CY1112241T1 - Θραυσματα πεπτιδιου για διεγερση συνθεσης πρωτεϊνων εξωκυτταρικης μητρας - Google Patents

Θραυσματα πεπτιδιου για διεγερση συνθεσης πρωτεϊνων εξωκυτταρικης μητρας

Info

Publication number
CY1112241T1
CY1112241T1 CY20121100042T CY121100042T CY1112241T1 CY 1112241 T1 CY1112241 T1 CY 1112241T1 CY 20121100042 T CY20121100042 T CY 20121100042T CY 121100042 T CY121100042 T CY 121100042T CY 1112241 T1 CY1112241 T1 CY 1112241T1
Authority
CY
Cyprus
Prior art keywords
seq
extracellular matrix
peptide fragments
stimulating protein
matrix synthesis
Prior art date
Application number
CY20121100042T
Other languages
English (en)
Inventor
Scott M Harris
Timothy J Falla
Lijun Zhang
Original Assignee
Helix Biomedix Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc. filed Critical Helix Biomedix Inc.
Publication of CY1112241T1 publication Critical patent/CY1112241T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides

Abstract

Αποκαλύπτονται μικρού μήκους βιολογικώς δραστικά τετραπεπτίδια, τα οποία αποτελούνται από τις αλληλουχίες GxxG και ΡxxΡ, όπου το G (γλυκίνη) και Ρ (προλίνη) διατηρούνται και το x είναι ένα μεταβλητό αμινοξύ. Τα πεπτίδια μπορεί να χρησιμοποιούνται απλά ή σε συνδυασμό για να διεγείρουν παραγωγή πρωτεϊνών εξωκυτταρικής μήτρας στο δέρμα. Αποκαλύπτεται μια ταχεία χαμηλού-κόστους μέθοδος παρασκευής ετερογενών φαρμακοτεχνικών μορφών των τετραπεπτιδίων.
CY20121100042T 2006-06-13 2012-01-16 Θραυσματα πεπτιδιου για διεγερση συνθεσης πρωτεϊνων εξωκυτταρικης μητρας CY1112241T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81328406P 2006-06-13 2006-06-13
EP07796001A EP2027152B1 (en) 2006-06-13 2007-06-12 Peptide fragments for inducing synthesis of extracellular matrix proteins

Publications (1)

Publication Number Publication Date
CY1112241T1 true CY1112241T1 (el) 2015-12-09

Family

ID=38664422

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100042T CY1112241T1 (el) 2006-06-13 2012-01-16 Θραυσματα πεπτιδιου για διεγερση συνθεσης πρωτεϊνων εξωκυτταρικης μητρας

Country Status (19)

Country Link
US (5) US8110658B2 (el)
EP (5) EP2402369B1 (el)
JP (2) JP5535620B2 (el)
CN (2) CN104017071B (el)
AT (1) ATE533785T1 (el)
AU (1) AU2007258387B2 (el)
BR (2) BR122018002612B8 (el)
CA (4) CA2655116C (el)
CY (1) CY1112241T1 (el)
DK (3) DK2027152T3 (el)
ES (4) ES2375413T3 (el)
HK (5) HK1161599A1 (el)
HU (2) HUE027273T2 (el)
MX (2) MX2008016011A (el)
PL (4) PL3002294T3 (el)
PT (2) PT2402369E (el)
RU (2) RU2441877C2 (el)
SI (2) SI2409988T1 (el)
WO (1) WO2007146269A2 (el)

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CN101472944B (zh) 2014-05-28
AU2007258387B2 (en) 2012-08-16
US20140066380A1 (en) 2014-03-06
EP2409988B1 (en) 2015-07-22
PL2027152T3 (pl) 2012-04-30
RU2501807C2 (ru) 2013-12-20
ES2375413T3 (es) 2012-02-29
CN101472944A (zh) 2009-07-01
JP5535620B2 (ja) 2014-07-02
CA2835369C (en) 2017-01-31
EP2402369A3 (en) 2012-05-16
US9447143B2 (en) 2016-09-20
AU2007258387A2 (en) 2009-02-19
PT2402369E (pt) 2016-02-19
HK1161600A1 (zh) 2012-07-27
ES2680022T3 (es) 2018-09-03
US20150094270A1 (en) 2015-04-02
HUE026698T2 (en) 2016-07-28
BRPI0713153B8 (pt) 2021-05-25
US8962798B2 (en) 2015-02-24
EP3002294B8 (en) 2018-05-16
EP2027152B1 (en) 2011-11-16
DK2027152T3 (da) 2012-02-20
RU2011141572A (ru) 2013-04-20
WO2007146269A3 (en) 2008-08-14
CA2947353A1 (en) 2007-12-21
EP2940042A3 (en) 2016-02-17
PL2409988T3 (pl) 2015-12-31
BR122018002612B1 (pt) 2021-01-19
EP2027152A2 (en) 2009-02-25
WO2007146269A2 (en) 2007-12-21
JP2014129369A (ja) 2014-07-10
RU2441877C2 (ru) 2012-02-10
HK1161599A1 (en) 2012-07-27
CN104017071B (zh) 2017-08-15
BRPI0713153A2 (pt) 2012-03-27
DK2402369T3 (en) 2016-02-01
US10376557B2 (en) 2019-08-13
EP2409988A2 (en) 2012-01-25
PT2409988E (pt) 2015-10-12
CA2655116A1 (en) 2007-12-21
AU2007258387A1 (en) 2007-12-21
US20120093740A1 (en) 2012-04-19
EP3002294B1 (en) 2018-03-28
US20070299015A1 (en) 2007-12-27
EP2402369A2 (en) 2012-01-04
SI2409988T1 (sl) 2015-10-30
CA2835369A1 (en) 2007-12-21
DK2409988T3 (en) 2015-09-14
ES2545219T3 (es) 2015-09-09
RU2009100884A (ru) 2010-07-20
BR122018002612B8 (pt) 2021-07-27
EP3002294A2 (en) 2016-04-06
HK1210791A1 (en) 2016-05-06
HUE027273T2 (en) 2016-10-28
HK1128700A1 (en) 2009-11-06
EP2409988A3 (en) 2012-05-09
US20170157196A1 (en) 2017-06-08
ATE533785T1 (de) 2011-12-15
BRPI0713153B1 (pt) 2019-05-14
US8658764B2 (en) 2014-02-25
JP2009539987A (ja) 2009-11-19
SI2027152T1 (sl) 2012-03-30
MX361694B (es) 2018-12-10
HK1217346A1 (zh) 2017-01-06
JP5844834B2 (ja) 2016-01-20
MX2008016011A (es) 2009-02-13
CA2947349A1 (en) 2007-12-21
US8110658B2 (en) 2012-02-07
EP2940042A2 (en) 2015-11-04
EP2402369B1 (en) 2015-11-25
PL3002294T3 (pl) 2018-08-31
ES2557402T3 (es) 2016-01-25
CN104017071A (zh) 2014-09-03
PL2402369T3 (pl) 2016-05-31
CA2655116C (en) 2016-12-13
EP3002294A3 (en) 2016-06-22

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