ES2680022T3 - Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular - Google Patents

Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular Download PDF

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Publication number
ES2680022T3
ES2680022T3 ES15188894.8T ES15188894T ES2680022T3 ES 2680022 T3 ES2680022 T3 ES 2680022T3 ES 15188894 T ES15188894 T ES 15188894T ES 2680022 T3 ES2680022 T3 ES 2680022T3
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Spain
Prior art keywords
seq
collagen
tetrapeptide
composition
peptides
Prior art date
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Application number
ES15188894.8T
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English (en)
Spanish (es)
Inventor
Scott Harris
Timothy Falla
Lijuan Zhang
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Helix Biomedix Inc
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Helix Biomedix Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
ES15188894.8T 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular Active ES2680022T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81328406P 2006-06-13 2006-06-13
US813284P 2006-06-13

Publications (1)

Publication Number Publication Date
ES2680022T3 true ES2680022T3 (es) 2018-09-03

Family

ID=38664422

Family Applications (4)

Application Number Title Priority Date Filing Date
ES15188894.8T Active ES2680022T3 (es) 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular
ES11175264.8T Active ES2557402T3 (es) 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular
ES07796001T Active ES2375413T3 (es) 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular.
ES11175263.0T Active ES2545219T3 (es) 2006-06-13 2007-06-12 Fragmentos de péptido para inducir la síntesis de las proteínas de la matriz extracelular

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES11175264.8T Active ES2557402T3 (es) 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular
ES07796001T Active ES2375413T3 (es) 2006-06-13 2007-06-12 Fragmentos peptídicos para inducir la síntesis de proteínas de la matriz extracelular.
ES11175263.0T Active ES2545219T3 (es) 2006-06-13 2007-06-12 Fragmentos de péptido para inducir la síntesis de las proteínas de la matriz extracelular

Country Status (19)

Country Link
US (5) US8110658B2 (enExample)
EP (5) EP3002294B8 (enExample)
JP (2) JP5535620B2 (enExample)
CN (2) CN101472944B (enExample)
AT (1) ATE533785T1 (enExample)
AU (1) AU2007258387B2 (enExample)
BR (2) BR122018002612B8 (enExample)
CA (4) CA2947349A1 (enExample)
CY (1) CY1112241T1 (enExample)
DK (3) DK2409988T3 (enExample)
ES (4) ES2680022T3 (enExample)
HK (1) HK1210791A1 (enExample)
HU (2) HUE027273T2 (enExample)
MX (2) MX2008016011A (enExample)
PL (4) PL2402369T3 (enExample)
PT (2) PT2402369E (enExample)
RU (2) RU2501807C2 (enExample)
SI (2) SI2027152T1 (enExample)
WO (1) WO2007146269A2 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3002294B8 (en) * 2006-06-13 2018-05-16 Helix Biomedix Inc. Peptide fragments for inducing synthesis of extracellular matrix proteins
ES2421262T3 (es) * 2007-11-30 2013-08-30 Evonik Goldschmidt Gmbh Composición para el cuidado personal y cosmética que contiene tetrapéptidos con las unidades CX1X2G, PX1X2P o PX1X2K
WO2009111471A2 (en) * 2008-03-03 2009-09-11 Henry Ford Health System Collagen-derived peptide as biomarker, therapeutic agent and target
EP2235038B1 (de) * 2008-12-30 2019-06-05 GKL-Biotec AG Tetrapeptidkombination
US8716438B2 (en) * 2009-10-09 2014-05-06 University of Pittsburgh—of the Commonwealth System of Higher Education Matricryptic ECM peptides for tissue reconstruction
WO2014004719A2 (en) 2012-06-26 2014-01-03 Worcester Polytechnic Institute Matrix scaffold with antimicrobial activity
ES2633437T3 (es) * 2013-02-14 2017-09-21 Helix Biomedix, Inc. Péptidos bioactivos cortos para promover la cicatrización de heridas
CN105189531B (zh) 2013-03-13 2020-02-21 安特易斯有限公司 用于皮肤复新的肽及其使用方法
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
ES2631804T3 (es) * 2013-06-14 2017-09-05 Helix Biomedix Inc. Tetrapéptidos derivados de quimiocinas humanas C-X-C útiles para el tratamiento de diversas afecciones de la piel
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
KR20180033586A (ko) 2015-08-04 2018-04-03 듀크 유니버시티 전달을 위한 유전적으로 인코딩된 내재적으로 무질서화된 스텔스 중합체 및 이의 이용 방법
KR101916522B1 (ko) 2015-09-25 2018-11-08 경상대학교산학협력단 굴 가수분해물의 제조방법 및 이로부터 분리된 펩타이드
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
US11135301B2 (en) 2016-09-14 2021-10-05 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
EP3515928A4 (en) 2016-09-23 2020-04-01 Duke University Unstructured non-repetitive polypeptides having lcst behavior
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
JP6489486B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 ペンタペプチド/ヘキサペプチドにより変形性関節症を治療するための新規用途
JP6489487B2 (ja) * 2017-01-20 2019-03-27 富比積生物科技股▲分▼有限公司 テトラペプチド−3 gekgまたはペンタペプチド−3 gekgfにより変形性関節症を治療するための新規用途
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US11680083B2 (en) 2017-06-30 2023-06-20 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
US12296018B2 (en) 2018-01-26 2025-05-13 Duke University Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
US12257308B2 (en) 2018-04-30 2025-03-25 Duke University Stimuli-responsive PEG-like polymer-based drug delivery platform
WO2020028806A1 (en) 2018-08-02 2020-02-06 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
EP4000595A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000598A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000596A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4000597A1 (en) * 2020-11-17 2022-05-25 The Boots Company plc Tetrapeptide and compositions comprising tetrapeptides
EP4140473A1 (en) * 2021-08-27 2023-03-01 The Boots Company plc Cosmetic compositions
CN115990240A (zh) * 2021-10-20 2023-04-21 富比积生物科技股份有限公司 寡肽在治疗牙龈发炎、牙龈萎缩及修复口腔黏膜中的用途
CN114437238B (zh) * 2022-01-26 2024-03-26 浙江工业大学 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法
CN115894615A (zh) * 2022-10-19 2023-04-04 上海高科生物工程有限公司 一种抗皮肤衰老的五肽衍生肽段ys及其应用
CN116375847B (zh) * 2022-10-26 2025-06-13 江苏创健医疗科技股份有限公司 酵母重组xvii型人源化胶原蛋白及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU466760B2 (en) * 1972-03-14 1975-11-06 Takeda Chemical Industries Ltd. Process for producing peptide
US5064430A (en) * 1985-10-31 1991-11-12 Uab Research Foundation Polynonapeptide bioelastomers having an increased elastic modulus
JP2573006B2 (ja) * 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
WO1989010099A1 (en) * 1988-04-21 1989-11-02 Uab Research Foundation Bioelastomeric materials suitable for the protection of wound repair sites from the occurrence of adhesions
DE69033436T2 (de) 1989-04-10 2000-06-21 Helix Biomedix, Inc. Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs
US5679770A (en) * 1991-11-08 1997-10-21 Mochida Pharmaceutical Co., Ltd. Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
JP3100005B2 (ja) * 1992-07-28 2000-10-16 雪印乳業株式会社 ヒト免疫不全ウィルス感染・増殖抑制剤
US6132976A (en) * 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
IL104954A (en) * 1993-03-04 2006-08-01 Yissum Res Dev Co Use of osteogenic oligopeptides in the preparation of pharmaceutical compositions for the treatment of bone diseases and some such novel oligopeptides, pharmaceutical compositions containing them and their preparation
US5561107A (en) 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
JPH07227281A (ja) * 1994-02-15 1995-08-29 Agency Of Ind Science & Technol ペプチダーゼ及びその製造法
US5763576A (en) * 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
US6159940A (en) * 1996-02-28 2000-12-12 Immunotech Developments Inc. Method for modulating hemopoiesis
DE19651099A1 (de) * 1996-12-09 1998-06-10 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
EP1074620A1 (en) * 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
EP0858808B1 (en) * 1997-01-17 2003-04-02 Johnson & Johnson Medical Ltd. Peptides for use in wound treatment
US6639050B1 (en) * 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
GB2341182A (en) * 1998-09-01 2000-03-08 Yamanouchi Uk Ltd Protein comprising amino acid sequences having SH3 domain binding activity and nuclear localisation activity
US6747135B1 (en) * 1998-10-16 2004-06-08 The Board Of Trustees For The Leland Stanford Junior University Fluorescent dye binding peptides
US6492326B1 (en) * 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
CA2276542C (en) * 1999-06-28 2013-07-30 Vladislav I. Deigin Novel peptide, a method for its preparation and a pharmaceutical composition containing the peptide
CN1280983A (zh) * 1999-07-16 2001-01-24 王革 白细胞介素-11的衍生物及其制备方法
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
AU2001255448A1 (en) * 2000-04-17 2001-10-30 Stephen B. Liggett Alpha-2 adrenergic receptor polymorphisms
US20030166510A1 (en) * 2000-10-11 2003-09-04 Pickart Loren R. Methods and compositions for increasing skin remodeling
GB0029777D0 (en) * 2000-12-06 2001-01-17 Regen Therapeutics Plc Peptides
ES2389285T3 (es) 2001-03-28 2012-10-24 Helix Biomedix, Inc. Péptidos bioactivos cortos y procedimientos para su uso
US7186693B2 (en) * 2001-08-16 2007-03-06 Kimberly - Clark Worldwide, Inc. Metalloproteinase inhibitors for wound healing
US7041506B2 (en) * 2001-11-19 2006-05-09 Becton Dickinson And Company Peptides promoting cell adherence, growth and secretion
CA2468187A1 (en) * 2001-11-28 2003-06-05 Becton, Dickinson And Company Peptides with growth inhibitory action
US20040009911A1 (en) * 2002-01-31 2004-01-15 Irm, Llc Hepsin substrates and prodrugs
EP1504033A2 (en) * 2002-05-03 2005-02-09 Millenium Biologix Inc. Connective tissue stimulating peptides
EP1576352B1 (en) * 2002-09-09 2010-04-14 University Of Cincinnati Methods of cardiovascular disease assessment in an individual
US7541440B2 (en) * 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
TWI256893B (en) * 2003-03-25 2006-06-21 Fancl Corp Composition for promoting production of type I collagen and/or elastin
DE10339180A1 (de) * 2003-08-21 2005-03-24 Deutsche Gelatine-Fabriken Stoess Ag Kollagenhydrolysat
US7638318B2 (en) 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
JP4256389B2 (ja) 2003-11-17 2009-04-22 セダーマ テトラペプチドとトリペプチドの混合物を含む組成物
JP2005245285A (ja) * 2004-03-03 2005-09-15 National Institute Of Advanced Industrial & Technology コラーゲン分解物の製造方法
DE102005000868A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Zusammensetzungen mit Inhibitoren der Prostaglandin- und/oder Leukotrien-Synthese in Kombination mit Stimulatoren der Freisetzung kutaner Neuromediatoren
DE202004012807U1 (de) * 2004-08-13 2004-10-21 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen mit DNA-Reparaturenzymen und Oligopeptiden
DE102004050563A1 (de) * 2004-10-15 2006-04-20 Henkel Kgaa Kosmetische und der dermatologische Zusammensetzungen mit Wirkstoffen für einen verbesserten Hautkomfort
DE102004055541A1 (de) * 2004-11-17 2006-05-18 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen zur Behandlung reifer Haut
US20060046271A1 (en) * 2004-09-02 2006-03-02 Vanderbilt University Assessment of cancer susceptibility to molecular targeted therapy by use of recombinant peptides
GB2434367B (en) * 2004-10-05 2010-05-12 Diversa Corp Improved vaccines
WO2006042661A2 (en) * 2004-10-18 2006-04-27 Cognis France S.A.S Oligopeptides and their use in cosmetics
WO2006048339A2 (en) * 2004-11-04 2006-05-11 L'oréal Cosmetic composition comrising an active agent and a urea compound
US20070224150A1 (en) * 2005-03-24 2007-09-27 Yongji Chung Growth factor for hair and skin treatment
FR2884418B1 (fr) * 2005-04-15 2008-11-21 Soc Extraction Principes Actif Utilisation d'un peptide comme principe actif amincissant
WO2007004869A2 (en) * 2005-07-05 2007-01-11 Biotempt B.V. Treatment of tumors
DE102005063062A1 (de) * 2005-12-29 2007-07-05 Henkel Kgaa Synergistische Proteinhydrolysat-Kombinationen zur Behandlung reifer Haut
US7807625B2 (en) * 2006-01-18 2010-10-05 Grant Industries, Inc Anti-wrinkle composition
EP3002294B8 (en) * 2006-06-13 2018-05-16 Helix Biomedix Inc. Peptide fragments for inducing synthesis of extracellular matrix proteins

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