BRPI0519407A2 - preparaÇço de liberaÇço sustentada do tipo matriz contendo droga bÁsica ou seu sal e mÉtodo para a fabricaÇço da mesma - Google Patents
preparaÇço de liberaÇço sustentada do tipo matriz contendo droga bÁsica ou seu sal e mÉtodo para a fabricaÇço da mesmaInfo
- Publication number
- BRPI0519407A2 BRPI0519407A2 BRPI0519407-5A BRPI0519407A BRPI0519407A2 BR PI0519407 A2 BRPI0519407 A2 BR PI0519407A2 BR PI0519407 A BRPI0519407 A BR PI0519407A BR PI0519407 A2 BRPI0519407 A2 BR PI0519407A2
- Authority
- BR
- Brazil
- Prior art keywords
- dissolution
- salt
- basic drug
- drug
- sustained release
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PREPARAÇçO DE LIBERAÇçO SUSTENTADA DO TIPO MATRIZ CONTENDO DROGA BÁSICA OU SEU SAL E MÉTODO PARA A FABRICAÇçO DA MESMA. Preparação de liberação sustentada do tipo matriz e um método de fabricação para a mesma são proporcionados em que a dissolução com dependência de um baixo pH de uma droga básica ou seu sal no estágio inicial de dissolução pode ser assegurada em um teste de dissolução, e em que à medida que o teste de dissolução prossegue, a relação de uma taxa de dissolução da droga básica ou o seu sal em uma solução ácida de teste para uma taxa de dissolução da droga básica ou seu sal em uma solução neutra de teste (taxa de dissolução na solução ácida de teste / taxa de dissolução na solução neutra de teste) diminui com o tempo de dissolução no último estágio de dissolução, quando comparado com o estágio inicial de dissolução. De acordo com a presente invenção, a preparação de liberação sustentada do tipo matriz contém uma droga básica ou seu sal e pelo menos um polímero entérico, em que a solubilidade da droga básica ou seu sal em uma solução de ácido clorídrico a 0,1 N e a solução aquosa neutra, pH 6,0 é maior do que em uma solução aquosa básica, pH 8,0.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004376770 | 2004-12-27 | ||
JP2005110404 | 2005-04-06 | ||
US67548205P | 2005-04-28 | 2005-04-28 | |
JP2005132338 | 2005-04-28 | ||
PCT/JP2005/023853 WO2006070781A1 (ja) | 2004-12-27 | 2005-12-27 | 塩基性薬物又はその塩を含有するマトリックス型徐放性製剤およびその製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0519407A2 true BRPI0519407A2 (pt) | 2009-01-20 |
Family
ID=36614895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0519407-5A BRPI0519407A2 (pt) | 2004-12-27 | 2005-12-27 | preparaÇço de liberaÇço sustentada do tipo matriz contendo droga bÁsica ou seu sal e mÉtodo para a fabricaÇço da mesma |
Country Status (13)
Country | Link |
---|---|
US (2) | US20090208579A1 (pt) |
EP (1) | EP1832298A4 (pt) |
JP (1) | JP4999466B2 (pt) |
KR (1) | KR100904602B1 (pt) |
CN (1) | CN103550190A (pt) |
AU (1) | AU2005320609B9 (pt) |
BR (1) | BRPI0519407A2 (pt) |
CA (1) | CA2592102C (pt) |
IL (1) | IL183871A0 (pt) |
MX (1) | MX2007007835A (pt) |
NO (1) | NO20073461L (pt) |
NZ (1) | NZ555901A (pt) |
WO (1) | WO2006070781A1 (pt) |
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-
2005
- 2005-12-12 US US11/794,212 patent/US20090208579A1/en not_active Abandoned
- 2005-12-27 MX MX2007007835A patent/MX2007007835A/es active IP Right Grant
- 2005-12-27 CN CN201310421659.XA patent/CN103550190A/zh active Pending
- 2005-12-27 EP EP05822550A patent/EP1832298A4/en not_active Withdrawn
- 2005-12-27 AU AU2005320609A patent/AU2005320609B9/en not_active Ceased
- 2005-12-27 BR BRPI0519407-5A patent/BRPI0519407A2/pt not_active Application Discontinuation
- 2005-12-27 CA CA2592102A patent/CA2592102C/en not_active Expired - Fee Related
- 2005-12-27 WO PCT/JP2005/023853 patent/WO2006070781A1/ja active Application Filing
- 2005-12-27 KR KR1020077014510A patent/KR100904602B1/ko active IP Right Grant
- 2005-12-27 NZ NZ555901A patent/NZ555901A/en not_active IP Right Cessation
- 2005-12-27 JP JP2006550780A patent/JP4999466B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-12 IL IL183871A patent/IL183871A0/en unknown
- 2007-07-04 NO NO20073461A patent/NO20073461L/no not_active Application Discontinuation
-
2010
- 2010-10-22 US US12/910,313 patent/US20110045074A1/en not_active Abandoned
Also Published As
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IL183871A0 (en) | 2007-10-31 |
CA2592102C (en) | 2012-01-24 |
US20090208579A1 (en) | 2009-08-20 |
US20110045074A1 (en) | 2011-02-24 |
NO20073461L (no) | 2007-09-27 |
AU2005320609A1 (en) | 2006-07-06 |
CA2592102A1 (en) | 2006-07-06 |
KR20070089207A (ko) | 2007-08-30 |
MX2007007835A (es) | 2007-08-20 |
KR100904602B1 (ko) | 2009-06-25 |
WO2006070781A1 (ja) | 2006-07-06 |
CN103550190A (zh) | 2014-02-05 |
JP4999466B2 (ja) | 2012-08-15 |
NZ555901A (en) | 2010-10-29 |
AU2005320609B9 (en) | 2010-03-18 |
EP1832298A1 (en) | 2007-09-12 |
AU2005320609B2 (en) | 2009-07-02 |
JPWO2006070781A1 (ja) | 2008-06-12 |
EP1832298A4 (en) | 2012-12-12 |
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