WO2010056040A2 - 생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체 - Google Patents

생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체 Download PDF

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Publication number
WO2010056040A2
WO2010056040A2 PCT/KR2009/006620 KR2009006620W WO2010056040A2 WO 2010056040 A2 WO2010056040 A2 WO 2010056040A2 KR 2009006620 W KR2009006620 W KR 2009006620W WO 2010056040 A2 WO2010056040 A2 WO 2010056040A2
Authority
WO
WIPO (PCT)
Prior art keywords
biocompatible polymer
erythropoietin
conjugates
erythropoietin conjugates
bonded
Prior art date
Application number
PCT/KR2009/006620
Other languages
English (en)
French (fr)
Other versions
WO2010056040A3 (ko
Inventor
박명옥
Original Assignee
주식회사 바이오폴리메드
한국유니온제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 바이오폴리메드, 한국유니온제약 주식회사 filed Critical 주식회사 바이오폴리메드
Publication of WO2010056040A2 publication Critical patent/WO2010056040A2/ko
Publication of WO2010056040A3 publication Critical patent/WO2010056040A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 생물학적 활성 물질인 에리스로포이에틴의 C-말단(C-terminal)을 포함한 아미노산의 카르복실기에 비항원 친수성 생체적합성 고분자를 접합한 접합체에 관한 것이다. 상기 에리스로포이에틴과 생체적합성 고분자의 접합체는 에리스로포이에틴의 생리활성의 저하를 최대한 감소시키고 혈중 혈청 반감기를 증가시켜 체내 약물의 효능을 높임으로써, 적혈구 생성 및 조혈에 관련된 질환의 치료에 유용하게 사용될 수 있다.
PCT/KR2009/006620 2008-11-11 2009-11-11 생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체 WO2010056040A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0111568 2008-11-11
KR1020080111568A KR20100052730A (ko) 2008-11-11 2008-11-11 생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체

Publications (2)

Publication Number Publication Date
WO2010056040A2 true WO2010056040A2 (ko) 2010-05-20
WO2010056040A3 WO2010056040A3 (ko) 2010-08-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006620 WO2010056040A2 (ko) 2008-11-11 2009-11-11 생체적합성 고분자와 결합한 신규한 에리스로포이에틴 접합체

Country Status (2)

Country Link
KR (1) KR20100052730A (ko)
WO (1) WO2010056040A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2663285C2 (ru) * 2017-01-31 2018-08-03 Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") Средство, обладающее гемостимулирующей активностью, и способ его получения
KR102268647B1 (ko) * 2017-06-12 2021-06-23 한국코러스 주식회사 안정성이 향상된 에리스로포이에틴 조성물 및 이의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016555A1 (en) * 1991-03-18 1992-10-01 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
US20060134736A1 (en) * 2003-03-28 2006-06-22 Jacobs John W Human growth hormone conjugated with biocompatible polymer
US20070117924A1 (en) * 2003-03-28 2007-05-24 Myung-Ok Park Biologically active material conjugated with biocompatible polymer with 1:1 complex, preparation method thereof and pharmaceutical composition comprising the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016555A1 (en) * 1991-03-18 1992-10-01 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
US20060134736A1 (en) * 2003-03-28 2006-06-22 Jacobs John W Human growth hormone conjugated with biocompatible polymer
US20070117924A1 (en) * 2003-03-28 2007-05-24 Myung-Ok Park Biologically active material conjugated with biocompatible polymer with 1:1 complex, preparation method thereof and pharmaceutical composition comprising the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LONG, D.L. ET AL.: 'Design of Homogeneous, MonoPEGylated Erythropoietin Analogs With Preserved In Vitro Bioactivity' EXPERIMENTAL HEMATOLOGY vol. 34, no. 6, 2006, pages 697 - 704 *

Also Published As

Publication number Publication date
WO2010056040A3 (ko) 2010-08-26
KR20100052730A (ko) 2010-05-20

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