Utilisation d'un peptide comme principe actif amincissant
AU2006266609C1 (en) * 2005-07-05 2011-10-27 Biotempt B.V. Treatment of tumors
DE102005063062A1 (de) * 2005-12-29 2007-07-05 Henkel Kgaa Synergistische Proteinhydrolysat-Kombinationen zur Behandlung reifer Haut
US7807625B2 (en) * 2006-01-18 2010-10-05 Grant Industries, Inc Anti-wrinkle composition
ES2680022T3 (es) * 2006-06-13 2018-09-03 Helix Biomedix Inc. Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular

Also Published As

Publication number Publication date
HUE027273T2 (en) 2016-10-28
CN104017071B (zh) 2017-08-15
JP5535620B2 (ja) 2014-07-02
CA2835369A1 (en) 2007-12-21
EP2409988A3 (en) 2012-05-09
EP2409988A2 (en) 2012-01-25
HK1217346A1 (en) 2017-01-06
EP2027152B1 (en) 2011-11-16
WO2007146269A2 (en) 2007-12-21
DK2402369T3 (en) 2016-02-01
EP3002294A2 (en) 2016-04-06
RU2441877C2 (ru) 2012-02-10
DK2409988T3 (en) 2015-09-14
ES2680022T3 (es) 2018-09-03
BRPI0713153A2 (pt) 2012-03-27
BRPI0713153B1 (pt) 2019-05-14
PL3002294T3 (pl) 2018-08-31
RU2009100884A (ru) 2010-07-20
ES2375413T3 (es) 2012-02-29
US8962798B2 (en) 2015-02-24
PL2027152T3 (pl) 2012-04-30
CA2947353A1 (en) 2007-12-21
AU2007258387A1 (en) 2007-12-21
US20120093740A1 (en) 2012-04-19
ES2557402T3 (es) 2016-01-25
CA2835369C (en) 2017-01-31
HK1161599A1 (en) 2012-07-27
CN104017071A (zh) 2014-09-03
JP2014129369A (ja) 2014-07-10
CA2947349A1 (en) 2007-12-21
US20150094270A1 (en) 2015-04-02
CN101472944B (zh) 2014-05-28
HUE026698T2 (en) 2016-07-28
EP3002294A3 (en) 2016-06-22
EP2402369A2 (en) 2012-01-04
US20170157196A1 (en) 2017-06-08
HK1128700A1 (en) 2009-11-06
JP2009539987A (ja) 2009-11-19
HK1161600A1 (en) 2012-07-27
SI2027152T1 (sl) 2012-03-30
HK1210791A1 (en) 2016-05-06
PT2409988E (pt) 2015-10-12
AU2007258387B2 (en) 2012-08-16
CA2655116C (en) 2016-12-13
JP5844834B2 (ja) 2016-01-20
BR122018002612B8 (pt) 2021-07-27
EP2940042A3 (en) 2016-02-17
RU2011141572A (ru) 2013-04-20
EP2402369A3 (en) 2012-05-16
US20070299015A1 (en) 2007-12-27
BR122018002612B1 (pt) 2021-01-19
RU2501807C2 (ru) 2013-12-20
WO2007146269A3 (en) 2008-08-14
US8110658B2 (en) 2012-02-07
CA2655116A1 (en) 2007-12-21
ES2545219T3 (es) 2015-09-09
SI2409988T1 (sl) 2015-10-30
AU2007258387A2 (en) 2009-02-19
EP2409988B1 (en) 2015-07-22
US9447143B2 (en) 2016-09-20
EP2402369B1 (en) 2015-11-25
EP3002294B1 (en) 2018-03-28
DK2027152T3 (da) 2012-02-20
PL2402369T3 (pl) 2016-05-31
EP2940042A2 (en) 2015-11-04
EP2027152A2 (en) 2009-02-25
EP3002294B8 (en) 2018-05-16
CY1112241T1 (el) 2015-12-09
US10376557B2 (en) 2019-08-13
US20140066380A1 (en) 2014-03-06
ATE533785T1 (de) 2011-12-15
PT2402369E (pt) 2016-02-19
US8658764B2 (en) 2014-02-25
MX361694B (es) 2018-12-10
PL2409988T3 (pl) 2015-12-31
MX2008016011A (es) 2009-02-13
CN101472944A (zh) 2009-07-01

Similar Documents

Publication Publication Date Title
BRPI0713153B8 (pt) tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo
IL163970A0 (en) Dedifferentiated, programmable stemcells of monocytic origin, and their production and use
WO2010123945A3 (en) Silk fibroin hydrogels and uses thereof
ECSP099332A (es) Moléculas de enlace de lingo y uso farmacéutico de las mismas
CR7718A (es) Nuevos derivados de glicosido de tiofeno, metodos para la preparacion de los mismos, medicamentos que comprenden dichos compuestos, y su uso
ECSP066355A (es) Compuestos de 2-(quinoxalin-5-ilsulfonilamino)-benzamida como moduladores de la colecistocinina 2
MY148096A (en) 4,5-diphenyl-pyrimidinyl-amino substituted carboxylic acids, method for the production and use thereof as medicaments
MY158100A (en) 6,9-disubstituted purine derivatives and their use for treating skin
EP2061527B8 (en) Repair of cartilage tissue
ES2178779T3 (es) Nuevas amidas de acidos de piridil alcanos como agentes citoestaticos e inmunosupresores.
CU20130063A7 (es) Proceso de producción de depsipéptidos cíclicos
CL2012001380A1 (es) Composición farmacéutica o cosmética que comprende el polipéptido coriolisina l, las proteínas muy ácidas vapi, vapii, vapiii, y una o más moléculas de ácido nucleico que codifican cualquiera de los polipéptidos recién mencionados; ácido nucleico; vector, célula hospedera; método de preparación de dichos polipéptidos; y método cosmético para exfoliar y/o humectar la piel de un animal.
AR069584A1 (es) Proteinas de elastasa recombinantes y sus metodos de preparacion y su uso
JO2229B1 (en) Stem cells are programmable, distinctly regenerative, of single-core cell origin, production, and use
BRPI0719885B8 (pt) peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
BR0212070A (pt) ácidos nucléicos e polipeptìdeos bv8 com atividade mitogênica
DK1763363T3 (da) Farmaceutiske præparater indeholdende diaminooxidase
AR059193A1 (es) Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
AR053285A1 (es) Tratamiento de enfemedades usando un sistema mejorado de expresion regulada
WO2010056040A2 (ko) 생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체
ES2188140T3 (es) Utilizacion del factor de crecimiento de monocitos cd137 o un analogo funcional del mismo para producir un medicamento.
ATE544779T1 (de) Neue, die migration dendritischer zellen induzierende polypeptide, sowie medikamente und pharmazeutische zusammensetzungen, die diese enthalten
DOP2006000117A (es) Terapia génica de interferon-beta usando un sistema mejorado de expresión regulada
ATE503838T1 (de) Ortspezifische verabreichung von aktiven substanzen im darm
CY1117084T1 (el) Θραυσματα πεπτιδιου για την επαγωγη συνθεσης πρωτεϊνων εξωκυτταριας μητρας

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/05/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/05/2019, OBSERVADAS AS CONDICOES LEGAIS

B25G Requested change of headquarter approved

Owner name: HELIX BIOMEDIX INC. (US)

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/06/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF