BRPI0607400A2 - derivados do ácido [isoquinolin-3-(carbonil)amino]-propiÈnico como inibidores dos fatores xi e ix para o tratamento de trombose - Google Patents
derivados do ácido [isoquinolin-3-(carbonil)amino]-propiÈnico como inibidores dos fatores xi e ix para o tratamento de tromboseInfo
- Publication number
- BRPI0607400A2 BRPI0607400A2 BRPI0607400-6A BRPI0607400A BRPI0607400A2 BR PI0607400 A2 BRPI0607400 A2 BR PI0607400A2 BR PI0607400 A BRPI0607400 A BR PI0607400A BR PI0607400 A2 BRPI0607400 A2 BR PI0607400A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoquinolin
- carbonyl
- inhibitors
- factors
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
DERIVADOS DO áCIDO [ISOQUINOLIN-3-(CARBONIL)AMINOI-PROPIÈNICO COMO INIBIDORES DOS FATORES XI E IX PARA O TRATAMENTO DE TROMBOSE. Essa invenção provê compostos de arila e heteroarua de fórmula (X) Os compostos da invenção podem ser úteis como antagonistas, ou antagonistas parciais do fator IX e/ou do fator XI e assim, podem ser usados para inibir a via intrínseca da coagulação sanguínea. A fórmula (X) em que R~ 102~ é selecionado do grupo que consiste em - C(O)OH, - C(O)OCH~ 3~, - C(O)O-t-butila, -C(O)NH-OCH~ 2~-fenila, C(O)NHOH e - C(O) NHSO~ 2~CH~ 3~; e em que R~ 101~, R~ 103~, R~ 104~ e Y são conforme aqui definido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/069,521 US7208601B2 (en) | 2003-08-08 | 2005-03-01 | Aryl and heteroaryl compounds, compositions, and methods of use |
PCT/US2006/006571 WO2006093823A1 (en) | 2005-03-01 | 2006-02-23 | 2- [ isoquinolin-s - carbonyl ) amino] -propionic acid derivatives as inhibitors of factors xi and ix for the treatment of thrombosis |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0607400A2 true BRPI0607400A2 (pt) | 2009-09-01 |
Family
ID=36539849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0607400-6A BRPI0607400A2 (pt) | 2005-03-01 | 2006-02-23 | derivados do ácido [isoquinolin-3-(carbonil)amino]-propiÈnico como inibidores dos fatores xi e ix para o tratamento de trombose |
Country Status (11)
Country | Link |
---|---|
US (2) | US7208601B2 (pt) |
EP (1) | EP1888566A1 (pt) |
JP (1) | JP2008531689A (pt) |
CN (1) | CN101137650A (pt) |
AU (1) | AU2006218815A1 (pt) |
BR (1) | BRPI0607400A2 (pt) |
CA (1) | CA2599808A1 (pt) |
IL (1) | IL185428A0 (pt) |
MX (1) | MX2007010682A (pt) |
WO (1) | WO2006093823A1 (pt) |
ZA (1) | ZA200707508B (pt) |
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-
2005
- 2005-03-01 US US11/069,521 patent/US7208601B2/en not_active Expired - Fee Related
-
2006
- 2006-02-23 AU AU2006218815A patent/AU2006218815A1/en not_active Abandoned
- 2006-02-23 CA CA002599808A patent/CA2599808A1/en not_active Abandoned
- 2006-02-23 BR BRPI0607400-6A patent/BRPI0607400A2/pt not_active IP Right Cessation
- 2006-02-23 ZA ZA200707508A patent/ZA200707508B/xx unknown
- 2006-02-23 MX MX2007010682A patent/MX2007010682A/es not_active Application Discontinuation
- 2006-02-23 CN CNA2006800069585A patent/CN101137650A/zh active Pending
- 2006-02-23 WO PCT/US2006/006571 patent/WO2006093823A1/en active Application Filing
- 2006-02-23 JP JP2007558080A patent/JP2008531689A/ja active Pending
- 2006-02-23 EP EP06736003A patent/EP1888566A1/en not_active Withdrawn
-
2007
- 2007-03-05 US US11/714,031 patent/US20070254916A1/en not_active Abandoned
- 2007-08-21 IL IL185428A patent/IL185428A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007010682A (es) | 2007-11-07 |
US20050171148A1 (en) | 2005-08-04 |
JP2008531689A (ja) | 2008-08-14 |
EP1888566A1 (en) | 2008-02-20 |
ZA200707508B (en) | 2008-12-31 |
WO2006093823A9 (en) | 2006-11-02 |
WO2006093823A1 (en) | 2006-09-08 |
CA2599808A1 (en) | 2006-09-08 |
CN101137650A (zh) | 2008-03-05 |
IL185428A0 (en) | 2008-01-06 |
AU2006218815A1 (en) | 2006-09-08 |
US20070254916A1 (en) | 2007-11-01 |
US7208601B2 (en) | 2007-04-24 |
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