WO2011071280A3 - 세포내 타겟 결합용 바이포달 펩타이드 바인더 - Google Patents

세포내 타겟 결합용 바이포달 펩타이드 바인더 Download PDF

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Publication number
WO2011071280A3
WO2011071280A3 PCT/KR2010/008646 KR2010008646W WO2011071280A3 WO 2011071280 A3 WO2011071280 A3 WO 2011071280A3 KR 2010008646 W KR2010008646 W KR 2010008646W WO 2011071280 A3 WO2011071280 A3 WO 2011071280A3
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WO
WIPO (PCT)
Prior art keywords
peptide binder
bipodal peptide
bonded
target
region
Prior art date
Application number
PCT/KR2010/008646
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English (en)
French (fr)
Other versions
WO2011071280A9 (ko
WO2011071280A2 (ko
Inventor
전상용
김성현
김대진
Original Assignee
광주과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 광주과학기술원 filed Critical 광주과학기술원
Priority to KR1020127015777A priority Critical patent/KR20120125455A/ko
Priority to US13/515,026 priority patent/US20120309934A1/en
Priority to JP2012543021A priority patent/JP5677454B2/ja
Publication of WO2011071280A2 publication Critical patent/WO2011071280A2/ko
Publication of WO2011071280A9 publication Critical patent/WO2011071280A9/ko
Publication of WO2011071280A3 publication Critical patent/WO2011071280A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 (a) 가닥간(interstrand) 비공유결합이 형성된 패러럴(parallel), 안티패러럴(antiparallel) 또는 패러럴(parallel)과 안티패러럴(antiparallel) 아미노산 가닥들을 포함하는 구조 안정화 부위(structure stabilizing region); (b) 상기 구조 안정화 부위의 양 말단에 결합되어 있고 무작위적으로 선택된 각각 n 및 m개의 아미노산을 포함하는 타겟 결합 부위 I(target binding region I) 및 타겟 결합 부위 Ⅱ(target binding region Ⅱ); 및 (c) 상기 구조 안정화 부위 또는 상기 타겟 결합 부위에 결합된 세포막투과 펩타이드(CPP)를 포함하는 세포내 타겟분자에 특이적으로 결합하는 세포내 타겟팅(intracellular targeting) 바이포달 펩타이드 바인더, 그리고 그의 제조방법에 관한 것으로서, 본 발명의 세포 내 타겟분자에 결합하여, 의약으로서의 용도, 인 비보 분자 이미징, 인 비트로 세포 이미징 및 약물전달용 타겟팅을 하는 데 이용될 수 있으며, 에스코트 분자로도 매우 유용하게 이용될 수 있다.
PCT/KR2010/008646 2009-12-11 2010-12-03 세포내 타겟 결합용 바이포달 펩타이드 바인더 WO2011071280A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020127015777A KR20120125455A (ko) 2009-12-11 2010-12-03 세포내 타겟 결합용 바이포달 펩타이드 바인더
US13/515,026 US20120309934A1 (en) 2009-12-11 2010-12-03 Intracelluar targeting bipodal peptide binder
JP2012543021A JP5677454B2 (ja) 2009-12-11 2010-12-03 細胞内ターゲット結合用二座ペプチドバインダー

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0123134 2009-12-11
KR20090123134 2009-12-11

Publications (3)

Publication Number Publication Date
WO2011071280A2 WO2011071280A2 (ko) 2011-06-16
WO2011071280A9 WO2011071280A9 (ko) 2011-08-25
WO2011071280A3 true WO2011071280A3 (ko) 2011-11-10

Family

ID=44146029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/008646 WO2011071280A2 (ko) 2009-12-11 2010-12-03 세포내 타겟 결합용 바이포달 펩타이드 바인더

Country Status (4)

Country Link
US (1) US20120309934A1 (ko)
JP (1) JP5677454B2 (ko)
KR (1) KR20120125455A (ko)
WO (1) WO2011071280A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010047515A2 (ko) 2008-10-20 2010-04-29 광주과학기술원 바이포달 펩타이드 바인더
KR101323846B1 (ko) * 2011-04-08 2013-10-31 광주과학기술원 타겟 친화도가 유지되고 안정성이 개선된 ｄ－앱타이드
WO2013061818A1 (ja) * 2011-10-25 2013-05-02 国立大学法人岡山大学 新規ペプチド複合体、そのハイブリッド複合体およびその用途
KR102092345B1 (ko) 2013-09-30 2020-03-24 삼성전자주식회사 류신 지퍼 변이체 및 이의 용도
KR101531944B1 (ko) * 2013-12-24 2015-06-29 광주과학기술원 Ｖｅｇｆ에 특이적으로 결합하는 ｖｅｇｆ－ｂｐｂ
KR20150118252A (ko) * 2014-04-11 2015-10-22 한국과학기술원 환형의 β-헤어핀 기반 펩타이드 바인더 및 이의 제조방법
KR102272213B1 (ko) 2014-07-08 2021-07-01 삼성전자주식회사 표적화 부위, 절단 부위, 및 세포막 투과 부위를 포함하는 융합 단백질 및 그의 용도
US20190284243A1 (en) 2016-11-11 2019-09-19 University Of Copenhagen Binding peptides
KR101971092B1 (ko) * 2017-06-28 2019-04-23 한국세라믹기술원 아세틸콜린수용체 결합 펩타이드

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ATE296350T1 (de) * 1999-06-14 2005-06-15 Genentech Inc Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage
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US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
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Also Published As

Publication number Publication date
JP5677454B2 (ja) 2015-02-25
US20120309934A1 (en) 2012-12-06
KR20120125455A (ko) 2012-11-15
JP2013513382A (ja) 2013-04-22
WO2011071280A9 (ko) 2011-08-25
WO2011071280A2 (ko) 2011-06-16

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