BR122018002612B8 - tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo - Google Patents

tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Info

Publication number
BR122018002612B8
BR122018002612B8 BR122018002612A BR122018002612A BR122018002612B8 BR 122018002612 B8 BR122018002612 B8 BR 122018002612B8 BR 122018002612 A BR122018002612 A BR 122018002612A BR 122018002612 A BR122018002612 A BR 122018002612A BR 122018002612 B8 BR122018002612 B8 BR 122018002612B8
Authority
BR
Brazil
Prior art keywords
seq
tetrapeptide
production
inducing
composition
Prior art date
Application number
BR122018002612A
Other languages
English (en)
Other versions
BR122018002612B1 (pt
Inventor
Zhang Lijuan
M Harris Scott
J Falla Timothy
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Publication of BR122018002612B1 publication Critical patent/BR122018002612B1/pt
Publication of BR122018002612B8 publication Critical patent/BR122018002612B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

são revelados tetrapeptídeos biologicamente ativos curtos que são compreendidos das seqüências gxxg e pxxp, onde g (glicina) e p (prolina) são mantidas e x é um aminoácido variável. os peptídeos podem ser usados individualmente ou em combinação para estimular a produção de proteínas da matriz extracelular na pele. é revelado um método rápido e barato de produção de formulações heterogêneas de tetrapeptídeos.
BR122018002612A 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo BR122018002612B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81328406P 2006-06-13 2006-06-13
US60/813,284 2006-06-13
BRPI0713153A BRPI0713153B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo
PCT/US2007/013748 WO2007146269A2 (en) 2006-06-13 2007-06-12 Peptide fragments for inducing synthesis of extracellular matrix proteins

Publications (2)

Publication Number Publication Date
BR122018002612B1 BR122018002612B1 (pt) 2021-01-19
BR122018002612B8 true BR122018002612B8 (pt) 2021-07-27

Family

ID=38664422

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0713153A BRPI0713153B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo
BR122018002612A BR122018002612B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0713153A BRPI0713153B8 (pt) 2006-06-13 2007-06-12 tetrapeptídeo capaz de induzir a produção das proteínas da matriz extracelular e composição o compreendendo

Country Status (19)

Country Link
US (5) US8110658B2 (pt)
EP (5) EP2409988B1 (pt)
JP (2) JP5535620B2 (pt)
CN (2) CN101472944B (pt)
AT (1) ATE533785T1 (pt)
AU (1) AU2007258387B2 (pt)
BR (2) BRPI0713153B8 (pt)
CA (4) CA2947353A1 (pt)
CY (1) CY1112241T1 (pt)
DK (3) DK2027152T3 (pt)
ES (4) ES2545219T3 (pt)
HK (5) HK1217346A1 (pt)
HU (2) HUE027273T2 (pt)
MX (2) MX361694B (pt)
PL (4) PL2027152T3 (pt)
PT (2) PT2402369E (pt)
RU (2) RU2441877C2 (pt)
SI (2) SI2409988T1 (pt)
WO (1) WO2007146269A2 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2409988T1 (sl) * 2006-06-13 2015-10-30 Helix Biomedix Inc. Peptidni fragmenti za sprožitev sinteze proteinov zunajcelične matrice
EP2065029B1 (en) * 2007-11-30 2013-04-17 Evonik Goldschmidt GmbH Personal care and cosmetic composition containing tetrapeptides with the motifs GX1X2G, PX1X2P, or PX1X2K
WO2009111471A2 (en) * 2008-03-03 2009-09-11 Henry Ford Health System Collagen-derived peptide as biomarker, therapeutic agent and target
CA2753224C (en) * 2008-12-30 2018-04-17 Gkl-Biotec Ag Peptide combination
US8716438B2 (en) * 2009-10-09 2014-05-06 University of Pittsburgh—of the Commonwealth System of Higher Education Matricryptic ECM peptides for tissue reconstruction
WO2014004719A2 (en) 2012-06-26 2014-01-03 Worcester Polytechnic Institute Matrix scaffold with antimicrobial activity
HUE033976T2 (en) * 2013-02-14 2018-02-28 Helix Biomedix Inc Short, biologically active peptides for wound healing
MX360649B (es) * 2013-03-13 2018-11-12 Anteis Sa Péptidos para el rejuvenecimiento de la piel y métodos de uso de los mismos.
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
RU2687151C2 (ru) * 2013-06-14 2019-05-07 Хеликс Биомедикс Инк. Тетрапептиды, полученные из с-х-с-хемокинов человека, подходящие для лечения различных состояний кожи
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
CA2994279A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
KR101916522B1 (ko) 2015-09-25 2018-11-08 경상대학교산학협력단 굴 가수분해물의 제조방법 및 이로부터 분리된 펩타이드
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
WO2018053201A1 (en) * 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
KR20190064600A (ko) 2016-09-23 2019-06-10 듀크 유니버시티 Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
JP6489486B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 ペンタペプチド／ヘキサペプチドにより変形性関節症を治療するための新規用途
JP6489487B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 テトラペプチド−３ ｇｅｋｇまたはペンタペプチド−３ ｇｅｋｇｆにより変形性関節症を治療するための新規用途
US11554097B2 (en) 2017-05-15 2023-01-17 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
WO2020028806A1 (en) 2018-08-02 2020-02-06 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
EP4000596A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000595A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000598A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000597A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4140473A1 (en) * 2021-08-27 2023-03-01 The Boots Company plc Cosmetic compositions
CN114437238B (zh) * 2022-01-26 2024-03-26 浙江工业大学 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法
CN116375847A (zh) * 2022-10-26 2023-07-04 江苏创健医疗科技股份有限公司 酵母重组xvii型人源化胶原蛋白及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU466760B2 (en) * 1972-03-14 1975-11-06 Takeda Chemical Industries Ltd. Process for producing peptide
US5064430A (en) * 1985-10-31 1991-11-12 Uab Research Foundation Polynonapeptide bioelastomers having an increased elastic modulus
JP2573006B2 (ja) * 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
JP2820750B2 (ja) 1988-04-21 1998-11-05 ユーエービー リサーチ ファウンデイション 創傷治療部位における癒着の発生からの保護に適するバイオエラストマー材料
EP1004595B1 (en) 1989-04-10 2003-06-18 Helix BioMedix, Inc. Lytic and proliferative peptides and their use as pharmaceutic and phytopharmaceutic agents
US5679770A (en) * 1991-11-08 1997-10-21 Mochida Pharmaceutical Co., Ltd. Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
JP3100005B2 (ja) * 1992-07-28 2000-10-16 雪印乳業株式会社 ヒト免疫不全ウィルス感染・増殖抑制剤
US6132976A (en) * 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
IL104954A (en) * 1993-03-04 2006-08-01 Yissum Res Dev Co Use of osteogenic oligopeptides in the preparation of pharmaceutical compositions for the treatment of bone diseases and some such novel oligopeptides, pharmaceutical compositions containing them and their preparation
US5561107A (en) 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
JPH07227281A (ja) * 1994-02-15 1995-08-29 Agency Of Ind Science & Technol ペプチダーゼ及びその製造法
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
US6159940A (en) * 1996-02-28 2000-12-12 Immunotech Developments Inc. Method for modulating hemopoiesis
DE19651099A1 (de) * 1996-12-09 1998-06-10 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
EP1074620A1 (en) * 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
EP0858808B1 (en) * 1997-01-17 2003-04-02 Johnson & Johnson Medical Ltd. Peptides for use in wound treatment
US6639050B1 (en) * 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
GB2341182A (en) * 1998-09-01 2000-03-08 Yamanouchi Uk Ltd Protein comprising amino acid sequences having SH3 domain binding activity and nuclear localisation activity
US6747135B1 (en) * 1998-10-16 2004-06-08 The Board Of Trustees For The Leland Stanford Junior University Fluorescent dye binding peptides
US6492326B1 (en) * 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
CA2276542C (en) * 1999-06-28 2013-07-30 Vladislav I. Deigin Novel peptide, a method for its preparation and a pharmaceutical composition containing the peptide
CN1280983A (zh) * 1999-07-16 2001-01-24 王革 白细胞介素－11的衍生物及其制备方法
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
AU2001255448A1 (en) * 2000-04-17 2001-10-30 Stephen B. Liggett Alpha-2 adrenergic receptor polymorphisms
US20030166510A1 (en) * 2000-10-11 2003-09-04 Pickart Loren R. Methods and compositions for increasing skin remodeling
GB0029777D0 (en) * 2000-12-06 2001-01-17 Regen Therapeutics Plc Peptides
ES2389285T3 (es) 2001-03-28 2012-10-24 Helix Biomedix, Inc. Péptidos bioactivos cortos y procedimientos para su uso
US7186693B2 (en) * 2001-08-16 2007-03-06 Kimberly - Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing
US7041506B2 (en) * 2001-11-19 2006-05-09 Becton Dickinson And Company Peptides promoting cell adherence, growth and secretion
AU2002341904A1 (en) * 2001-11-28 2003-06-10 Becton, Dickinson And Company Peptides with growth inhibitory action
AU2003225540A1 (en) * 2002-01-31 2003-09-02 Irm, Llc Hepsin substrates and prodrugs
AU2003221582A1 (en) * 2002-05-03 2003-11-17 Millenium Biologix Inc. Connective tissue stimulating peptides
ATE464553T1 (de) * 2002-09-09 2010-04-15 Univ Cincinnati Verfahren zur herzerkrankungsbewertung in einer einzelperson
US7541440B2 (en) * 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
TWI256893B (en) * 2003-03-25 2006-06-21 Fancl Corp Composition for promoting production of type I collagen and/or elastin
DE10339180A1 (de) * 2003-08-21 2005-03-24 Deutsche Gelatine-Fabriken Stoess Ag Kollagenhydrolysat
US7638318B2 (en) 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
WO2005048968A1 (en) 2003-11-17 2005-06-02 Sederma Compositions containing mixtures of tetrapeptides and tripeptides
JP2005245285A (ja) * 2004-03-03 2005-09-15 National Institute Of Advanced Industrial & Technology コラーゲン分解物の製造方法
DE102004050563A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Kosmetische und der dermatologische Zusammensetzungen mit Wirkstoffen für einen verbesserten Hautkomfort
DE102005000868A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Zusammensetzungen mit Inhibitoren der Prostaglandin- und/oder Leukotrien-Synthese in Kombination mit Stimulatoren der Freisetzung kutaner Neuromediatoren
DE102004055541A1 (de) * 2004-11-17 2006-05-18 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut
DE202004012807U1 (de) * 2004-08-13 2004-10-21 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen mit DNA-Reparaturenzymen und Oligopeptiden
US20060046271A1 (en) * 2004-09-02 2006-03-02 Vanderbilt University Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides
CA2583113C (en) * 2004-10-05 2015-11-10 Diversa Corporation Compositions comprising an antigen and a promiscuous t-cell epitope
WO2006042661A2 (en) * 2004-10-18 2006-04-27 Cognis France S.A.S Oligopeptides and their use in cosmetics
WO2006048339A2 (en) * 2004-11-04 2006-05-11 L'oréal Cosmetic composition comrising an active agent and a urea compound
US20070224150A1 (en) * 2005-03-24 2007-09-27 Yongji Chung Growth factor for hair and skin treatment
FR2884418B1 (fr) * 2005-04-15 2008-11-21 Soc Extraction Principes Actif Utilisation d'un peptide comme principe actif amincissant
WO2007004869A2 (en) * 2005-07-05 2007-01-11 Biotempt B.V. Treatment of tumors
DE102005063062A1 (de) * 2005-12-29 2007-07-05 Henkel Kgaa Synergistische Proteinhydrolysat-Kombinationen zur Behandlung reifer Haut
US7807625B2 (en) * 2006-01-18 2010-10-05 Grant Industries, Inc Anti-wrinkle composition
SI2409988T1 (sl) * 2006-06-13 2015-10-30 Helix Biomedix Inc. Peptidni fragmenti za sprožitev sinteze proteinov zunajcelične matrice

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CA2947349A1 (en) 2007-12-21
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JP5535620B2 (ja) 2014-07-02
SI2027152T1 (sl) 2012-03-30
US20170157196A1 (en) 2017-06-08
ES2680022T3 (es) 2018-09-03
JP2014129369A (ja) 2014-07-10
MX2008016011A (es) 2009-02-13
US8962798B2 (en) 2015-02-24
HK1128700A1 (en) 2009-11-06
BRPI0713153B8 (pt) 2021-05-25
US20140066380A1 (en) 2014-03-06
PT2409988E (pt) 2015-10-12
HK1210791A1 (en) 2016-05-06
HK1161599A1 (en) 2012-07-27
US20150094270A1 (en) 2015-04-02
CA2655116C (en) 2016-12-13
CN104017071B (zh) 2017-08-15
CY1112241T1 (el) 2015-12-09
EP2940042A2 (en) 2015-11-04
BRPI0713153A2 (pt) 2012-03-27
EP2402369A2 (en) 2012-01-04
CN101472944A (zh) 2009-07-01
US8110658B2 (en) 2012-02-07
HUE027273T2 (en) 2016-10-28
BR122018002612B1 (pt) 2021-01-19
CA2655116A1 (en) 2007-12-21
EP2402369B1 (en) 2015-11-25
ES2375413T3 (es) 2012-02-29
EP2940042A3 (en) 2016-02-17
DK2409988T3 (en) 2015-09-14
RU2441877C2 (ru) 2012-02-10
ES2557402T3 (es) 2016-01-25
DK2402369T3 (en) 2016-02-01
DK2027152T3 (da) 2012-02-20
EP3002294A3 (en) 2016-06-22
EP3002294A2 (en) 2016-04-06
PL3002294T3 (pl) 2018-08-31
ES2545219T3 (es) 2015-09-09
AU2007258387B2 (en) 2012-08-16
EP3002294B8 (en) 2018-05-16
AU2007258387A2 (en) 2009-02-19
RU2009100884A (ru) 2010-07-20
SI2409988T1 (sl) 2015-10-30
BRPI0713153B1 (pt) 2019-05-14
HK1217346A1 (zh) 2017-01-06
EP2402369A3 (en) 2012-05-16
WO2007146269A2 (en) 2007-12-21
PL2409988T3 (pl) 2015-12-31
WO2007146269A3 (en) 2008-08-14
EP2409988A2 (en) 2012-01-25
MX361694B (es) 2018-12-10
PL2027152T3 (pl) 2012-04-30
CA2835369A1 (en) 2007-12-21
CN101472944B (zh) 2014-05-28
US10376557B2 (en) 2019-08-13
RU2011141572A (ru) 2013-04-20
US20070299015A1 (en) 2007-12-27
JP2009539987A (ja) 2009-11-19
EP2409988B1 (en) 2015-07-22
EP2409988A3 (en) 2012-05-09
JP5844834B2 (ja) 2016-01-20
RU2501807C2 (ru) 2013-12-20
PT2402369E (pt) 2016-02-19
HUE026698T2 (en) 2016-07-28
CA2947353A1 (en) 2007-12-21
CA2835369C (en) 2017-01-31
EP2027152B1 (en) 2011-11-16
ATE533785T1 (de) 2011-12-15
US9447143B2 (en) 2016-09-20
CN104017071A (zh) 2014-09-03
HK1161600A1 (zh) 2012-07-27
EP3002294B1 (en) 2018-03-28
US8658764B2 (en) 2014-02-25
AU2007258387A1 (en) 2007-12-21
US20120093740A1 (en) 2012-04-19
EP2027152A2 (en) 2009-02-25

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