ATE189231T1 - Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs - Google Patents
Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebsInfo
- Publication number
- ATE189231T1 ATE189231T1 AT90906453T AT90906453T ATE189231T1 AT E189231 T1 ATE189231 T1 AT E189231T1 AT 90906453 T AT90906453 T AT 90906453T AT 90906453 T AT90906453 T AT 90906453T AT E189231 T1 ATE189231 T1 AT E189231T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- amino acids
- peptide
- cancer
- infections
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002101 lytic effect Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 8
- 229940024606 amino acid Drugs 0.000 abstract 7
- 239000004475 Arginine Substances 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 108010062796 arginyllysine Proteins 0.000 abstract 1
- 229940009098 aspartate Drugs 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33618189A | 1989-04-10 | 1989-04-10 | |
| PCT/US1990/001945 WO1990012866A1 (en) | 1989-04-10 | 1990-04-10 | Lytic peptides, use for growth, infection and cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189231T1 true ATE189231T1 (de) | 2000-02-15 |
Family
ID=23314920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90906453T ATE189231T1 (de) | 1989-04-10 | 1990-04-10 | Lytische peptide, verwendung als wachstumsfördernde mittel und für infektionen und krebs |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1004595B1 (de) |
| AT (1) | ATE189231T1 (de) |
| AU (1) | AU5433190A (de) |
| CA (1) | CA2032527C (de) |
| DE (2) | DE69034085T2 (de) |
| WO (1) | WO1990012866A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0667871A1 (de) * | 1991-09-13 | 1995-08-23 | Magainin Pharmaceuticals Inc. | Biologisch aktive amphiphile peptidzusammensetzungen und ihre verwendungen |
| US5850025A (en) * | 1991-09-19 | 1998-12-15 | Sibia Neurosciences, Inc. | Protection of plants against plant pathogens |
| US5422108A (en) * | 1991-09-19 | 1995-06-06 | Smart Plants International Inc. | Protection of plants against plant pathogens |
| US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5919761A (en) * | 1992-08-14 | 1999-07-06 | The Board Of Regents Of The University Of Michigan | Peptides for heparin and low molecular weight heparin anticoagulation reversal |
| US5614494A (en) * | 1993-11-12 | 1997-03-25 | University Of Michigan, The Board Of Regents Acting For And On Behalf Of | Peptides for heparin and low molecular weight heparin anticoagulation reversal |
| US5534619A (en) * | 1993-11-12 | 1996-07-09 | The Board Of Regents Acting On Behalf Of University Of Michigan | Peptides for heparin and low molecular weight heparin anticoagulation reversal |
| US5955573A (en) * | 1993-06-04 | 1999-09-21 | Demegen, Inc. | Ubiquitin-lytic peptide fusion gene constructs, protein products deriving therefrom, and methods of making and using same |
| US5773413A (en) * | 1993-06-04 | 1998-06-30 | Demeter Biotechnologies, Ltd. | Method of combating mammalian neoplasias, and lytic peptides therefor |
| US5968904A (en) * | 1993-06-04 | 1999-10-19 | Demegen, Inc. | Modified arginine containing lytic peptides and method of making the same by glyoxylation |
| US5561107A (en) * | 1993-06-04 | 1996-10-01 | Demeter Biotechnologies, Ltd. | Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides |
| WO1995001095A1 (en) * | 1993-06-30 | 1995-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Transformed eukaryotic cells, and transposon-based transformation vectors |
| US6156568A (en) * | 1993-06-30 | 2000-12-05 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Transformed eukaryotic cells |
| AU7217194A (en) * | 1993-06-30 | 1995-01-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The | Transformed mammalian cells capable of expressing cecropin b |
| US5856178A (en) * | 1993-08-30 | 1999-01-05 | Utah State University | DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same |
| AU1086595A (en) * | 1993-11-08 | 1995-05-29 | Demeter Biotechnologies, Ltd. | Methylated lysine-rich lytic peptides and method of making same by reductive alkylation |
| IL113244A0 (en) * | 1994-04-08 | 1995-07-31 | Demeter Biotech Ltd | Method of combating mammalian neoplasia and lytic peptides therefor |
| US5789542A (en) * | 1994-04-22 | 1998-08-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Amphipathic peptides |
| IL114697A0 (en) | 1994-07-22 | 1995-11-27 | Demeter Biotech Ltd | Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use |
| US6057291A (en) | 1995-06-02 | 2000-05-02 | University Of British Columbia | Antimicrobial cationic peptides |
| US5877274A (en) * | 1995-06-02 | 1999-03-02 | University Of British Columbia | Antimicrobial cationic peptides |
| US5998698A (en) * | 1995-06-07 | 1999-12-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Transgenic fish capable of expressing exogenous lytic peptides |
| AU4602897A (en) | 1996-10-04 | 1998-04-24 | Demegen, Inc. | Method for treatment of immunodeficiency virus infection |
| US6566334B1 (en) | 1997-02-06 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
| US6635740B1 (en) | 1997-03-27 | 2003-10-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Ligand/lytic peptide compositions and methods of use |
| AU6587998A (en) * | 1997-03-27 | 1998-10-20 | Demeter Biotechnologies, Ltd. | Ligand/lytic peptide compositions and methods of use |
| US6680058B1 (en) | 1997-09-03 | 2004-01-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for contraception in or sterilization of mammals |
| DE19749973C1 (de) * | 1997-11-05 | 1998-10-22 | Klaus Dr Duering | Lysozym-analoge Proteine und Peptide mit antimikrobieller Wirkung, ihre Herstellung und ihre Verwendung |
| WO2000053775A2 (en) * | 1999-03-10 | 2000-09-14 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Prevention and treatment of viral infections |
| US6875744B2 (en) | 2001-03-28 | 2005-04-05 | Helix Biomedix, Inc. | Short bioactive peptides |
| WO2002079408A2 (en) * | 2001-03-28 | 2002-10-10 | Helix Biomedix, Inc. | Short bioactive peptides and methods for their use |
| DE60329382D1 (de) | 2002-04-22 | 2009-11-05 | Dow Global Technologies Inc | Kostengünstige herstellung von peptiden |
| US7122621B2 (en) * | 2003-06-17 | 2006-10-17 | Academia Sinica | Anti-cellular proliferative disorder polypeptide |
| JP5335241B2 (ja) | 2005-02-09 | 2013-11-06 | ヘリックス バイオメディックス インコーポレイテッド | 抗微生物ヘキサペプチド |
| CA2835369C (en) | 2006-06-13 | 2017-01-31 | Helix Biomedix Inc. | Peptide fragments for inducing synthesis of extracellular matrix proteins |
| WO2008085494A1 (en) * | 2007-01-05 | 2008-07-17 | Helix Biomedix Inc. | Short bio-active peptides for cellular and immunological modulation |
| EP2205623B1 (de) | 2007-10-29 | 2016-03-16 | Helix Biomedix Inc. | Protektive hautpflege-tetrapeptide |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| US8461118B2 (en) * | 2011-07-07 | 2013-06-11 | Tuskegee University | Lytic peptides having anti-proliferative activity against prostate cancer cells |
| CA2964361A1 (en) | 2014-10-14 | 2016-04-21 | The Usa, As Represented By The Secretary, Dept. Of Health & Human Services | Peptide-based methods for treating pancreatic cancer |
| JP6840086B2 (ja) | 2015-03-20 | 2021-03-10 | ユニベルシテ・パリ・デカルトＵｎｉｖｅｒｓｉｔｅ Ｐａｒｉｓ Ｄｅｓｃａｒｔｅｓ | 薬物として、特に皮膚炎症性疾患において使用するためのフィブリノゲン由来の単離されたペプチドおよびそれらのフラグメント |
| WO2016154328A2 (en) * | 2015-03-23 | 2016-09-29 | Riptide Bioscience, Inc. | Antimicrobial peptides and methods of use thereof |
| US10413584B1 (en) | 2018-08-29 | 2019-09-17 | Riptide Bioscience, Inc. | Peptides having immunomodulatory properties |
| US10548944B1 (en) | 2018-10-19 | 2020-02-04 | Riptide Bioscience, Inc. | Antimicrobial peptides and methods of using the same |
| CA3134420A1 (en) | 2019-04-12 | 2020-10-15 | Riptide Bioscience, Inc. | Methods for modulating macrophage activity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4355104A (en) * | 1980-06-17 | 1982-10-19 | Kabigen Ab | Bacteriolytic proteins |
| US4643988A (en) * | 1984-05-15 | 1987-02-17 | Research Corporation | Amphipathic peptides |
| ATE127838T1 (de) * | 1987-07-06 | 1995-09-15 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| EP0675960A1 (de) * | 1987-11-02 | 1995-10-11 | Louisiana State University and Agricultural and Mechanical College | Genetisch erhöhte, gegen krankheit resistente pflanzen |
-
1990
- 1990-04-10 EP EP99122942A patent/EP1004595B1/de not_active Expired - Lifetime
- 1990-04-10 WO PCT/US1990/001945 patent/WO1990012866A1/en not_active Ceased
- 1990-04-10 AT AT90906453T patent/ATE189231T1/de not_active IP Right Cessation
- 1990-04-10 DE DE69034085T patent/DE69034085T2/de not_active Expired - Lifetime
- 1990-04-10 EP EP90906453A patent/EP0470974B1/de not_active Expired - Lifetime
- 1990-04-10 AU AU54331/90A patent/AU5433190A/en not_active Abandoned
- 1990-04-10 DE DE69033436T patent/DE69033436T2/de not_active Expired - Lifetime
- 1990-04-10 CA CA002032527A patent/CA2032527C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990012866A1 (en) | 1990-11-01 |
| AU5433190A (en) | 1990-11-16 |
| EP1004595A3 (de) | 2000-11-02 |
| CA2032527A1 (en) | 1990-10-11 |
| EP0470974A1 (de) | 1992-02-19 |
| CA2032527C (en) | 2002-07-02 |
| EP0470974A4 (en) | 1992-09-16 |
| EP1004595A2 (de) | 2000-05-31 |
| DE69034085T2 (de) | 2004-05-27 |
| DE69033436T2 (de) | 2000-06-21 |
| EP0470974B1 (de) | 2000-01-26 |
| EP1004595B1 (de) | 2003-06-18 |
| DE69033436D1 (de) | 2000-03-02 |
| DE69034085D1 (de) | 2003-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |