NO20073461L - Matrikstypepreparater for vedvarende frigjoring som inneholder basiske medikamenter eller salter derav, samt fremgangsmate for fremstilling derav - Google Patents

Matrikstypepreparater for vedvarende frigjoring som inneholder basiske medikamenter eller salter derav, samt fremgangsmate for fremstilling derav

Info

Publication number
NO20073461L
NO20073461L NO20073461A NO20073461A NO20073461L NO 20073461 L NO20073461 L NO 20073461L NO 20073461 A NO20073461 A NO 20073461A NO 20073461 A NO20073461 A NO 20073461A NO 20073461 L NO20073461 L NO 20073461L
Authority
NO
Norway
Prior art keywords
dissolution
salt
solution
basic drug
test
Prior art date
Application number
NO20073461A
Other languages
English (en)
Inventor
Yosuke Ueki
Satoshi Fujioka
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of NO20073461L publication Critical patent/NO20073461L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Matrikstypeformulering for forlenget frigjøring og en fremgangsmåte for fremstilling derav tilveiebringes, hvori oppløsningen med lav pH-avhengighet av et basisk medikament eller et salt derav ved et tidlig oppløsningsstadium kan sikres i en oppløsningstest, og hvori ettersom oppløsningstesten går fremover, vil et forhold mellom en oppløsningshastighet for det basiske medikamentet eller saltet derav i en sur testoppløsning og en oppløsningshastighet for det basiske medikamentet eller saltet derav i en nøytral testløsning (oppløsningshastighet i den sure testløsningen/oppløsningshastighet i den nøytrale testløsningen) reduseres med oppløsningstiden ved det sene oppløsningsstadiet, sammenlignet med det tidlige oppløsningsstadiet. Ifølge den foreliggende oppfinnelse inneholder matrikstypeformulering for forlenget frigjøring et basisk medikament eller et salt derav og i det minste én enterisk polymer, hvori løseligheten til det basiske medikamentet eller saltet derav i en 0,1 N hydrokloridsyreløsning og en nøytral vandig løsning, pH 6,0 er høyere enn i en basisk vandig løsning, pH 8,0.
NO20073461A 2004-12-27 2007-07-04 Matrikstypepreparater for vedvarende frigjoring som inneholder basiske medikamenter eller salter derav, samt fremgangsmate for fremstilling derav NO20073461L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2004376770 2004-12-27
JP2005110404 2005-04-06
US67548205P 2005-04-28 2005-04-28
JP2005132338 2005-04-28
PCT/JP2005/023853 WO2006070781A1 (ja) 2004-12-27 2005-12-27 塩基性薬物又はその塩を含有するマトリックス型徐放性製剤およびその製造方法

Publications (1)

Publication Number Publication Date
NO20073461L true NO20073461L (no) 2007-09-27

Family

ID=36614895

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073461A NO20073461L (no) 2004-12-27 2007-07-04 Matrikstypepreparater for vedvarende frigjoring som inneholder basiske medikamenter eller salter derav, samt fremgangsmate for fremstilling derav

Country Status (13)

Country Link
US (2) US20090208579A1 (no)
EP (1) EP1832298A4 (no)
JP (1) JP4999466B2 (no)
KR (1) KR100904602B1 (no)
CN (1) CN103550190A (no)
AU (1) AU2005320609B9 (no)
BR (1) BRPI0519407A2 (no)
CA (1) CA2592102C (no)
IL (1) IL183871A0 (no)
MX (1) MX2007007835A (no)
NO (1) NO20073461L (no)
NZ (1) NZ555901A (no)
WO (1) WO2006070781A1 (no)

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IL183871A0 (en) 2007-10-31
EP1832298A1 (en) 2007-09-12
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WO2006070781A1 (ja) 2006-07-06
AU2005320609A1 (en) 2006-07-06
CN103550190A (zh) 2014-02-05
CA2592102A1 (en) 2006-07-06
US20090208579A1 (en) 2009-08-20
EP1832298A4 (en) 2012-12-12
CA2592102C (en) 2012-01-24
JPWO2006070781A1 (ja) 2008-06-12
MX2007007835A (es) 2007-08-20
US20110045074A1 (en) 2011-02-24
AU2005320609B2 (en) 2009-07-02
KR20070089207A (ko) 2007-08-30
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NZ555901A (en) 2010-10-29
AU2005320609B9 (en) 2010-03-18

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